Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 6, 2024
Abstract
Microporous
hydrogels
have
been
utilized
in
an
unprecedented
manner
the
last
few
decades,
combining
materials
science,
biology,
and
medicine.
Their
microporous
structure
makes
them
suitable
for
wide
applications,
especially
as
cell
carriers
tissue
engineering
regenerative
hydrogel
scaffolds
provide
spatial
platform
support
growth
proliferation,
which
can
promote
growth,
migration,
differentiation,
influencing
repair
regeneration.
This
review
gives
overview
of
recent
developments
fabrication
techniques
applications
hydrogels.
The
be
classified
into
two
distinct
categories:
non‐injectable
including
freeze‐drying
method,
two‐phase
sacrificial
strategy,
3D
biofabrication
technology,
etc.,
injectable
mainly
microgel
assembly.
Then,
biomedical
engineering,
but
not
limited
to
bone
regeneration,
nerve
vascular
muscle
regeneration
are
emphasized.
Additionally,
ongoing
foreseeable
current
limitations
illustrated.
Through
stimulating
innovative
ideas,
present
paves
new
avenues
expanding
application
engineering.
Droplets,
tiny
liquid
compartments,
are
increasingly
emerging
in
the
biomedical
and
biomanufacturing
fields
due
to
their
unique
properties
serve
as
templates
or
independent
reaction
units.
Currently,
straightforward
efficient
generation
of
various
functional
droplets
a
biofriendly
manner
remains
challenging.
Herein,
novel
microfluidic-assisted
pneumatic
strategy
is
described
for
customizable
high-throughput
production
monodispersed
droplets,
droplet
size
can
be
precisely
controlled
via
simplified
gas
pressure
regulation
module.
In
particular,
numerous
uniform
alginate
microcarriers
rapidly
fabricated
an
all-aqueous
manner,
wherein
encapsulated
islet
liver
cells
exhibit
favorable
viability
biological
functions.
Furthermore,
by
changing
microchannel
configuration,
several
fluid
manipulation
functions
developed
microfluidic
technology,
such
mixing
laminar
flow,
successfully
incorporated
into
this
platform.
The
generators
with
scalable
functionality
demonstrated
many
scenarios,
including
on-demand
distribution
cell-mimetic
particles,
continuous
synthesis
metal-organic
framework
(MOF),
controllable
preparation
compartmental
microgel,
etc.
These
may
provide
sustainable
inspiration
developing
applications
tissue
organ
engineering,
biomaterials
design,
bioprinting
nozzles,
other
fields.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 6, 2024
Abstract
Microporous
hydrogels
have
been
utilized
in
an
unprecedented
manner
the
last
few
decades,
combining
materials
science,
biology,
and
medicine.
Their
microporous
structure
makes
them
suitable
for
wide
applications,
especially
as
cell
carriers
tissue
engineering
regenerative
hydrogel
scaffolds
provide
spatial
platform
support
growth
proliferation,
which
can
promote
growth,
migration,
differentiation,
influencing
repair
regeneration.
This
review
gives
overview
of
recent
developments
fabrication
techniques
applications
hydrogels.
The
be
classified
into
two
distinct
categories:
non‐injectable
including
freeze‐drying
method,
two‐phase
sacrificial
strategy,
3D
biofabrication
technology,
etc.,
injectable
mainly
microgel
assembly.
Then,
biomedical
engineering,
but
not
limited
to
bone
regeneration,
nerve
vascular
muscle
regeneration
are
emphasized.
Additionally,
ongoing
foreseeable
current
limitations
illustrated.
Through
stimulating
innovative
ideas,
present
paves
new
avenues
expanding
application
engineering.
