Visible-Light-Mediated Addition Reactions of Sulfur-Containing Reagents with α-Trifluoromethyl Alkenes

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Herein, we described the addition reactions of sulfur-containing reagents (sodium sulfinates, dithiosulfonates) with α-trifluoromethyl alkenes under visible light. A series trifluoromethyl sulfonates were synthesized via visible-light-induced radical reaction sodium sulfinates and to obtain protons from solvent. dithiosulfonated derivatives bifunctionalization dithiosulfonates.This strategy has advantages mild conditions, good substrate universality high yield up 99% yield.

Language: Английский

Asymmetric Fluorocyclization of Difluoroalkenes with Concomitant Formation of a Trifluoromethyl Group

Organic Letters, Journal Year: 2024, Volume and Issue: 26(8), P. 1723 - 1727

Published: Feb. 21, 2024

Asymmetric electrophilic fluorination of difluoroalkenes remains undeveloped because the poor reactivity with electrophiles. However, such reactions, if feasible, are expected to be useful for synthesis chiral heterocyclic compounds a trifluoromethyl group at stereogenic center. In this Letter, we disclose first example asymmetric fluoroamide cyclization using our dianionic phase-transfer catalyst. This reaction provides unique trifluoromethylated oxazoline derivatives synthetically level.

Language: Английский

Sulfone as traceless activating group: divergent synthesis of α-fluoroamides with C–F quaternary stereocenters

Green Synthesis and Catalysis, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский