Recent Progress on Methods for the Preparation of Mono/Di/Trifluoromethoxylation Reagents DOI
Wei Zheng,

Fengzheng Liu,

Hongqiong Zhao

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 44(11), P. 3321 - 3321

Published: Jan. 1, 2024

Language: Английский

Copper(I) Iodide-Catalyzed Perfluoroalkoxylation Reaction of Alkyl Halides DOI

Xiong Wu,

Bingjun Le,

Wangchuan Xiao

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(34), P. 7139 - 7143

Published: Aug. 15, 2024

We report an efficient perfluoroalkoxylation reaction of alkyl halides catalyzed by copper(I) iodide (CuI), which facilitates the simultaneous activation both perfluoroalkoxide and halides. This methodology is tolerant a wide range functional groups eliminates need for costly metal reagents. The conducted in single step under mildly practical conditions.

Language: Английский

Citations

1
Synthesis of Ngai Reagent and Longer Carbon Chain Variants for Perfluoroalkoxylations DOI

Koki Kawai,

Sota Ikawa,

Naoyuki Hoshiya

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

We present a straightforward method for the synthesis of Ngai trifluoromethoxy reagent and longer carbon chain variants, thereby expanding range options perfluoroalkoxylation reactions. Utilizing cost-effective sodium perfluoroalkane sulfinates (R

Language: Английский

Citations

1
Recent Uses of Photogenerated Oxygen-Centered Radicals in Intermolecular C–O Bond Formation DOI
Guillaume Dagousset,

Camille Banoun,

Emmanuel Magnier

et al.

Synlett, Journal Year: 2023, Volume and Issue: 35(03), P. 268 - 278

Published: July 18, 2023

Abstract We report herein recent advances made by our group and others in the field of oxygen-centered radicals generated under photocatalysis. Thanks to design new O-radical precursors, these can now be efficiently trapped unsaturated systems an intermolecular manner, via formation a C–O bond. 1 Introduction 2 Reactions Involving Carbonyloxy Radicals 3 Fluoroalkoxy 4 Alkoxy 5 Conclusion

Language: Английский

Citations

2
2,2‐Difluoroethylation of Heteroatom Nucleophiles via a Hypervalent Iodine Strategy DOI Creative Commons
Suman Das,

Charlotte McIvor,

Andrew Greener

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(40)

Published: June 20, 2024

Abstract The 2,2‐difluoroethyl group is an important lipophilic hydrogen bond donor in medicinal chemistry, but its incorporation into small molecules often challenging. Herein, we demonstrate electrophilic 2,2‐difluoroethylation of thiol, amine and alcohol nucleophiles with a hypervalent iodine reagent, (2,2‐difluoro‐ethyl)(aryl)iodonium triflate, via proposed ligand coupling mechanism. This transformation offers complementary strategy to existing methods allows access wide range 2,2‐difluoroethylated nucleophiles, including the drugs Captopril, Normorphine Mefloquine.

Language: Английский

Citations

0
Advances in the Synthesis of Mono/Di/Polyfluoroalkyl Ethers DOI
Dongxue Song,

Hongqiong Zhao,

Ying Xu

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 44(7), P. 2174 - 2174

Published: Jan. 1, 2024

Language: Английский

Citations

0
Introduction of Fluorinated Groups via Photoredox-Catalyzed C–H Functionalization of (Hetero-)Arenes DOI
Sourav Manna,

Pierpaolo Satta,

Lukas J. Gooßen

et al.

Synlett, Journal Year: 2024, Volume and Issue: unknown

Published: July 31, 2024

Abstract In recent years, there have been increasing efforts in the development of methodologies for incorporating fluorine-containing functional groups into organic scaffolds. Modern techniques made fluorinated molecules more accessible than ever before, but many fluorination reactions still limitations their generality, predictability, sustainability, and cost-effectiveness. The methodological progress has a significant impact on drug discovery materials science research. Photoredox catalysis enabled effective methods, providing access to druglike molecules. Photochemical methods paired with C–H functionalization provide powerful tools property-driven Herein, we examine developments at interface photoredox functionalization. 1 Introduction 2 Fluorinations 3 Fluoroalkylations 4 Fluoroalkoxylations 5 Conclusion

Language: Английский

Citations

0
Recent Progress on Methods for the Preparation of Mono/Di/Trifluoromethoxylation Reagents DOI
Wei Zheng,

Fengzheng Liu,

Hongqiong Zhao

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 44(11), P. 3321 - 3321

Published: Jan. 1, 2024

Language: Английский

Citations

0