Advances in Self-Organized Total Synthesis of Natural Products DOI
Lisheng Wang, Jia‐Chen Xiang, An‐Xin Wu

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

In this review, we account for the definition, delimitation, and categorization of self-organized total synthesis then elucidate a comprehensive understanding synthetic strategy based on our intensive explorations.

Language: Английский

Photoredox streamlines electrocatalysis: photoelectrosynthesis of polycyclic pyrimidin-4-ones through carbocyclization of unactivated alkenes with malonates DOI

Minglin Tao,

Feng Qin,

Kaixing Gong

et al.

Green Chemistry, Journal Year: 2024, Volume and Issue: 26(7), P. 4199 - 4208

Published: Jan. 1, 2024

A new photoelectrocatalytic mode permits the synthesis of polycyclic pyrimidin-4-ones through dehydrogenative cyclization malonates with unactivated alkenes.

Language: Английский

Citations

15
Electrochemical Promoted Three-Component Trifluoromethylation/Spirocyclization Reaction of N-Arylsulfonylacrylamides to 4-Azaspiro[4.5]decanes DOI

Zhi-Long Lei,

Tai-Chen Liu,

Fei‐Hu Cui

et al.

Organic Letters, Journal Year: 2023, Volume and Issue: 25(32), P. 6001 - 6005

Published: Aug. 7, 2023

An electrochemical facilitated three-component trifluoromethylation/spirocyclization reaction of N-(arylsulfonyl)acrylamides, CF3SO2Na, and H2O has been developed. Without the requirement chemical oxidants, a number unexplored trifluoromethylated 4-azaspiro[4.5]decanes were obtained in satisfactory yields under mild conditions. This work provides new synthetic strategy for fluorine-containing spirocyclic compounds shows perspective reactivity study N-(arylsulfonyl)acrylamides.

Language: Английский

Citations

11
Electrochemical [3+3] Annulation of Phenol and Hydrazone: Synthesis of 1,3,4-Oxadiazines DOI
Jiahui Zhang, Yang‐Yang Hu,

Yuge Ran

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

A novel [3+3] cyclization reaction between phenol and hydrazone was successfully developed under electrochemically driven conditions. This provided access to a diverse array of 1,3,4-oxadiazinane compounds in consistently high yields, reaching up 87%. Notably, the exhibited remarkable tolerance toward broad spectrum both substrates, underscoring its versatility. Moreover, protocol distinguished itself by exceptional atom step economy, facilitating efficient construction functionalized 1,3,4-oxadiazines. The synthetic utility this approach further exemplified scalability, as demonstrated gram-scale reactions, substrate scope.

Language: Английский

Citations

0
The Aza-Diels-Alder Reaction Between Cyclic Imine and Aza-ortho-quinone Methide Precursor to Access Polycyclic-fused Tetrahydroquinazoline DOI
Xiaoke Zhang, Lu He, Xuan Zhang

et al.

Tetrahedron, Journal Year: 2025, Volume and Issue: unknown, P. 134665 - 134665

Published: April 1, 2025

Language: Английский

Citations

0
Electrosynthesis of Quinoxalines via Intermolecular Cyclization/Dehydrogenation of Ketones with o-Phenylenediamines DOI Creative Commons
Lei Liu, Tao Yi, Jiahui Zhang

et al.

Synlett, Journal Year: 2024, Volume and Issue: unknown

Published: June 5, 2024

Abstract In this study, we proposed a novel electrochemical dehydrogenative synthetic method for preparing 2-substituted quinoxalines by intermolecular cyclization of aryl alkyl ketones and o-phenylenediamines. This gave various in yields ranging from 35% to 71%. protocol employs mild reaction conditions offers moderate excellent yields, wide substrate scope, broad functional-group compatibility. Furthermore, late-stage functionalization the scope demonstrated utility protocol.

Language: Английский

Citations

2
Visible-light promoted radical cascade cyclization of 3-allyl-2-arylquinazolinones for the synthesis of phosphorylated dihydroisoquinolino[1,2-b]quinazolinones DOI
Jun Huang,

Caijin Ban,

J. J. Qin

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(62), P. 8119 - 8122

Published: Jan. 1, 2024

A novel visible-light promoted metal-free radical cascade cyclization reaction has been developed with 3-allyl-2-arylquinazolinones as a new class of acceptor. This photocatalytic protocol represents an efficient approach to construct phosphorylated dihydroisoquinolino[1,2-

Language: Английский

Citations

1
Photoredox/HAT-Catalyzed Intramolecular Hydrocyclization of Alkenes toward 2,3-Fused Quinazolinones and Dihydroquinazolinones DOI
Dong Li,

Xiaoqing Wang,

Yanhui Gou

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 2, 2024

New photochemical approaches to 2,3-fused quinazolinones and dihydroquinazolinones are disclosed. The intramolecular hydrocyclization proceeds in moderate excellent yields across diverse alkenes with high regioselectivity diastereocontrol. Mechanistic studies indicated that the radical cascade processes involve thiophenol acting as single-electron transfer hydrogen atom reagents. success of gram-scale synthesis proves strategy can be used for practical applications.

Language: Английский

Citations

1
De novo synthesis of 6-6-5 fused-systems through electrochemical decarboxylation and radical domino additions DOI

Chengcheng Yuan,

Guanru Liu,

Wenjing Guan

et al.

Green Chemistry, Journal Year: 2024, Volume and Issue: 26(19), P. 10308 - 10313

Published: Jan. 1, 2024

An oxidant and quaternary ammonium salt-free electrosynthesis of 6-6-5 fused systems was developed with excellent atom step economy.

Language: Английский

Citations

1
Unveiling the role of Lewis bases in cascade furan Diels–Alder cycloadditions: asymmetric synthesis of polycyclic quinazolinones DOI
Yuhan Li, Dongyi Zhang, Zhonglin Wei

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(19), P. 5488 - 5494

Published: Jan. 1, 2024

A Lewis base catalyzed asymmetric substitution/IMDAF reaction for the synthesis of polycyclic quinazolinones has been developed. The key role in IMDAF process unveiled.

Language: Английский

Citations

0
Advances in Self-Organized Total Synthesis of Natural Products DOI
Lisheng Wang, Jia‐Chen Xiang, An‐Xin Wu

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

In this review, we account for the definition, delimitation, and categorization of self-organized total synthesis then elucidate a comprehensive understanding synthetic strategy based on our intensive explorations.

Language: Английский

Citations

0