Iodine‐Mediated Three‐Component Strategy to Synthesize 2‐Aminothiazoles from β‐Diketones/β‐ketoesters, Arylamines and Ammonium Thiocyanate DOI
Abigail Philips,

Ajithkumar Arumugam,

Yuvaprabhu Eswaramoorthy

et al.

European Journal of Organic Chemistry, Journal Year: 2022, Volume and Issue: 2022(46)

Published: Nov. 10, 2022

Abstract A one‐pot, three‐component protocol for the synthesis of 2‐aminothiazoles promoted by iodine from readily available starting materials such as β‐diketones/β‐ketoesters, arylamines, and NH 4 SCN has been developed. wide range arylamines was tolerated well to produce expected polysubstituted in moderate good yields. The characteristic features this methodology include operational ease, metal‐free reaction conditions, gram‐scale scalability, functional group tolerance, short times.

Language: Английский

Recent Advances in Green Multi-Component Reactions for Heterocyclic Compound Construction DOI
Xinwei Shen, Gang Hong, Limin Wang

et al.

Organic & Biomolecular Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review highlights the recent advances in multi-component reactions for synthesizing heterocyclic compounds via green approaches including photoredox catalysis, electrochemical activation, catalyst-free methods and use of water as sole solvent.

Language: Английский

Citations

3
Recent advances in the application of alkynes in multicomponent reactions DOI Creative Commons
Seyedmohammad Hosseininezhad, Ali Ramazani

RSC Advances, Journal Year: 2024, Volume and Issue: 14(1), P. 278 - 352

Published: Jan. 1, 2024

The reactions and mechanisms of alkynes that are involved in multi-component through C–C C–H positions investigated.

Language: Английский

Citations

11
Recent advances in the dichalcogenation reactions of unsaturated compounds via double functionalization DOI
Chang‐Sheng Wang,

Yuan Xu,

Yiliang Zhou

et al.

Organic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 10(19), P. 4972 - 5027

Published: Jan. 1, 2023

This review comprehensively summarizes the dichalcogenative functionalization of unsaturated compounds over past decade. The scopes, limitations and detailed reaction mechanisms are also discussed.

Language: Английский

Citations

20
Recent advancements in metal‐catalyst‐free multicomponent radical sulfonylation of alkynes DOI
Rongnan Yi, Qiang Li, Hongxin Liu

et al.

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(43)

Published: June 4, 2024

Vinyl sulfones are crucial building blocks in synthetic chemistry and core structural units of pharmaceutically active molecules, thus extensive investigations have been conducted on the construction these skeletons. In contrast to classical approaches, radical sulfonylation alkynes for producing vinyl has garnered considerable interest because its mild conditions high efficiency. Radical sulfonation typically begins with sulfonyl attacking alkynes, followed by further functionalization. Moreover, association metal-catalyst-free systems multicomponent reactions (MCRs) offers an environmentally friendly pathway efficiently constructing complex scaffolds from readily available partners. However, there is no comprehensive review summarizing advancements alkynes. Hence, we provide a categorical overview based objects (hydrosulfonylation, carbosulfonylation, aminosulfonylation, oxysulfonylation, sulfosulfonylation, selenosulfonylation, iodosulfonylation), along interpretations reaction mechanisms.

Language: Английский

Citations

5
Photo-promoted radical cascade cyclization of 4-(allylamino)-3-cyanocoumarins: access to sulfonylated pyrido[3,2-c]coumarin derivatives DOI
Luyao Yang, Jun Ying, Hao Zheng

et al.

Green Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The first method for constructing pyrido[3,2- c ]coumarin derivatives via a radical cascade cyclization process was proposed, which can introduce active fragments.

Language: Английский

Citations

0
Visible‐light‐mediated synthesis of 3‐arylsulfonylated thioflavones using an in situ activation strategy DOI
Sangcheol Na, Anna Lee

Bulletin of the Korean Chemical Society, Journal Year: 2023, Volume and Issue: 44(11), P. 921 - 925

Published: Aug. 30, 2023

Abstract We have developed a visible‐light‐mediated synthesis of 3‐arylsulfonylated thioflavones using an in situ‐activation strategy. The reaction proceeds through one‐pot, three‐component pathway, without the need for sensitive or harsh conditions. Organic photocatalysts were employed to generate aryl radicals more efficiently from diazonium salts generated situ. This method enables amines and methylthiolated alkynones, utilizing potassium metabisulfite as inexpensive source sulfur dioxide. resulting products obtained under mild approach provides efficient alternative pathway synthesizing thioflavone derivatives, which are prevalent among various bioactive compounds.

Language: Английский

Citations

7
Selective synthesis of 2,3-dihydroquinazolin-4(1H)-ones and their N1-substituted analogues via Pd(II)-catalyzed cascade annulation of o-aminobenzoic acids with CO, ammonium acetate and aldehydes DOI
Xiaopeng Zhang,

Qiuyang Pang,

Dan Liú

et al.

Tetrahedron, Journal Year: 2024, Volume and Issue: 155, P. 133915 - 133915

Published: Feb. 22, 2024

Language: Английский

Citations

2
Recent Progress in Aryl Radical-Mediated Cyclization of Unsaturated Bonds Based on Aryldiazonium Salts DOI Open Access

Song Jiang,

Ning Nan,

Jinghao He

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2022, Volume and Issue: 42(12), P. 3959 - 3959

Published: Jan. 1, 2022

Aryldiazonium salts are widely used in organic synthesis due to their high reactivity and readily availability.As a common arylation reagent, aryl diazonium have been material chemistry, dye chemistry medicinal by retaining leaving N2 skeleton.In recent years, with the rapid development of radical cyclization reaction involving radicals, which produced aryldiazonium salts, has also developed rapidly, this strategy stimulates enthusiasm chemists construct various ring compounds.In review, addition unsaturated carbon-carbon bonds carbon-nitrogen cyclic compounds from radicals is summarized classified according size compounds.Finally, current research progress summarized.

Language: Английский

Citations

7
Iodine‐Mediated Three‐Component Strategy to Synthesize 2‐Aminothiazoles from β‐Diketones/β‐ketoesters, Arylamines and Ammonium Thiocyanate DOI
Abigail Philips,

Ajithkumar Arumugam,

Yuvaprabhu Eswaramoorthy

et al.

European Journal of Organic Chemistry, Journal Year: 2022, Volume and Issue: 2022(46)

Published: Nov. 10, 2022

Abstract A one‐pot, three‐component protocol for the synthesis of 2‐aminothiazoles promoted by iodine from readily available starting materials such as β‐diketones/β‐ketoesters, arylamines, and NH 4 SCN has been developed. wide range arylamines was tolerated well to produce expected polysubstituted in moderate good yields. The characteristic features this methodology include operational ease, metal‐free reaction conditions, gram‐scale scalability, functional group tolerance, short times.

Language: Английский

Citations

6