BF3⋅Et2O‐Catalyzed Selective C‐4 Alkylation of Isoquinolin‐1(2H)‐ones Employing p‐Quinone Methides DOI
Devidas A. More, Ganesh S. Ghotekar,

M. Muthukrishnan

et al.

Chemistry - An Asian Journal, Journal Year: 2023, Volume and Issue: 18(17)

Published: July 14, 2023

The direct C-4 alkylation of isoquinolin-1(2H)-one moiety is a challenging transformation in organic synthesis. Here we present practical and efficient synthesis alkylated isoquinolin-1(2H)-ones through conjugate addition to p-quinone methides for the first time. process facilitated by Lewis acid catalysis this operationally straightforward, mild, metal-free one-pot provides wide range at ambient temperature good excellent yields.

Language: Английский

A ruthenium catalyzed Dolye–Kirmse rearrangement reaction of sulfoxonium ylides with sulfides or selenides DOI

Yingdi Hao,

Jiao Liang,

Zhiqian Lin

et al.

Organic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 10(16), P. 4038 - 4042

Published: Jan. 1, 2023

A ruthenium-catalyzed Dolye–Kirmse rearrangement reaction of sulfoxonium ylides to afford sulfide- or selenide-containing compounds has been developed.

Language: Английский

Citations

6
BF3⋅Et2O‐Catalyzed Selective C‐4 Alkylation of Isoquinolin‐1(2H)‐ones Employing p‐Quinone Methides DOI
Devidas A. More, Ganesh S. Ghotekar,

M. Muthukrishnan

et al.

Chemistry - An Asian Journal, Journal Year: 2023, Volume and Issue: 18(17)

Published: July 14, 2023

The direct C-4 alkylation of isoquinolin-1(2H)-one moiety is a challenging transformation in organic synthesis. Here we present practical and efficient synthesis alkylated isoquinolin-1(2H)-ones through conjugate addition to p-quinone methides for the first time. process facilitated by Lewis acid catalysis this operationally straightforward, mild, metal-free one-pot provides wide range at ambient temperature good excellent yields.

Language: Английский

Citations

1