Biomedicine and Chemical Sciences,
Journal Year:
2022,
Volume and Issue:
1(4), P. 234 - 240
Published: Oct. 1, 2022
In
this
short
review
definition,
mechanism,
and
recent
developments
of
the
Stetter
reaction,
in
period
last
ten
years
from
2011
to
2021
are
presented.
This
reaction
comprises
N-heterocyclic
carbene
(NHC)-catalyzed
umpolung
aldehydes
followed
by
their
capturing
with
activated
carbon-carbon
double
bonds
(Michael
acceptors).
work
includes
also
progresses
inter-molecular
intra-molecular
versions
enantioselective
transformations.
Underscoring
advances
applications
synthesis
various
heterocyclic
systems
total
natural
products
have
been
introduced.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(19), P. 14088 - 14095
Published: Sept. 12, 2023
A
mild
and
concise
method
for
the
synthesis
of
3-trifluoromethylpyrroles
via
base-mediated
[3
+
2]
cycloaddition
N-acyl
α-amino
acids
2-bromo-3,3,3-trifluoropropene
is
described.
N-Acyl
serve
as
1,3-dipole
precursors
without
additional
activating
agents
directly.
high
level
regioselectivity
was
observed,
regardless
electronic
nature
size
substituents
on
1,3-dipoles.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
Palladium-mediated,
ligand-promoted
C-H
fluorinated
olefination
of
aromatic
derivatives
is
reported
employing
2-bromo-3,3,3-trifluoropropene
(BTP)
as
the
fluorinating
reagent.
Bioactive
compounds,
such
Isatin,
exhibited
excellent
compatibility
with
this
reaction,
underscoring
significance
methodology
for
synthesis
important
derivatives.
Biomedicine and Chemical Sciences,
Journal Year:
2022,
Volume and Issue:
1(4), P. 234 - 240
Published: Oct. 1, 2022
In
this
short
review
definition,
mechanism,
and
recent
developments
of
the
Stetter
reaction,
in
period
last
ten
years
from
2011
to
2021
are
presented.
This
reaction
comprises
N-heterocyclic
carbene
(NHC)-catalyzed
umpolung
aldehydes
followed
by
their
capturing
with
activated
carbon-carbon
double
bonds
(Michael
acceptors).
work
includes
also
progresses
inter-molecular
intra-molecular
versions
enantioselective
transformations.
Underscoring
advances
applications
synthesis
various
heterocyclic
systems
total
natural
products
have
been
introduced.
