Continuous-Flow Photobromination/Debromination Cascade for Synthesis of the Trifloxystrobin Intermediate DOI
Fujun Li,

Peihao Cheng,

Xinghai Li

et al.

Industrial & Engineering Chemistry Research, Journal Year: 2024, Volume and Issue: 63(42), P. 17734 - 17743

Published: Oct. 9, 2024

Bromination reactions involving bromine monomers tend to be polybrominated, resulting in poor product selectivity and subsequent separation difficulties. This proposal outlines a multistep cascade for continuous flow synthesis photobromination debromination. The process comprises five units: generation, photobromination, quenching, water/oil separation, photodebromination. A full-process efficient of the trifluorostrolibin intermediate (E)-Methyl-2-(2-broMoMethylphenyl)-2-MethoxyiMinoacetate (MBPA) was achieved. converts byproduct (E)-Methyl-2-(2-dibroMoMethylphenyl)-2-MethoxyiMinoacetate into target MBPA. At total residence time 12.9 min, conversion (E)-Methy-2-(methoxyimino)-2-(o-toly) acetate reached 99.0%, yield MBPA 94.2%. Machine learning quantum chemical calculations enhance comprehension photodebromination mechanisms. Simultaneously, through comprehensive simulations sensitivity scenario analyses, optimization photon utilization emerged as pivotal factor improving overall applicability production process. method synthesizing halogenated products is anticipated play crucial role pharmaceuticals or pesticides.

Language: Английский

Advances in cofactor immobilization for enhanced continuous-flow biocatalysis DOI Creative Commons
Bente Reus, Matteo Damian, Francesco G. Mutti

et al.

Journal of Flow Chemistry, Journal Year: 2024, Volume and Issue: 14(1), P. 219 - 238

Published: Feb. 14, 2024

Abstract The merging of biocatalysis with continuous-flow chemistry opens up new opportunities for sustainable and efficient chemical synthesis. Cofactor-dependent enzymes are essential various industrially attractive biocatalytic reactions. However, implementing these reactions in industry remains challenging due to the inherent cost cofactors requirement their external supply significant quantities. development efficient, low cost, simple versatile methods cofactor immobilization can address this important obstacle flow. This review explores recent progress by analyzing advantages current limitations available that comprise covalent tethering, ionic adsorption, physical entrapment, hybrid variations thereof. Moreover, analyzes all techniques specifically utilization provides a perspective future work area. will serve as guide steering field towards more economically viable biocatalysis. Graphical

Language: Английский

Citations

12
Waste Valorization in a Sustainable Bio‐Based Economy: The Road to Carbon Neutrality DOI Creative Commons
Roger A. Sheldon

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 6, 2024

Abstract The development of sustainable chemistry underlying the quest to minimize and/or valorize waste in carbon‐neutral manufacture chemicals is followed over last four five decades. Both chemo‐ and biocatalysis have played an indispensable role this odyssey. particular developments protein engineering, metagenomics bioinformatics preceding three decades a crucial supporting facilitating widespread application both whole cell cell‐free biocatalysis. pressing need, driven by climate change mitigation, for drastic reduction greenhouse gas (GHG) emissions, has precipitated energy transition based on decarbonization defossilization organic production. latter involves biomass CO 2 as feedstock green electricity generated using solar, wind, hydroelectric or nuclear energy. use polysaccharides feedstocks will underpin renaissance carbohydrate with pentoses hexoses base bio‐based solvents polymers environmentally friendly downstream products. availability inexpensive solar led increasing attention electro(bio)catalysis photo(bio)catalysis which turn leading myriad innovations these fields.

