Handbook of CH‐Functionalization,
Journal Year:
2022,
Volume and Issue:
unknown, P. 1 - 18
Published: Oct. 1, 2022
Abstract
This
article
summarizes
the
design
of
catalytic
systems
and
regioselective
CH
borylation
(hetero)aromatic
compounds
using
noncovalent
interactions,
such
as
hydrogen
bonding
Lewis
acid–base
interaction,
between
substrate
recognition
part
ligand
catalysts
functional
group
substrates.
Formal
meta‐selective
introduction
a
variety
groups
into
based
on
is
explained.
In
addition,
acceleration
reaction
expression
specificities
are
introduced.
summary
section,
recently
reported
reactions
interaction
method
several
reviews
accounts
cited.
Synthesis,
Journal Year:
2022,
Volume and Issue:
55(07), P. 1123 - 1129
Published: Nov. 21, 2022
Abstract
A
novel
C–H
functionalization
method
was
successfully
explored
by
a
reductive
three
molecule
coupling
of
benzaldehydes
and
esters
mediated
samarium
cuprous
iodide;
thus,
the
diarylmethanol
skeletons
were
afforded
readily
via
an
in
situ
esterification
one-pot.
Substrates
including
variety
different
investigated,
desired
products
obtained
moderate
to
good
yields
under
mild
conditions.
European Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
2021(25), P. 3598 - 3603
Published: June 15, 2021
Abstract
A
novel
design‐based
removable
N
,
O
‐bidentate
directing
group
based
on
cheap
and
commercially
available
4‐aminoantipyrine
(
AAP
)
is
reported.
Aromatic
AP
amides
bearing
underwent
efficient
Ru‐catalyzed
C(sp
2
)−H
arylation
using
[RuCl
(PPh
3
]
as
a
catalyst
aryl
bromides
electrophiles.
The
bidentate
enabled
the
C−H
functionalization
reaction
with
good
scope,
functional
tolerance
in
decent
yields.
Angewandte Chemie,
Journal Year:
2023,
Volume and Issue:
135(45)
Published: June 7, 2023
Abstract
Die
C−H‐Aktivierung
ist
eine
attraktive
Methode
zur
Steigerung
der
molekularen
Komplexität,
ohne
Vorfunktionalisierung
des
Substrats.
Im
Gegensatz
zu
den
etablierten
Kreuzkupplungsmethoden
die
in
großem
Maßstab
weniger
erforscht
und
ihre
Anwendung
bei
Herstellung
von
Arzneimitteln
mit
erheblichen
Hürden
verbunden.
inhärenten
Vorteile,
wie
kürzere
Synthesewege
einfachere
Ausgangsmaterialien,
motivieren
Medizinal‐
Prozesschemiker
jedoch
dazu,
diese
Herausforderungen
überwinden
C−H‐Aktivierungsschritte
für
Synthese
pharmazeutisch
relevanter
Verbindungen
nutzen.
In
diesem
Aufsatz
werden
wir
Beispiele
Arzneimitteln/Wirkstoffkandidaten
behandeln,
denen
einem
präparativen
Synthesemaßstab
(zwischen
355
mg
130
kg)
durchgeführt
wurden.
Optimierungsprozesse
beschrieben
jedes
Beispiel
wird
im
Hinblick
auf
seine
Vor‐
Nachteile
untersucht,
um
dem
Leser
ein
umfassendes
Verständnis
Potenzials
C−H‐Aktivierungsmethoden
vermitteln.
Handbook of CH‐Functionalization,
Journal Year:
2022,
Volume and Issue:
unknown, P. 1 - 109
Published: Sept. 28, 2022
Abstract
Related
to
ortho
‐CH
functionalization
of
arenes
by
proximal
σ‐chelation,
palladium‐catalyzed
distal
meta
‐
or
para
arene
substrates
remains
significant
challenges
owing
the
unstable
macrocyclic
transition
state.
Through
utilizing
deliberated
directing
templates
Pd/norbornene
relay
strategy,
on
phenyl
ring
could
be
efficiently
functionalized
in
presence
Pd
catalyst.
This
article
summarizes
recent
progress
about
Pd‐catalyzed
remote
and
diverse
derivatives.
Handbook of CH‐Functionalization,
Journal Year:
2022,
Volume and Issue:
unknown, P. 1 - 18
Published: Oct. 1, 2022
Abstract
This
article
summarizes
the
design
of
catalytic
systems
and
regioselective
CH
borylation
(hetero)aromatic
compounds
using
noncovalent
interactions,
such
as
hydrogen
bonding
Lewis
acid–base
interaction,
between
substrate
recognition
part
ligand
catalysts
functional
group
substrates.
Formal
meta‐selective
introduction
a
variety
groups
into
based
on
is
explained.
In
addition,
acceleration
reaction
expression
specificities
are
introduced.
summary
section,
recently
reported
reactions
interaction
method
several
reviews
accounts
cited.
