Molecules,
Journal Year:
2024,
Volume and Issue:
29(24), P. 6047 - 6047
Published: Dec. 22, 2024
Benzylic
C–H
oxidation
to
form
carbonyl
compounds,
such
as
ketones,
is
a
fundamental
transformation
in
organic
synthesis
it
allows
for
the
preparation
of
versatile
intermediates.
In
this
review,
we
highlight
aromatic
ketones
via
catalytic,
electrochemical,
and
photochemical
alkylarenes
using
different
catalysts
oxidants
past
5
years.
Additionally,
also
discuss
heterocyclic
molecules
benzylic
key
step.
These
methods
can
potentially
be
used
medicinal,
synthetic,
inorganic
chemistry.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(13), P. 2898 - 2918
Published: May 18, 2024
Abstract
Converting
any
desired
C−H
bond
to
the
intended
C−Z
in
a
given
organic
molecule
could
be
final
peak
of
functionalization
methodology.
Among
three
types
bonds,
ubiquitous
C(
sp
3
)−H
has
gained
particular
attention,
especially
last
two
decades.
There
are
different
ways
transform
bonds
into
bonds.
The
use
chlorine
radicals
is
one
these
methods
with
promising
future.
literature
review
shows
that
sources
have
been
used
for
chlorine,
including
chloride
ions
(HCl
or
salts),
coordinated
chlorides
(transition
metal
complexes),
and
(organochlorine
compounds).
However,
HCl
FeCl
most
attention
among
sources.
major
convert
from
radicals:
1)
oxidation
hydrogen
salts,
2)
photolysis
chloride,
3)
transition
insertion
C−Cl
This
summarizes
published
research
papers
on
functionalization.
Therefore,
chlorination
reactions
which
do
not
play
direct
role
cleavage
within
scope
this
review.
ACS Sustainable Chemistry & Engineering,
Journal Year:
2023,
Volume and Issue:
11(35), P. 13142 - 13148
Published: Aug. 24, 2023
Benzothiazolines,
with
their
versatile
nature,
serve
as
fundamental
building
blocks
for
the
synthesis
of
significant
biological
compounds.
However,
methods
preparation
benzothiazolines
from
readily
available
starting
materials
are
limited.
An
efficient
benzothiazoline
via
photoredox-catalyzed
dearomatization
benzothiazole
derivatives
has
been
achieved
at
room
temperature.
This
catalysis
proceeds
a
ligand
to
metal
charge
transfer
process,
and
FeCl3
plays
dual
role
an
indirect
HAT
reagent
reducing
agent.
methodology
can
be
conveniently
scaled
up,
most
alkylated
products
purified
without
chromatography.
In
addition,
this
process
exhibited
advantages
low
cost,
high
reaction
efficiency,
mild
conditions.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
89(1), P. 534 - 540
Published: Dec. 22, 2023
An
efficient
photocatalytic
oxidation
of
benzylic
C(sp3)–H
bonds
to
ketones,
esters,
and
amides
has
been
developed
using
NBS
as
a
metal-free
photocatalyst
O2
an
oxidant.
A
variety
synthetically
biologically
valuable
compounds
are
assembled
in
moderate
excellent
yields.
The
synthetic
utility
this
approach
demonstrated
by
gram-scale
experiments.
possible
free
radical
mechanism
was
proposed
rationalize
the
reaction
procedure.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(18), P. 4709 - 4717
Published: Jan. 1, 2023
Difluorinated
compounds
are
important
structural
motifs
in
organic
synthesis
and
medicinal
chemistry
because
fluoride
can
modulate
the
properties
of
various
molecules.
Green Synthesis and Catalysis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 1, 2024
A
practical,
metal-,
and
additive-free
strategy
for
photo-
electro-induced
perfluoroalkylation/cyclization
of
o-hydroxyaryl
enaminones
with
sodium
perfluoroalkanesulfinates
under
mild
conditions
has
been
developed.
Various
fluoroalkyl
chromones
were
efficiently
assembled
in
moderate
to
good
yields.
The
scalability
this
protocol
the
assembling
diverse
nitrogen-containing
heterocycles
from
late-stage
transformations
greatly
broaden
practical
applications
developed
protocol.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(32), P. 4310 - 4313
Published: Jan. 1, 2024
We
report
herein
a
mild
and
practical
photocatalytic
selective
oxidation
of
toluene
under
encapsulated
air
conditions
low
catalyst
loading,
while
simultaneously
accommodating
broad
applicability
for
various
high
value-added
aromatic
aldehydes.
Chemistry of Materials,
Journal Year:
2024,
Volume and Issue:
36(22), P. 11150 - 11159
Published: Nov. 9, 2024
Achieving
efficient
selective
visible
light-induced
oxidation
of
benzyl
C(sp3)–H
to
more
valuable
double-bonded
compounds
holds
significant
promise
for
organic
synthesis.
In
this
work,
we
fabricated
an
example
Ir
metalloligand-modified
POMOF
crystalline
material,
CI-SiW,
which
is
noteworthy
as
the
first
POM
immobilized
in
a
MOF
via
coordination
bonding.
Under
excitation
light
(10
W,
λ
=
410
nm),
CI-SiW
can
catalyze
isochromane
with
turnover
number
and
frequency
954
1740
h–1,
respectively.
Excitingly,
displays
best
TOF
compared
previous
photocatalysts
under
same
conditions,
realizing
maximum
yield
minimum
amount
photocatalyst.
Furthermore,
had
good
cyclic
structural
stability,
90.4%
was
still
obtained
after
three
reaction
cycles.
