Biomedicine and Chemical Sciences,
Journal Year:
2022,
Volume and Issue:
1(4), P. 234 - 240
Published: Oct. 1, 2022
In
this
short
review
definition,
mechanism,
and
recent
developments
of
the
Stetter
reaction,
in
period
last
ten
years
from
2011
to
2021
are
presented.
This
reaction
comprises
N-heterocyclic
carbene
(NHC)-catalyzed
umpolung
aldehydes
followed
by
their
capturing
with
activated
carbon-carbon
double
bonds
(Michael
acceptors).
work
includes
also
progresses
inter-molecular
intra-molecular
versions
enantioselective
transformations.
Underscoring
advances
applications
synthesis
various
heterocyclic
systems
total
natural
products
have
been
introduced.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(49)
Published: Aug. 22, 2023
Abstract
Much
progress
has
been
made
in
the
development
of
methods
to
both
create
compounds
that
contain
C−F
bonds
and
functionalize
bonds.
As
such,
are
becoming
common
versatile
synthetic
functional
handles.
This
review
summarizes
advantages
defluorinative
functionalization
reactions
for
small
molecule
synthesis.
The
coverage
is
organized
by
type
carbon
framework
fluorine
attached
mono‐
polyfluorinated
motifs.
main
challenges,
opportunities
advances
discussed
each
class
organofluorine.
Most
text
focuses
on
case
studies
illustrate
how
defluorofunctionalization
can
improve
routes
targets
or
properties
enable
unique
mechanisms
reactions.
broader
goal
showcase
incorporating
exploiting
design
routes,
improvement
specific
advent
new
methods.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(31), P. 6246 - 6276
Published: Jan. 1, 2024
Recent
advances
in
the
preparation
of
trifluoromethyl-containing
heterocyclics
via
trifluoromethyl
building
block
strategies
over
period
from
2019
to
present
are
systematically
summarized
and
discussed.
Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(33), P. 4872 - 4890
Published: Jan. 1, 2023
Recent
advances
in
the
direct
synthesis
of
trifluoromethyl-containing
heterocycles
from
trifluoroacetimidoyl
chlorides
(TFAICs)
and
derivatives,
including
trifluoroacetimidohydrazides
(TFAIHs)
CF3-imidoyl
sulfoxonium
ylides
(TFISYs),
are
systematically
summarized
discussed.
The
cascade
annulation
reactions
synthons
with
suitable
coupling
partners
have
emerged
as
a
powerful
promising
tool
for
construction
variety
trifluoromethyl-substituted
heterocycles.
Compared
other
building
blocks,
TFAICs
derivatives
notable
merits
easy
availability
handling,
relative
stability
safety,
high
reactivity.
Organic Chemistry Frontiers,
Journal Year:
2022,
Volume and Issue:
9(15), P. 4192 - 4208
Published: Jan. 1, 2022
In
this
review,
we
summarize
the
state-of-the-art
advances
in
difluoromethylation
of
heterocycles
via
a
radical
process
over
past
few
years
(2018
to
early
2022).
Organic & Biomolecular Chemistry,
Journal Year:
2022,
Volume and Issue:
20(27), P. 5365 - 5376
Published: Jan. 1, 2022
The
selective
functionalization
of
inert
C–F
bonds
in
trifluoromethylated
carbonyl
compounds
has
been
summarized
and
the
reaction
mechanisms
are
also
discussed.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(9), P. 1819 - 1823
Published: Feb. 28, 2024
Ring
expansion
of
strained
small
rings
provides
an
efficient
method
for
the
synthesis
various
high-value
carbocycles
and
heterocycles.
Here
we
report
BF3·Et2O
as
both
activating
reagent
fluorine
source,
enabling
ring
phosphirane
P–F
bond
formation.
Treatment
1-iminylphosphirane
complexes
with
resulted
in
1,2-azaphospholidines,
while
reaction
1-acylphosphirane
afforded
1,2-dihydrophosphetes.
The
path
was
tuned
by
nucleophilicity
N
O
atoms
toward
intermediate
phosphenium
cation.
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(7), P. 7128 - 7134
Published: Feb. 8, 2023
Amide
compounds
are
important
organic
compounds,
which
play
an
role
in
biomedical
chemistry,
materials
science,
life
and
other
fields.
The
synthesis
of
α-CF3
amides,
especially
containing
3-(trifluoromethyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepine-2-one,
has
long
been
a
challenge
due
to
the
tensile
properties
instability
rings.
Here,
we
report
example
palladium-catalyzed
carbonylation
CF3-containing
olefin
form
acrylamide.
By
controlling
ligands,
can
get
different
amide
as
products.
This
method
good
substrate
adaptability
functional
group
tolerance.
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(10), P. 3524 - 3529
Published: Jan. 1, 2024
A
visible-light-promoted
gold-catalyzed
fluoroarylation
of
gem
-difluoroallenes
is
developed.
This
reaction
proceeds
in
a
highly
stereo-
and
regioselective
manner
enables
facile
construction
tri-
tetra-substituted
trifluoromethyl
alkenes.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(6), P. 1191 - 1191
Published: March 7, 2024
Incorporation
of
a
trifluoromethyl
group
with
1,2,3-triazoles
motifs
was
described.
We
explored
click
reaction
approach
for
regioselective
synthesis
1-susbstituted-4-trifluoromethyl-1,2,3-triazoles
in
which
1,8-diazabicyclo[5.4.0]undec-7-ene
(DBU)
reacts
commercial
2-bromo-3,3,3-trifluoropropene
(BTP)
to
form
3,3,3-trifloropropyne
(TFP)
situ.
Arising
from
merits
associated
the
availability
and
stability
BTP,
high
efficiencies
CuI/1,10-Phenanthroline
(Phen)-catalyzed
cycloaddition
reactions
azides
alkynes,
this
readily
performed
process
takes
place
target
yields,
wide
azide
substrate
scope.
The
potential
value
protocol
demonstrated
by
its
application
gram-scale
reaction.
