Self‐Doped and Biodegradable Glycosaminoglycan‐PEDOT Conductive Hydrogels Facilitate Electrical Pacing of iPSC‐Derived Cardiomyocytes

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Abstract Conductive polymers hold promise in biomedical applications owing to their distinct conductivity characteristics and unique properties. However, incorporating these into biomaterials poses challenges related mechanical performance, electrical stability, biodegradation. This study proposes an injectable hydrogel scaffold composed of a self‐doped conductive polymer, constituted sulfated glycosaminoglycan (GAG) with side chains PEDOT (poly 3,4‐ethylenedioxythiophene). brush copolymer is synthesized via oxidative polymerization from EDOT monomer grafted onto the backbone GAG. The GAG offers biodegradability, while sulfate groups act as acidic self‐doping agents. hydrogels form through oxime crosslinking, initially existing liquid mixture that undergoes gelation within tissue, allowing for injectability. show tunable stiffness kinetics influenced by both concentration pH, exhibit adhesive They showcase dual ionic electronic conductivity, where doping moieties, enhancing stability. These properties are associated facilitation pacing iPSC‐cardiomyocytes. Furthermore, biodegradation evidence biocompatibility, highlighting potential diverse applications.

Language: Английский

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Synthesis, characterization, and enhanced electrochemical behavior of polypyrrole doped ZrO2–ZnO electrode materials for supercapacitor applications

Frontiers in Energy Research, Journal Year: 2023, Volume and Issue: 11

Published: Aug. 10, 2023

The polypyrrole@ZrO 2 –ZnO (PPy@ZrO –ZnO) electrodes were synthesized using an in situ chemical oxidative method. samples characterized by XRD, FTIR, XPS, UV-vis, TGA, and BET. In addition, the electrochemical characteristics of are tested cyclic voltammetry (CV), galvanostatic charge discharge (G.C.D.), impedance spectroscopy (E.I.S.). values specific capacitances energy densities PPy@ZrO (1.0) (0.5) at a current density 0.5 A g −1 recorded as (395.3 F 508.5 Wh·kg ) (195.3 351.5 ), respectively. Furthermore, electrode stability for formed was also determined, which exhibited capacitance retention 90.2% 82.4% after cycling up to 4,000 cycles. This work provides efficient approach potential application supercapacitor.

Language: Английский

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Bioelectronic Applications of Intrinsically Conductive Polymers

Advanced Electronic Materials, Journal Year: 2023, Volume and Issue: 9(10)

Published: July 26, 2023

Abstract Since the discovery of conducting polyacetylene in 1970s, intrinsically polymers (ICPs) have attracted great attention because their interesting structure, properties, and applications. Notably different from conventional conductors such as metals doped semiconductors, ICPs high mechanical flexibility are light weight. In addition, properties can be easily tuned by controlling doping level, modifying chemical or forming composites with organic inorganic materials. Their application bioelectronics is particularly they good biocompatibility matching biological tissues. this article, methods to increase stretchability first reviewed often required for bioelectronic applications while pristine generally limited stretchability. The stretchable electrodes epidermal biopotential detection neural interfaces discussed. Then, employment sensing material sensors reviewed. They also important controllable drug delivery. Last, wearable energy harvesting storage devices including thermoelectric generators supercapacitors covered.

Language: Английский

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Biologicalisation in manufacturing – Current state and future trends

CIRP Annals, Journal Year: 2023, Volume and Issue: 72(2), P. 781 - 807

Published: Jan. 1, 2023

Language: Английский

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Recyclable, ultralow-hysteresis, multifunctional wearable sensors based on water-permeable, stretchable, and conductive cellulose/PEDOT:PSS hybrid films

Journal of Materials Chemistry A, Journal Year: 2024, Volume and Issue: 12(30), P. 19403 - 19413

Published: Jan. 1, 2024

This study presents a method to prepare stretchable, conductive, water-permeable, and recyclable hybrid films using hydroxyethyl cellulose PEDOT:PSS for eco-friendly sensors, with high sensitivity, low power consumption, hysteresis.

Language: Английский

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