Chinese Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
43(9), P. 3006 - 3006
Published: Jan. 1, 2023
As
one
of
the
most
important
structural
motifs
in
natural
compounds
and
active
pharmaceutical
ingredients,
azaspiro[4.5]trienonesderivatives
have
been
widely
used
field
organic
synthesis
due
to
their
excellent
properties
biological
activities.In
recent
years,
several
methods,
such
as
transition
metal
involvement,
visible
light
promotion,
metal-free
involvement
electrochemical
efficiently
construct
various
functional
groups
azaspiro[4.5]trienones.The
advances
azaspiro[4.5]trienones
are
reviewed,
representative
substrates
reaction
mechanisms
summarized
discussed.
Organic & Biomolecular Chemistry,
Journal Year:
2022,
Volume and Issue:
20(18), P. 3767 - 3778
Published: Jan. 1, 2022
Nitrogen
heterocycles,
especially
polycyclic
compounds,
are
significant
skeletons
in
valuable
molecules.
Herein,
we
developed
an
efficient
and
practical
visible-light-induced
acylation/cyclization
of
active
alkenes
with
acyl
oxime
derivatives
for
constructing
acylated
indolo/benzimidazo-[2,1,a]isoquinolin-6(5H)
ones.
This
reaction
was
compatible
various
functional
groups
a
series
fused
indole/imidazole
were
prepared
up
to
95%
yield
at
room
temperature.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(6), P. 2667 - 2667
Published: March 15, 2023
The
synthetic
strategies
of
oxime
derivatives
participating
in
radical-type
reactions
have
been
rapidly
developed
the
last
few
decades.
Among
them,
N–O
bond
cleavage
esters
leading
to
formation
nitrogen-centered
radicals
triggers
adjacent
C–C
produce
carbon-centered
free
radicals,
which
has
virtually
used
organic
synthesis
recent
years.
Herein,
we
summarized
radical
involving
and
through
this
special
reaction
form,
including
those
from
acyl
ester
cyclic
ketoxime
derivatives.
These
contents
were
systematically
classified
according
different
types.
In
review,
after
2021
included,
with
emphasis
on
substrate
scope
mechanism.
ChemCatChem,
Journal Year:
2023,
Volume and Issue:
15(13)
Published: May 11, 2023
Abstract
The
light‐promoted
regioselective
germylation
of
aryl
propiolamides/alkynoates
with
germanium
hydrides
is
reported.
germyl‐containing
spiro[4.5]trienones
were
obtained
when
N
‐arylpropiolamides
used
via
sequential
C−Ge
and
C−C
bond
formation,
while
alkynoates
delivered
the
vinylgermanes
radical
Smiles
rearrangement
CO
2
release.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(23), P. 5843 - 5850
Published: Jan. 1, 2023
A
chromium-catalyzed
reductive
allylic
defluorinative
acylation
of
trifluoromethyl-substituted
alkenes
with
acyl
oxime
esters
has
been
developed,
allowing
for
efficient
synthesis
various
ketones
bearing
a
gem
-difluoroalkene
unit.
Organic & Biomolecular Chemistry,
Journal Year:
2021,
Volume and Issue:
19(41), P. 9012 - 9020
Published: Jan. 1, 2021
A
nitrogen-centered
radical-mediated
carbon–carbon
bond
cleavage
strategy
for
the
construction
of
3-acylcoumarins
via
visible-light-induced
cascade
acylation/cyclization
alkynoates
with
acyl
oxime
compounds
is
reported.
New Journal of Chemistry,
Journal Year:
2022,
Volume and Issue:
46(9), P. 4470 - 4482
Published: Jan. 1, 2022
A
visible-light-catalyzed
difluoroacetylated
spirocyclization
of
N
-arylpropiolamides
with
ethyl
bromodifluoroacetate
as
a
CF
2
CO
Et
radical
precursor
is
described
using
fac
-[Ir(ppy)
3
]
photocatalyst.
Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
366(3), P. 488 - 493
Published: Dec. 23, 2023
Abstract
A
four‐component
reaction
of
N
‐arylpropiolamides,
Hantzsch
esters,
Na
2
S
O
5
and
water
via
a
radical
cascade
cyclization
process
with
the
insertion
sulfur
dioxide
mediated
by
K
8
is
reported.
series
alkylsulfonated
spiro[4,5]
trienones
are
prepared
up
to
86%
yield
good
functional
group
tolerance
substrate
applicability.
Preliminary
mechanism
experiments
indicate
that
carbonyl
oxygen
originated
from
water.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(29), P. 5924 - 5929
Published: Jan. 1, 2024
A
transition-metal-
and
photocatalyst-free
photochemical
acylation
strategy
driven
by
the
photoexcitation
of
an
electron
donor–acceptor
(EDA)
complex
has
been
developed.
ChemCatChem,
Journal Year:
2024,
Volume and Issue:
16(20)
Published: June 27, 2024
Abstract
Herein,
a
method
for
the
assembly
of
biologically
valuable
3‐selenospiro[4,5]decatrienones
through
CuBr
2
‐catalyzed
ispo
‐cyclization
Se
powder,
boronic
acids,
and
N
‐(
p
‐methoxyaryl)propiolamides
has
been
established.
In
this
protocol,
noble
transition
metal,
prefunctionalized
selenylation
reagent,
strong
chemical
oxidant
are
not
employed.
This
feature
wide
substrate
scope,
good
functional
group
tolerance,
easy
operation,
employing
earth‐abundant
metal
as
catalyst
green
air
oxidant.
Furthermore,
several
derivatizations
performed
to
showcase
practicability
our
strategy.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(37), P. 7628 - 7631
Published: Jan. 1, 2024
A
visible-light-mediated
radical
cascade
cyclization
of
N
-(
o
-cyanobiaryl)acrylamides
with
oxime
esters
for
the
assembly
acyl-containing
pyrido[4,3,2-
gh
]phenanthridines
has
been
developed.
