Copper(I)‐Catalyzed [4+2] Oxidative Annulation of α,β‐Unsaturated Ketoxime Acetates with Cyclopropanols toward Functional Pyridines DOI

Qinghuan Wu,

Gaochen Xu,

Yuguang Li

et al.

Advanced Synthesis & Catalysis, Journal Year: 2023, Volume and Issue: 365(23), P. 4310 - 4316

Published: Nov. 3, 2023

Abstract A Cu(I)‐catalyzed [4+2] oxidative annulation of α , β ‐unsaturated ketoxime acetates with cyclopropanols has been developed for the synthesis 2,4,5‐trisubstituted pyridines in 28–76% yields. This method employs as C2 synthons and features various functional group compatibility gram‐scale synthesis. In addition, a plausible reaction pathway was proposed based on mechanism studies.

Language: Английский

Copper(I)‐Catalyzed [4+2] Oxidative Annulation of α,β‐Unsaturated Ketoxime Acetates with Cyclopropanols toward Functional Pyridines DOI

Qinghuan Wu,

Gaochen Xu,

Yuguang Li

et al.

Advanced Synthesis & Catalysis, Journal Year: 2023, Volume and Issue: 365(23), P. 4310 - 4316

Published: Nov. 3, 2023

Abstract A Cu(I)‐catalyzed [4+2] oxidative annulation of α , β ‐unsaturated ketoxime acetates with cyclopropanols has been developed for the synthesis 2,4,5‐trisubstituted pyridines in 28–76% yields. This method employs as C2 synthons and features various functional group compatibility gram‐scale synthesis. In addition, a plausible reaction pathway was proposed based on mechanism studies.

Language: Английский

Citations

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