Prospects for the use of nanozyme-based electrochemical and colorimetric sensors for antibiotic detection

Talanta, Journal Year: 2025, Volume and Issue: 286, P. 127524 - 127524

Published: Jan. 7, 2025

Language: Английский

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Two-dimensional nanomaterials-based optical biosensors empowered by machine learning for intelligent diagnosis

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118162 - 118162

Published: Feb. 1, 2025

Language: Английский

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3D multilayered sheet-like nanozyme enables the multiplex, flexible, and ultrasensitive detection of small-molecule drugs by immunochromatographic assay

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 158162 - 158162

Published: Nov. 1, 2024

Language: Английский

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Immunochromatographic food control tools: New developments and practical prospects

Theory and practice of meat processing, Journal Year: 2025, Volume and Issue: 9(4), P. 280 - 295

Published: Jan. 20, 2025

In the modern food production technologies, tools and means of simple rapid testing raw materials, intermediate products final ready-to-consume are in high demand. This monitoring allows determining content toxic pathogenic contaminants confirms compliance objects being tested with established regulatory requirements. Mobile tests (so called test systems) provide opportunity wide range without involving specialized laboratories highly qualified specialists. Thus, systems for detection serve as useful addition to confirming instrumental analytical methods. An actively developing approach this field is using immunochromatographic strips, which strips all necessary reagents applied membrane components system. Contact strip sample tested, initiates further interactions generates recordable or visually assessable optical signal. The market based on analysis constantly growing, thus offering permanently widening choice solutions. However, recent years there has been a real boom new developments immunochromatography field, various options sensitive information capacitive systems. study systematizes these provides their comparative assessment terms prospects technological implementation practical application coming years. opportunities designing antibodies alternative receptor molecules controlling affinity selectivity recognition compounds monitored considered. advantages limitations nanodispersed markers non-optical methods registration discussed. quantitative via characterized. developed design multiplex control — simultaneous several presented. Examples integration automatic registration, processing, transfer, storage results numerous represented.

Language: Английский

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From Traditional to Modern: Nanotechnology-Driven Innovation in Mycotoxin Sensing for Chinese Herbal Medicines

Talanta, Journal Year: 2025, Volume and Issue: 288, P. 127681 - 127681

Published: Feb. 2, 2025

Language: Английский

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Enhancing the Peroxidase-Mimicking Activity of Gold Nanoparticles for Lateral Flow Assays: Quantitative Evaluation in a Kinetic View

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Highly sensitive lateral flow immunoassays (LFIAs) are essential for various point-of-care applications, and gold nanoparticles (Au NPs) by far the most commonly used labels. However, conventional LFIAs often suffer from high detection limits (LOD) or low sensitivity. In this study, we investigated three strategies to enhance sensitivity of improving peroxidase-mimicking (POD) activity Au NPs. The POD unmodified NPs was negligible (<0.01 units/mg, U/mg). first strategy involved coupling with horseradish peroxidase (HRP), which increased 65 U/mg. second approach forming a thin palladium iridium shell on NPs, elevated 0.69-0.71 third binding mercury ions (Hg2+) resulting in up 3 Finally, developed simple quantitative model estimate LOD based kinetic parameters. Using Au-HRP conjugates, demonstrated that experimentally measured consistent calculated values. provides framework evaluating catalytic signal amplification can be guide development highly assays.

Language: Английский

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Bioinspired Cerium Nanozyme Microenvironment Regulation for Efficient Dephosphorylation and Detection of Organophosphorus Pesticides

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Abstract Mimicking the structure of natural enzyme active sites offers a promising strategy for rational design nanozymes. However, this biomimetic approach predominantly focuses on replicating configuration metal center in enzymes, often overlooking critical influence catalytic site's microenvironment. Here, inspired by and coordination microenvironment organophosphorus hydrolase (OPH), Ce 2 O CN /NC, novel cerium‐based nanozyme is first reported to mimic OPH. In species serve as sites, while adjacent N site ([N═C═N] 2− ) functions general base, mimicking histidine enzymes facilitate hydrolysis process. Using paraoxon model target, /NC demonstrates rapid dephosphorylation phosphotriester across wide range temperatures pH values, significantly outperforming OPH CeO nanoparticles. The systematic experiments theoretical calculations reveal underlying mechanisms responsible enhanced OPH‐mimicking performance. Capitalizing its phosphatase‐like activity, successfully employed develop colorimetric biosensor selective detection pesticides. This study holds great promise developing efficient nanozymes broadens Ce‐based

Language: Английский

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Biomimetically Engineering Valency in Copper Aerogel Toward Efficient Laccase‐Mimicking Nanozyme

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract Developing nanozymes with high intrinsic activity to bridge the gap natural enzymes has received unremitting attention. In this study, inspired by copper active center for laccase and multivalent characteristic of Cu, valence state Cu‐based aerogel is modulated via adjusting reductant usage mimicking laccase. The laccase‐mimicking well‐tailored manipulation, theoretical calculations unveil mechanism that Cu 0 I species enhance substrate adsorption capability II are paramount lowering activation barrier synergistically. Heterogeneous metals further incorporated promote valency‐conversion biomimetic electron transfer, conferring constructed CuPt 7.5% nanozyme an ultralow detectable limit 1 n m phenolic pollutants. This work highlights multivalence on provides insights into underlying catalytic mechanism, shedding light rational design high‐performance practical application.

Language: Английский

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A Critical Review of Sensors for Detecting Per- and Polyfluoroalkyl Substances: Focusing on Diverse Molecular Probes

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121669 - 121669

Published: April 1, 2025

Language: Английский

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Research Progress on the Application of Nanoenzyme Electrochemical Sensors for Detecting Zearalenone in Food

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(10), P. 712 - 712

Published: May 9, 2025

Zearalenone (ZEN) is a common mycotoxin widely found in food crops such as corn. The toxicity of ZEN manifested multiple hazards to reproduction, genes, cells, and immune systems. Long-term exposure may have serious impact on health, so it has received extensive attention due its potential harm human animal health. In order ensure safety, countries formulated corresponding content limit standards promoted the development efficient rapid detection technologies. This paper reviews research progress based nanoenzyme electrochemical sensors. Firstly, basic situation was introduced, including physical chemical properties, toxicity, related regulations standards. Secondly, advantages disadvantages traditional methods new technologies are analyzed, application sensors discussed, especially aptamer sensors, immune-electrochemical this paper, discussed detail, terms sensitivity, selectivity, detection. However, still face some challenges practical applications, high production costs, control signal amplification effects, safety issues nanomaterials. Finally, looks forward future direction proposes possible solutions further improve their stability, reduce optimize sensing performance.

Language: Английский

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