Synthetic Routes to 2-Iminothiazolidines: State-of-the-Art 2006-2020

Current Organic Chemistry, Journal Year: 2020, Volume and Issue: 24(24), P. 2823 - 2844

Published: Oct. 20, 2020

Multiheteroatom-containing small-sized cyclic molecules such as 2- iminothiazolidines are often found to possess beneficial pharmacological properties. In this review article, the biological significance of 2-iminothiazolidines is discussed and literature reports published in last 15 years spanning from 2006 2020 describing various preparative routes access 2-iminothiazolidine derivatives have been categorically chronologically described. The notable synthetic methods here involve ringexpansion transformations nonactivated activated aziridines, thiiranes, epoxides, other miscellaneous reactions.

Language: Английский

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Three-Membered Ring Systems

Progress in heterocyclic chemistry, Journal Year: 2016, Volume and Issue: unknown, P. 57 - 94

Published: Jan. 1, 2016

Language: Английский

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Merging Ring-Opening 1,2-Metallate Shift with Asymmetric C(sp³)–H Borylation of Aziridines

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(28), P. 18879 - 18885

Published: July 5, 2024

Chiral secondary alkyl amines with a vicinal quaternary stereocenter are undoubtedly important and ubiquitous subunits in natural products pharmaceuticals. However, their asymmetric synthesis remains formidable challenge. Herein, we merge the ring-opening 1,2-metallate shift iridium-catalyzed enantioselective C(

Language: Английский

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Asymmetric Ring Opening of Aziridines Using a Chiral Magnesium Complex

Synfacts, Journal Year: 2017, Volume and Issue: 13(11), P. 1168 - 1168

Published: Oct. 19, 2017

Key words aziridines - asymmetric ring opening pyrazoles desymmetrization

Language: Английский

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