Multifunctional Micro/Nano-Textured Titanium with Bactericidal, Osteogenic, Angiogenic and Anti-inflammatory Properties: Insights from In Vitro and In Vivo Studies DOI Creative Commons
Théo Ziegelmeyer, Karolinne Martins de Sousa, Tzu‐Ying Liao

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101710 - 101710

Published: March 29, 2025

Titanium (Ti) is widely used as an implantable material for bone repair in orthopedics and dentistry. However, Ti implants are vulnerable to bacterial infections, which can compromise patient recovery lead implant failure. While a controlled inflammatory response promotes regeneration, chronic inflammation caused by infections Bone complex process inflammation, angiogenesis osteogenesis tightly interconnected, requiring cooperation between mesenchymal stem cells (MSC), macrophages endothelial cells. Here, we fabricated bio-inspired with either microstructured (Micro Ti) or nanostructured (Nano surface textures that exhibit robust mechano-bactericidal properties. In vitro, both textured surfaces improved blood coagulation osteogenic marker expression compared smooth surfaces. Additionally, Nano promoted macrophage polarization towards the M2 phenotype enhanced paracrine effects of MSCs on angiogenesis, key processes tissue regeneration. vivo kinetic analysis reconstruction rat calvarial model showed osseointegration, evidenced increased volume, mineral density, bone-implant contact. Notably, Micro no significant differences from control implants. These findings highlight potential nanopatterns simultaneously prevent enhance osseointegration modulating protein adsorption, osteogenesis. This study provides new insights into development bifunctional implants, offering perspectives next generation bone-related biomaterials.

Language: Английский

Engineering Multifunctional Surface Topography to Regulate Multiple Biological Responses DOI Creative Commons

Mohammad Asadi Tokmedash,

Changheon Kim,

Ajay P Chavda

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123136 - 123136

Published: Jan. 1, 2025

Language: Английский

Citations

4
Nanospiked Cellulose Gauze That Attracts Bacteria with Biomolecules for Reducing Bacterial Load in Burn Wounds DOI Creative Commons
Yuuki Hata, Hiromi Miyazaki, Shigeru Okamoto

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Nanostructuring surfaces is an emergent strategy to endow materials with abilities combat pathogenic bacteria. Nevertheless, it remains challenging create nanospike structures on the curved of polymer materials, including gauze and other microfibrous medical materials. Additionally, effects nanostructured bacteria in presence proteins vivo remain largely unexplored. Herein, we demonstrated decoration microfiber via self-assembly cello-oligosaccharides investigated nanospiked proteins. The had low bacterial adhesion properties absence proteins, whereas promoted adhesion. Analyses suggested that adsorbed protein layers nanospikes were involved Furthermore, adhesion-promoting exploited remove from burn wounds exudate containing using gauze.

Language: Английский

Citations

1
Multifunctional Micro/Nano-Textured Titanium with Bactericidal, Osteogenic, Angiogenic and Anti-inflammatory Properties: Insights from In Vitro and In Vivo Studies DOI Creative Commons
Théo Ziegelmeyer, Karolinne Martins de Sousa, Tzu‐Ying Liao

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101710 - 101710

Published: March 29, 2025

Titanium (Ti) is widely used as an implantable material for bone repair in orthopedics and dentistry. However, Ti implants are vulnerable to bacterial infections, which can compromise patient recovery lead implant failure. While a controlled inflammatory response promotes regeneration, chronic inflammation caused by infections Bone complex process inflammation, angiogenesis osteogenesis tightly interconnected, requiring cooperation between mesenchymal stem cells (MSC), macrophages endothelial cells. Here, we fabricated bio-inspired with either microstructured (Micro Ti) or nanostructured (Nano surface textures that exhibit robust mechano-bactericidal properties. In vitro, both textured surfaces improved blood coagulation osteogenic marker expression compared smooth surfaces. Additionally, Nano promoted macrophage polarization towards the M2 phenotype enhanced paracrine effects of MSCs on angiogenesis, key processes tissue regeneration. vivo kinetic analysis reconstruction rat calvarial model showed osseointegration, evidenced increased volume, mineral density, bone-implant contact. Notably, Micro no significant differences from control implants. These findings highlight potential nanopatterns simultaneously prevent enhance osseointegration modulating protein adsorption, osteogenesis. This study provides new insights into development bifunctional implants, offering perspectives next generation bone-related biomaterials.

Language: Английский

Citations

0