HFIP-Promoted Divergent Cycloadditions of Difluoroenoxysilanes with 2-Indolylmethanols: Synthesis of Fluoro 2H-Pyrano[3,4-b]indoles and gem-Difluoro Cyclopenta[b]indoles

Organic Letters, Journal Year: 2024, Volume and Issue: 26(22), P. 4610 - 4615

Published: May 23, 2024

An oxa-6π-electrocyclization of difluoroenoxysilanes with diaryl 2-indolylmethanols has been developed. In addition, a rarely reported C3-nucleophilic [3+2] cycloaddition dialkyl disclosed. This divergent approach affording readily available as three-atom and C2 synthons provides rapid access to fluoro 2

Language: Английский

Photocatalytic α‐Difluoroalkoxyketones Synthesis via Radical Intermolecular Alkoxylation of Difluoroenol Silyl Ethers

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(16), P. 3500 - 3504

Published: June 27, 2024

Abstract We present a metal‐free photocatalytic approach for the synthesis of difluoroalkoxylatedketones. This strategy involves generation alkoxyl radicals from pyridinium salts upon activity catalytic electron‐donor‐acceptor (EDA) complex. mild process tolerates several functional groups and can be scaled up to gram scale. Diverse products manipulations accounts versatility obtained fluorinated products, highlighting synthetic usefulness this method.

Language: Английский