Metallaphotocatalytic triple couplings for modular synthesis of elaborate N-trifluoroalkyl anilines DOI Creative Commons
Ting Zhou, Zhongwei Zhang, Jing Nie

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 15, 2024

Abstract The integration of trifluoromethyl groups and three-dimensional quaternary carbon moieties into organic molecules has emerged as a prominent strategy in medicinal chemistry to augment drug efficacy. Although (hetero)aromatic amines derivatives are prevalent frameworks pharmaceuticals, the development trifluoromethyl-embedded, intricately structured alkyl amine scaffolds for research remains significant challenge. Herein, we present metallaphotoredox multicomponent amination employing 3,3,3-trifluoropropene, nitroarenes, tertiary alkylamines, carboxylic acids. This synthetic pathway offers notable advantages, including accessibility cost-effectiveness starting materials, high levels chemo- regioselectivity, modularity. Furthermore, this approach enables synthesis broad spectrum aniline compounds featuring both group distal motifs along aliphatic chains. accelerated access such elaborate N -trifluoroalkyl anilines likely involves three sequential radical-mediated coupling events, providing insightful implications retrosynthesis potential discovery.

Language: Английский

Metallaphotocatalytic modular synthesis of masked arylaminomethyl trifluoromethyl ketones DOI Creative Commons
Yingde Jiang, Zhongwei Zhang, Chi Wai Cheung

et al.

Cell Reports Physical Science, Journal Year: 2025, Volume and Issue: unknown, P. 102564 - 102564

Published: April 1, 2025

Language: Английский

Citations

0
Metallaphotocatalytic triple couplings for modular synthesis of elaborate N-trifluoroalkyl anilines DOI Creative Commons
Ting Zhou, Zhongwei Zhang, Jing Nie

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 15, 2024

Abstract The integration of trifluoromethyl groups and three-dimensional quaternary carbon moieties into organic molecules has emerged as a prominent strategy in medicinal chemistry to augment drug efficacy. Although (hetero)aromatic amines derivatives are prevalent frameworks pharmaceuticals, the development trifluoromethyl-embedded, intricately structured alkyl amine scaffolds for research remains significant challenge. Herein, we present metallaphotoredox multicomponent amination employing 3,3,3-trifluoropropene, nitroarenes, tertiary alkylamines, carboxylic acids. This synthetic pathway offers notable advantages, including accessibility cost-effectiveness starting materials, high levels chemo- regioselectivity, modularity. Furthermore, this approach enables synthesis broad spectrum aniline compounds featuring both group distal motifs along aliphatic chains. accelerated access such elaborate N -trifluoroalkyl anilines likely involves three sequential radical-mediated coupling events, providing insightful implications retrosynthesis potential discovery.

Language: Английский

Citations

1