Language: Английский

Citations

5
Continuous‐Flow Photochemistry: The Synthesis of Marketed Pharmaceutical Compounds DOI
Vishal Srivastava, Praveen P. Singh, Surabhi Sinha

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(47)

Published: Dec. 1, 2024

Abstract Chemistry professionals from all kinds of fields and disciplines in the academic commercial sectors have recently shown a great deal interest continuous‐flow chemistry. Flow methods are used nowadays for rapid optimization assessment, as well production scale‐up, reaction discovery, methodology. Photochemical processes currently receiving lot attention scientific community, application flow these approaches has advantages chemistry its importance modern industry worldwide. This study illustrates most recent advancements benefits continuous photochemical reactions relation to synthesis active pharmaceutical compounds recommended frameworks.

Language: Английский

Citations

2
Multiple Strategies Enhance 7-Dehydrocholesterol Production from Kitchen Waste by Engineered Yarrowia lipolytica DOI
Tianyu Dong, Xiao Zhou,

Zheng-Jie Hou

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

7-Dehydrocholesterol (7-DHC) is an important precursor of vitamin D

Language: Английский

Citations

2
Continuous Flow Chemistry: A Novel Technology for the Synthesis of Marine Drugs DOI Creative Commons
Laura Fernández-Peña, Paula González-Andrés,

Lucía G. Parte

et al.

Marine Drugs, Journal Year: 2023, Volume and Issue: 21(7), P. 402 - 402

Published: July 13, 2023

In this perspective, we showcase the benefits of continuous flow chemistry and photochemistry how these valuable tools have contributed to synthesis organic scaffolds from marine environment. These technologies not only facilitated previously described synthetic pathways, but also opened new opportunities in preparation novel molecules with remarkable pharmacological properties which can be used drug discovery programs.

Language: Английский

Citations

5
Coupling photocatalytic trifluoromethylation with biocatalytic stereoselective ketone reduction in continuous flow DOI Creative Commons
Alessia Valotta,

Julia Maderbacher,

Tamara Reiter

et al.

Chemical Papers, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 12, 2024

Language: Английский

Citations

1
Efficient synthesis of vitamin D<sub>3</sub> in a 3D ultraviolet photochemical microreactor fabricated using an ultrafast laser DOI Open Access
Aodong Zhang, Jian Xu, Lingling Xia

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 5(1), P. 1 - 1

Published: Jan. 1, 2024

Language: Английский

Citations

0
Recent advances in polyoxometalates based strategies for green synthesis of drugs DOI
Tengteng Wang,

Yiming Ju,

Cheng Yao

et al.

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 109871 - 109871

Published: April 1, 2024

Language: Английский

Citations

0
Continuous-Flow Photobromination/Debromination Cascade for Synthesis of the Trifloxystrobin Intermediate DOI
Fujun Li,

Peihao Cheng,

Xinghai Li

et al.

Industrial & Engineering Chemistry Research, Journal Year: 2024, Volume and Issue: 63(42), P. 17734 - 17743

Published: Oct. 9, 2024

Bromination reactions involving bromine monomers tend to be polybrominated, resulting in poor product selectivity and subsequent separation difficulties. This proposal outlines a multistep cascade for continuous flow synthesis photobromination debromination. The process comprises five units: generation, photobromination, quenching, water/oil separation, photodebromination. A full-process efficient of the trifluorostrolibin intermediate (E)-Methyl-2-(2-broMoMethylphenyl)-2-MethoxyiMinoacetate (MBPA) was achieved. converts byproduct (E)-Methyl-2-(2-dibroMoMethylphenyl)-2-MethoxyiMinoacetate into target MBPA. At total residence time 12.9 min, conversion (E)-Methy-2-(methoxyimino)-2-(o-toly) acetate reached 99.0%, yield MBPA 94.2%. Machine learning quantum chemical calculations enhance comprehension photodebromination mechanisms. Simultaneously, through comprehensive simulations sensitivity scenario analyses, optimization photon utilization emerged as pivotal factor improving overall applicability production process. method synthesizing halogenated products is anticipated play crucial role pharmaceuticals or pesticides.

Language: Английский

Citations

0