Tetrabutylammonium Iodide-Mediated One-Pot Construction of 1,3,4-Oxadiazole Derivatives with Alkyl Amide and Hydrazine DOI

Zhixia Jing,

Jianxi Du,

Ping Jiang

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 43(11), P. 3930 - 3930

Published: Jan. 1, 2023

Language: Английский

Design, synthesis, olfactory evaluation and molecular docking study of Isoxazoline carboxylate derivatives as fragrance molecules DOI Creative Commons
Muhammet Büyükbayram,

Sonay Gürer,

Yeşim Çat

et al.

Flavour and Fragrance Journal, Journal Year: 2024, Volume and Issue: 39(3), P. 158 - 171

Published: Feb. 29, 2024

Abstract In this research, a wide range of aldoxime derivatives with aromatic and aliphatic substituents were synthesized as precursors to nitrile oxide in cycloaddition reactions. The aldoximes good high yields showed lack diastereoselectivity, confirmed by 1 H NMR measurements. These then utilized 1,3‐dipolar reactions treated dipolarophilic reagents, namely methyl methacrylate (MMA) glycidyl (GMA), produce isoxazoline carboxylate regioselectivity. obtained compounds characterized using various techniques, including NMR, FT‐IR, GC–MS TOF‐LCMS analyses. study also targets the molecular docking analysis, Autodock 4.2.6 software, targeting OR51E2 protein. This protein has drawn recent attention, hypothesis that propionic acid activates OR51E2, making it suitable candidate for group within skeleton. Through these multifaceted investigations, research contributes design development fragrant molecules potential applications fragrance industry, offering promising avenue future olfactory innovations.

Language: Английский

Citations

3
Copper‐catalyzed One‐pot Synthesis of 1,3,4‐Oxadiazol‐2(3H)‐ones Using DMF as the Carbonyl Source DOI
Ping Jiang, Qin Su, Keyume Ablajan

et al.

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(27)

Published: May 22, 2024

Abstract A series of 1,3,4‐oxadiazol‐2(3H)‐ones were prepared by an efficient copper‐catalyzed one‐pot reaction arylhydrazides, arylboronic acids and DMF. Moderate to good yield obtained using DMF as the carbonyl source aryl source. This involved ligand exchange transmetalation copper catalysts with arylhydrazides arylboric acids. Compared previous work, this work employs stable readily available hydrazide substrates that enhance practicality strategy, strategy features a short time, relatively low heating temperature, convenient more secure. Further, protocol has high functional group tolerance scalability.

Language: Английский

Citations

0
Five-membered ring systems with O and N atoms DOI
Franca M. Cordero, Donatella Giomi, Fabrizio Machetti

et al.

Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 275 - 308

Published: Jan. 1, 2024

Language: Английский

Citations

0
Recent New Developments in Hofmann, Curtius, Schmidt, Lossen, and Related Reactions DOI
Masato Matsugi,

Takayuki Shioiri

Elsevier eBooks, Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 1, 2023

Language: Английский

Citations

1
Tetrabutylammonium Iodide-Mediated One-Pot Construction of 1,3,4-Oxadiazole Derivatives with Alkyl Amide and Hydrazine DOI

Zhixia Jing,

Jianxi Du,

Ping Jiang

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 43(11), P. 3930 - 3930

Published: Jan. 1, 2023

Language: Английский

Citations

1