Progress in heterocyclic chemistry, Journal Year: 2023, Volume and Issue: unknown, P. 281 - 332
Published: Jan. 1, 2023
Language: Английский
Progress in heterocyclic chemistry, Journal Year: 2023, Volume and Issue: unknown, P. 281 - 332
Published: Jan. 1, 2023
Language: Английский
Organic & Biomolecular Chemistry, Journal Year: 2023, Volume and Issue: 21(15), P. 3101 - 3104
Published: Jan. 1, 2023
Herein, a Cu(II)-catalyzed facile construction of synthetically valuable spiro compounds from β-naphthols in air is reported, which N,N-dimethylaminoethanol (DMEA) serves as an efficient and unique C1 synthon. This transformation proceeds through ortho-quinone methide (o-QM) formation/Michael addition/dearomatization sequence, affording various spiro(naphthalenenaphtho)furan-2-ones moderate to excellent yields.
Language: Английский
Citations
24Organic Letters, Journal Year: 2023, Volume and Issue: 25(19), P. 3386 - 3390
Published: May 8, 2023
A [3 + 1 2] cyclization–rearrangement reaction scheme was developed to synthesize pyrimido[1,2-b]indazoles from aryl methyl ketones, 3-aminoindazoles, and gem-diarylethenes. This metal-free process proceeds via a sequential aza-Diels–Alder Wagner–Meerwein rearrangement, possible mechanism demonstrated based on control experiments. method exhibits good substrate compatibility allows simple conditions. Moreover, the products display significant aggregation-induced emission characteristics after modifications.
Language: Английский
Citations
20The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(6), P. 3941 - 3953
Published: Feb. 29, 2024
An efficient synthetic method for constructing 2,3- and 2,4-disubstituted pyrimidio[1,2-b]indazole skeletons through I2-DMSO-mediated substrate-controlled regioselective [4 + 2] cyclization is reported. The reaction conditions are mild, its operation simple, the substrate scope wide. More than 60 derivatives have been synthesized, providing a new methodology related molecules potentially enriching bioactive-molecule libraries.
Language: Английский
Citations
6Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(28), P. 5822 - 5826
Published: Jan. 1, 2024
One-step construction of both 5-arylpyrazolo[1,5- a ]pyrimidines and 2-arylpyrimido[1,2- b ]indazoles using inexpensive, abundant easy-to-handle calcium carbide as solid alkyne source is depicted.
Language: Английский
Citations
5Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(6), P. 1430 - 1435
Published: Jan. 23, 2024
Abstract A substrate‐induced synthesis of coumarin‐fused quinolinones is achieved from 4‐(phenylamino)‐2 H ‐chromen‐2‐ones using N ‐alkyl amines as the solvent and a carbon source under air conditions without any catalysts in one pot. This protocol highlights special roles which were not only used reactants but also an internal oxidant selectively activated ‐ α ‐C( sp 3 )−H bond. reaction features catalyst‐free, broad substrate scopes ( 27 examples 24 examples), operationally simple for one‐step synthesis, recovery recycling solvent.
Language: Английский
Citations
3Organic Chemistry Frontiers, Journal Year: 2022, Volume and Issue: 10(3), P. 780 - 785
Published: Dec. 9, 2022
Synthesis of multi-substituted pyridines and pyrroles was established involved C-N bond cleavage new C–N C–C formation. The adjacent to the primary carbon 1,2-diamino-2-methylpropane selectively cleaved.
Language: Английский
Citations
12ChemCatChem, Journal Year: 2024, Volume and Issue: unknown
Published: May 27, 2024
Abstract Nitrogen‐containing heterocycles represent fundamental components found in a myriad of natural compounds, pharmaceuticals, tailored bioactive substances, and agrochemicals. In recent decades, the field synthetic chemistry has prioritized these directing considerable research endeavour toward developing efficient concise methodologies for their synthesis. Consequently, there is growing interest pioneering novel approaches to fabricate immensely coveted structural motifs. Transition metal‐catalyzed reactions leveraging solvents as carbon (C1) synthons offer notable advantages, including streamlined processes, enhanced atom economy, environmental sustainability. This review sheds light on advancements utilization collective such methanol (alongside other alcohols), N,N ‐dimethylethanolamine (DMEA), triethylamine (TEA) (in conjunction with amines), tetrahydrofuran (THF), toluene, dichloromethane (DCM), dimethyl sulfoxide (DMSO), dimethylformamide (DMF) C1 synthons, serving foundational units synthesis N ‐heterocycles, quinazolinone, quinazoline, quinoxaline, pyridine, pyrimidine, among others. Various reaction conditions employing diverse transition metals, coupling partners, or reagents, reported literature, have been explored.
Language: Английский
Citations
2Synthesis, Journal Year: 2024, Volume and Issue: 56(12), P. 1932 - 1940
Published: Jan. 9, 2024
Abstract A simple and efficient method for the synthesis of 1,4-dihydropyridines from amines, N,N-dimethyl enaminone N,N-dimethylaminoethanol in a four-component [2+1+2+1] annulation catalyzed by FeCl3 has been established, where was applied as methine source. The procedure executed smoothly, resulting wide range with moderate to good yields. Additionally, these fluorophores exhibited photophysical characteristics.
Language: Английский
Citations
1European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(43)
Published: Aug. 3, 2024
Abstract Fused pyrimidines are a class of heterocyclic compounds that have gained considerable interest due to their extensive biological activities and potential applications in drug development. This review article aims provide comprehensive overview the latest synthetic approaches fused pyrimidines, including Michael reactions, multicomponent metal‐catalyzed photocatalytic peroxide‐mediated inverse electron demand Diels–Alder reactions. Furthermore, these compounds, such as ability combat cancer microbial infections, also discussed. summarizes existing literature on synthesis activity from 2020 2023. We hope this will inspire development more effective less toxic pyrimidine drugs with well‐designed structures.
Language: Английский
Citations
1Chemical Communications, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
The first synthesis of 3,4-diarylpyrimido[1,2- b ]indazole derivatives enabled by the epoxide-opening reaction with 3-aminoindazoles has been realized.
Language: Английский
Citations
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