Hydrogen Peroxide Fuel Cells and Self-Powered Electrochemical Sensors Based on the Principle of a Fuel Cell with Biomimetic and Nanozyme Catalysts

Biosensors, Journal Year: 2025, Volume and Issue: 15(2), P. 124 - 124

Published: Feb. 19, 2025

The operating principle of a fuel cell is attracting increasing attention in the development self-powered electrochemical sensors (SPESs). In this type sensor, chemical energy analyzed substance converted into electrical galvanic through spontaneous reactions, directly generating an analytical signal. Unlike conventional (amperometric, voltammetric, and impedimetric) sensors, no external form applied potential required for redox detection reactions to occur. SPESs therefore have several important advantages over sensors. They do not require power supply modulation system, which saves costs. devices also offer greater simplicity are more compatible applications wearable sensor as well vivo situ use. Due dual properties hydrogen peroxide, it possible develop membraneless cells fuel-cell-based peroxide SPESs, sample used only source energy, both oxidant reductant (fuel). This suppresses dependence on availability oxygen. Electrode catalyst materials different reaction pathways at cathode anode one-compartment key technology implementation characteristics SPESs. article provides overview designs H2O2-H2O2 H2O2 focusing biomimetic nanozyme catalysts, highlights recent innovations prospects hydrogen-peroxide-based (bio)electrochemical analysis.

Language: Английский

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Recent Progress of Polymer-Based Biosensors for Cancer Diagnostic Applications: Natural versus Synthetic Polymers

ACS Omega, Journal Year: 2025, Volume and Issue: 10(9), P. 8816 - 8831

Published: March 3, 2025

Early diagnosis of cancer can significantly contribute to improving therapeutic outcomes and enhancing survival rates for patients. Polymer-based biosensors have emerged as a promising tool detection due their high sensitivity, selectivity, low cost. These utilize functionalized polymers in different parts the body detect biomarkers biological samples. This approach offers several advantages over traditional methods, including real-time monitoring noninvasive while maintaining sensitivity accuracy. review discusses recent advances development polymer-based design, fabrication, performance. The essential characteristics biosensing devices are presented, along with examples natural synthetic commonly utilized biosensors. Furthermore, strategies employed tailor improve applications future perspectives application also highlighted. Integrating these advancements will illuminate potential transformative tools early management cancer.

Language: Английский

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High-Performance Biosensing Platforms Based on Enzyme-Linked Nucleic Acid Amplification Regulated by Synergistic Allosteric Hairpin Catalysis of Bimetallic Nanozymes and Its Mechanisms

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Sugar cane smut disease can greatly decrease both the production and quality of sugar cane, its early diagnosis is an effective strategy to ensure increase income cane. Therefore, developing high-precision detection methods has major implications for actual Herein, we synthesize bimetallic nanozymes Fe3O4@AuNPs with excellent glucose oxidase-like activity nitrogen-doped graphdiyne (N-GDY) conductivity interfacial loading capacity, which are used as catalysts biofuel cells flexible electrode substrates, respectively. An allosteric hairpin-regulated enzymatic cascade nucleic acid amplification employed construct a novel biosensing platform precise highly sensitive analysis pathogen causing disease, catalytic mechanism studied. The specifically cause complementary region hairpin migrate form new functional hairpin. Under promotion enzymes, dual occurs using template outputs large amount double-stranded products, captured by RCA long chain on biocathode. At cathode, DNA double strands capable holding quantity Ru[(NH3)6]3+ through electrostatic attraction. anode catalyze oxidation produce electrons, AuNPs/N-GDY efficiently transfer electrons cathode obtain strong open-circuit voltage signal, exhibits linear correlation in range 0.0001-10000 pM, limit 53.29 aM (S/N = 3). sensing offers reliable method that allows accurate great application development potential identification on-site rapid detection.

Language: Английский

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Polycrystalline boron nitride microflowers for non-invasive vitamin B3 (nicotinamide) sensing

Diamond and Related Materials, Journal Year: 2025, Volume and Issue: unknown, P. 112296 - 112296

Published: April 1, 2025

Language: Английский

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Innovations in graphene-based electrochemical biosensors in healthcare applications

Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(5)

Published: April 9, 2025

Abstract The isolation of a single atomic layer graphite, known as graphene, marked fundamental moment that transformed the field materials science. Graphene-based nanomaterials are recognized for their superior biocompatibility compared with many other types nanomaterials. Moreover, one main reasons growing interest in graphene is its potential applications emerging technologies. Its key characteristics, including high electrical conductivity, excellent intrinsic charge carrier mobility, optical transparency, substantial specific surface area, and remarkable mechanical flexibility, position it an ideal candidate solar cells touch screens. durability further establishes strong contender developing robust materials. To date, variety methods, such traditional spectroscopic techniques chromatographic approaches, have been developed detecting biomolecules, drugs, heavy metals. Electrochemical portability, selectivity, impressive sensitivity, offer considerable convenience both patients professionals point-of-care diagnostics. Recent advancements significantly improved capacity rapid accurate detection analytes trace amounts, providing benefits biosensor technology. Additionally, integration nanotechnology has markedly enhanced sensitivity selectivity electrochemical sensors, yielding results. Innovations point-of-care, lab-on-a-chip, implantable devices, wearable sensors discussed this review. Graphical abstract

Language: Английский

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Hybrid Poly(Methacrylic Acid‐Co‐Acrylamide)‐Polythiophene Nanofibers for Salivary Diagnosis of Oral Squamous Cell Carcinoma

Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Abstract Oral squamous cell carcinoma (OSCC) is a major health concern in high‐risk regions globally, with rising mortality rates indicating the urgent need for early detection tools. This study presents an innovative point‐of‐care (POC) diagnostic tool using disposable microelectrodes to detect cholic acid, crucial OSCC biomarker, human saliva. By combining poly(methacrylic acid‐co‐acrylamide) copolymer (CoP) polythiophene (PTh) nanofibers as selective coatings disposable, screen‐printed carbon electrodes (SPCE), developed CoP‐PTh/SPCE sensors demonstrate exceptional performance. Using impedance spectroscopy and voltammetric techniques, electrochemical oxidation of acid solution saliva samples investigated. The exhibit outstanding sensitivity 1.05 µA cm −2 n m −1 (74.2 µ ), limit (LOD) 0.240 , quantification (LOQ) 0.727 demonstrating their superior capabilities. Additionally, these remarkable selectivity against structurally similar compounds such cholesterol various salivary analytes. practical application realized through 97.67±1.08% recovery spiked concentrations samples. highlights potential reliable, efficient, non‐invasive POC testing, offering promising diagnosis poorly differentiated OSCC.

Language: Английский

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Recent Advances in Bioactive Materials: Future Perspectives and Opportunities in Oral Cancer Biosensing

Talanta, Journal Year: 2024, Volume and Issue: unknown, P. 127494 - 127494

Published: Dec. 1, 2024

Language: Английский

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