Reduction of C O to CHOH by Metal-Catalyzed Hydrogenation and Transfer Hydrogenation DOI
Lijin Xu, Xin Xu, Huanrong Li

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Bimetallic Ru/Ru‐Catalyzed Asymmetric One‐Pot Sequential Hydrogenations for the Stereodivergent Synthesis of Chiral Lactones DOI Creative Commons

Jingli He,

Zhaodi Li,

Ruhui Li

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(23)

Published: March 21, 2024

Abstract Asymmetric sequential hydrogenations of α ‐methylene γ ‐ or δ ‐keto carboxylic acids are established in one‐pot using a bimetallic Ru/Ru catalyst system, achieving the stereodivergent synthesis all four stereoisomers both chiral and ‐lactones with two non‐vicinal carbon stereocenters high yields (up to 99%) excellent stereoselectivities >99% ee >20:1 dr). The compatibility Ru systems is investigated detail, it found that basicity reaction system plays key role hydrogenation processes. protocol can be performed on gram‐scale low loading 11000 S/C) resulting products allow for many transformations, particularly several intermediates useful preparation drugs natural products.

Language: Английский

Citations

8
Ru-Catalyzed Asymmetric Hydrogenation of α,β-Unsaturated γ-Lactams DOI

Zheng‐Dong Ding,

Yicong Luo, Qianjia Yuan

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(36), P. 25312 - 25320

Published: Sept. 2, 2024

A highly efficient Ru-catalyzed asymmetric hydrogenation of α,β-unsaturated γ-lactams has been developed by using a

Language: Английский

Citations

6
Effect of Solvents on Electrogenerated Base-Driven Transfer Hydrogenation Reactions DOI Creative Commons
Jingwei Zhu, Menghan Li, Feng Zhang

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 910 - 910

Published: Feb. 15, 2025

Transfer hydrogenation is a crucial technology for synthesizing fine chemicals and pharmaceuticals, offering improved safety convenience over traditional hydrogen methods, although it typically requires external bases. While isopropanol commonly used as source, methanol superior but faces challenges due to its high dehydrogenation energy barrier, limiting use under mild conditions. This study focuses on investigating the differences in electrogenerated base-driven transfer of aromatic ketones solvents, using Mn(CO)₅Br cyclohexanediamine derivatives catalyst. The research demonstrates that enantiomeric excess (ee) values were obtained presence chiral Mn-based catalysts, while only racemic products observed methanol. results indicate strong dependence catalytic pathway choice solvent: isopropanol, catalyst operates via metal-ligand cooperative hydrogenation, resulting ee values, whereas methanol, occurs through metal hydride with no stereoselectivity.

Language: Английский

Citations

0
RuPHOX-Ru catalyzed asymmetric Guerbet reaction of secondary alcohols with primary alcohols DOI

Jingli He,

Ruhui Li,

Xuezhen Kou

et al.

Tetrahedron, Journal Year: 2023, Volume and Issue: 143, P. 133543 - 133543

Published: July 11, 2023

Language: Английский

Citations

4
Manganese catalyzed asymmetric transfer hydrogenation of hindered ketones bearing a 2,6-disubstituted phenyl group DOI
Lixian Wang, Qiangsheng Sun,

Bingyang Wang

et al.

Journal of Catalysis, Journal Year: 2024, Volume and Issue: 438, P. 115680 - 115680

Published: July 31, 2024

Language: Английский

Citations

1
RuPHOX‐Ru Catalyzed Asymmetric Cascade Hydrogenation of 3‐Substituted Chromones for the Synthesis of Corresponding Chiral Chromanols DOI
Shaofeng Xu,

Wenqi Xu,

Siqi Dong

et al.

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(37)

Published: May 2, 2024

Abstract An efficient RuPHOX−Ru catalyzed asymmetric cascade hydrogenation of 3‐substituted chromones has been achieved under mild reaction conditions, affording the corresponding chiral chromanols in high yields with excellent enantio‐ and diastereoselectivities (up to 99 % yield, >99 ee >20 : 1 dr). Control reactions deuterium labelling experiments revealed that a dynamic kinetic resolution process occurs during subsequent C=O double bond, which is responsible for performance hydrogenation. The resulting products allow several transformations it was shown protocol provides practical alternative strategy synthesis their derivatives.

Language: Английский

Citations

0
Reduction of C O to CHOH by Metal-Catalyzed Hydrogenation and Transfer Hydrogenation DOI
Lijin Xu, Xin Xu, Huanrong Li

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

0