Astragalus Polysaccharide Hydrogels with Drug-Carrying Super Self-Assembly from Natural Herbs Promote Wound Healing DOI

Mingyuan Zhao,

Jiawei Xiang,

Yuan Meng

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: June 3, 2025

The regulation of the immune microenvironment is a key component wound healing, where suitable dressings with skin immunoreactivity can favorably affect process and promote repairing progress. Therefore, we developed an injectable photo-cross-linkable composite hydrogel─oxidized astragalus polysaccharide carboxymethyl chitosan/sodium methacrylated alginate magnesium ions hydrogel (OAPS-CMC/SAMA-Mg2+, OCS) loaded curcumin (Cur)-encapsulated Achyranthes bidentata supramolecular self-assemblies (NX SSA) (NX@Cur)─termed OCS/NX@Cur to synergistically accelerate repair. polysaccharide-dominated matrix provided superior anti-inflammatory ability. Meanwhile, NX@Cur strong angiogenesis accelerated collagen deposition. In cellular experiments rat model total defects, exhibited anti-inflammatory, antioxidant, angiogenic capabilities. These properties modulated inflammatory environment wound, thereby promoting formation granulation tissue neovascularization accelerating deposition re-epithelialization. conclusion, showed excellent repair capabilities, providing potential therapeutic option for combination super self-assembly natural hydrogels

Language: Английский

Unveiling Rheological Behavior of Hydrogels toward Magic 3D Printing Patterns DOI
Zhong‐Yong Yuan, Xiaowei Huang, Xinai Zhang

et al.

Food Hydrocolloids, Journal Year: 2025, Volume and Issue: unknown, P. 111505 - 111505

Published: May 1, 2025

Language: Английский

Citations

0
Astragalus Polysaccharide Hydrogels with Drug-Carrying Super Self-Assembly from Natural Herbs Promote Wound Healing DOI

Mingyuan Zhao,

Jiawei Xiang,

Yuan Meng

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: June 3, 2025

The regulation of the immune microenvironment is a key component wound healing, where suitable dressings with skin immunoreactivity can favorably affect process and promote repairing progress. Therefore, we developed an injectable photo-cross-linkable composite hydrogel─oxidized astragalus polysaccharide carboxymethyl chitosan/sodium methacrylated alginate magnesium ions hydrogel (OAPS-CMC/SAMA-Mg2+, OCS) loaded curcumin (Cur)-encapsulated Achyranthes bidentata supramolecular self-assemblies (NX SSA) (NX@Cur)─termed OCS/NX@Cur to synergistically accelerate repair. polysaccharide-dominated matrix provided superior anti-inflammatory ability. Meanwhile, NX@Cur strong angiogenesis accelerated collagen deposition. In cellular experiments rat model total defects, exhibited anti-inflammatory, antioxidant, angiogenic capabilities. These properties modulated inflammatory environment wound, thereby promoting formation granulation tissue neovascularization accelerating deposition re-epithelialization. conclusion, showed excellent repair capabilities, providing potential therapeutic option for combination super self-assembly natural hydrogels

Language: Английский

Citations

0