Copper-Catalyzed Domino Annulation of Isoselenocyanates: A Pathway to Structurally Diverse N, Se-Bis-Heterocyclic, and Fused Heterocyclic Compounds

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

A copper-catalyzed domino addition/cyclization reaction was developed to synthesize novel benzoselenazole-linked 1,2,3-triazole and tetracyclic fused 12H-benzo[4,5]selenazole[2,3-b]quinazolin-12-one derivatives from isoselenocyanates. This efficiently constructed multiple new chemical bonds in a single step, forming either four (one C–Se three C–N) or two bonds. The offers several key advantages, including mild conditions, broad substrate compatibility, straightforward safe operation. It presents method for synthesizing N, Se-containing polycyclic compounds, which have potential interest medicinal chemistry. Notably, some of the synthesized compounds exhibited anticancer activity with IC50 values below 20 μmol L–1 against T24 human bladder cancer cells.

Language: Английский

Palladium Catalysis: Dependence of the Efficiency of C–N Bond Formation on Carboxylate Ligand and Metal Carboxylate or Carboxylic Acid Additive

ACS Omega, Journal Year: 2024, Volume and Issue: unknown

Published: March 8, 2024

The Pd-catalyzed inter- and intramolecular reactions of nitrogen compounds are often carried out with palladium carboxylates, sometimes in the presence carboxylic acids or alkali metal carboxylates. This Mini-Review highlights dependence reaction efficiency on nature ligand carboxylate additives. proposed mechanisms presented with, as far possible, personal comments.

Language: Английский