Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(9), P. 2072 - 2078
Published: March 1, 2024
Abstract
A
photoinduced
direct
synthesis
of
3‐amino‐1‐indenones
via
radical
cascade
cyclization
strategy
is
demonstrated.
The
methodology
involves
a
domino
reaction
between
2‐alkynylarylnitrile
and
N
‐aminopyridinium
salt
captures
the
reactivity
in‐situ
generated
nitrogen‐centered
(NCR)
in
visible
light.
Multiple
bond‐forming
events
including
C−N,
C−C,
C−O
take
place
sequentially
on
enabling
construction
3‐amino‐1‐indenone
core
at
room
temperature
35–76%
yield.
preliminary
biological
screening
synthesized
compounds
indicative
their
potent
anti‐cancer
property.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 14, 2025
Thianthrenium
salts
have
emerged
as
one
of
the
most
versatile
reagents,
gaining
significant
popularity
within
synthetic
community
for
their
utility
in
construction
C-C
and
C-X
(X
=
N,
O,
S,
P,
halogens)
bonds.
The
use
photoredox
transition
metal
catalysis
with
thianthrenium
C-heteroatom
bond
formation
is
well
established.
However,
these
methods
require
elevated
temperatures,
expensive
catalysts,
ligands
under
stringent
conditions
effective
execution.
In
contrast,
photocatalysis-
transition-metal-free
approaches
constructing
bonds
using
salt
derivatives
become
increasingly
sought
after.
this
regard,
electron-donor-acceptor
(EDA)-complex
reactions
a
powerful
strategy
organic
synthesis,
eliminating
need
photocatalysts
visible
light
irradiation.
EDA-complex
photochemistry
exploits
electron-acceptor
properties
salts,
facilitating
rapid
generation
radical
intermediates
via
C-S
cleavage.
These
play
pivotal
role
enabling
variety
valuable
formations.
Perspective,
we
highlight
advances
EDA-complex-mediated
involving
mechanisms,
substrate
scope,
limitations
For
sake
brevity,
article
organized
into
five
main
sections:
(1)
Nitrogen-based
donor
reactions,
(2)
Oxygen-based
(3)
Sulfur-based
(4)
Phosphorus-based
(5)
π-based
focus
on
C-C,
C-S,
C-B
C-P
ChemPhotoChem,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 25, 2025
Over
the
past
decades,
visible‐light‐driven
reactions
have
emerged
as
a
powerful
tool
in
organic
synthesis.
Unlike
traditional
photoredox
that
require
additional
catalysts
or
photosensitizers,
electron
donor–acceptor
(EDA)
complex‐mediated
photochemistry
offers
simpler
and
more
cost‐effective
approach
to
achieving
diverse
radical
transformations
without
need
for
noble
catalysts.
Among
these,
use
of
boron‐containing
compounds
donors
acceptors
EDA
complexes
has
garnered
significant
attention
due
their
unique
properties.
This
review
highlights
recent
advances
visible‐light‐induced
involving
compounds,
focusing
on
applications
constructing
CC
CB
bonds
elucidating
underlying
reaction
mechanisms.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(9), P. 2072 - 2078
Published: March 1, 2024
Abstract
A
photoinduced
direct
synthesis
of
3‐amino‐1‐indenones
via
radical
cascade
cyclization
strategy
is
demonstrated.
The
methodology
involves
a
domino
reaction
between
2‐alkynylarylnitrile
and
N
‐aminopyridinium
salt
captures
the
reactivity
in‐situ
generated
nitrogen‐centered
(NCR)
in
visible
light.
Multiple
bond‐forming
events
including
C−N,
C−C,
C−O
take
place
sequentially
on
enabling
construction
3‐amino‐1‐indenone
core
at
room
temperature
35–76%
yield.
preliminary
biological
screening
synthesized
compounds
indicative
their
potent
anti‐cancer
property.
