ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(28), P. 36117 - 36130

Published: July 1, 2024

Better infection control will accelerate wound healing and alleviate associated healthcare burdens. Traditional antibacterial dressings often inadequately infections, inadvertently promoting resistance. Our research unveils a novel, dual-functional living dressing that autonomously generates agents delivers electrical stimulation, harnessing the power of spore-forming Bacillus subtilis. This is built on an innovative wearable microbial fuel cell (MFC) framework, using B. subtilis endospores as powerful, dormant biocatalyst. The are resilient, reactivating in nutrient-rich exudate to produce electricity compounds. combination allows outcompete pathogens for food other resources, thus fighting infections. strategy enhanced by extracellular synthesis tin oxide copper nanoparticles endospore surface, boosting action, stimulation. Moreover, MFC framework introduces pioneering design featuring conductive hydrogel embedded within paper-based substrate. arrangement ensures stability sustains healing-friendly moist environment. approach has proven very effective against three key biofilms: Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus demonstrating exceptional capabilities both vitro ex vivo models. innovation marks significant leap forward MFC-based care, offering potent solution treating infected wounds.

Language: Английский