Synthesis of Tetracyclic-Fused Dihydroindeno[2,1-b]chromenes via Palladium-Catalyzed Alkyne Insertion and C–H Bond Activation DOI
Wenting Guo, Wenting Wu,

X.‐C. WANG

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

An unprecedented Pd-catalyzed cascade alkyne insertion/Heck/C–H activation reaction of o-iodophenyl alkenyl ethers and diarylacetylenes has been developed. Diversified tetracyclic-fused dihydroindeno[2,1-b]chromenes bearing a quaternary center were constructed in an efficient, straightforward, atom-economic way with good to excellent yields. The protocol features high bonding efficiency, operational simplicity, broad substrate scope, easy scale-up.

Language: Английский

Synthesis of gem-Difluorinated 2,3-Dihydrobenzofurans Using Freon-22 via [4 + 1] Annulation of Difluorocarbene and Antitumor Activity Evaluation DOI

Qianying Zhou,

Mi Huang, Yongcun Shen

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(6), P. 1212 - 1217

Published: Feb. 1, 2024

As an inexpensive industrial chemical, chlorodifluoromethane (Freon-22), despite its relatively low reactivity, can serve as a practical CF

Language: Английский

Citations

4
Asymmetric Synthesis of Hydrodibenzofurans from Norcaradienes: Kinetic Resolution via [3 + 2] Cycloaddition with Quinones DOI
Siyuan Wang, Lichao Ning, Zhiqiang Li

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(18), P. 3844 - 3849

Published: April 25, 2024

The catalytic asymmetric [3 + 2] cycloaddition of racemic norcaradienes with quinones to construct multicyclic hydrodibenzofurans was achieved by the use chiral N,N′-dioxide/metal complex catalysts. Kinetic resolution accompanied partial racemization occurred, and one enantiomer in prior acted as C2 synthon participate diastereoselective cycloaddition. An enantiodivergent synthesis via a switch metal ions observed when naphthoquinone used partner. DFT calculations revealed profiles processes.

Language: Английский

Citations

2
Au(PPh3)Cl/AgOTf/TsOH-Catalyzed Cascade Reaction between 1-(2-Hydroxyphenyl)-propargyl Alcohols and β-Oxoketones (Amides, Acid): Diastereoselective Construction of cis-3a,8a-Dihydrofuro[2,3-b]benzofuran Framework DOI

Yangyi Zhang,

Guisheng Deng

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

In the Au(PPh

Language: Английский

Citations

2
Catalytic Cycloisomerization–Oxidative Cyclization Reaction Sequence of Enyne Diesters Derived from 2-Propargyloxyarylaldehydes DOI

Karmdeo Prajapati,

Manoj Saini, Rajesh G. Gonnade

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(45), P. 9793 - 9798

Published: Nov. 7, 2024

Enyne diesters derived from 2-propargyloxyarylaldehydes are converted into 2-oxopyranochromenes via In(OTf)

Language: Английский

Citations

0
Synthesis of Tetracyclic-Fused Dihydroindeno[2,1-b]chromenes via Palladium-Catalyzed Alkyne Insertion and C–H Bond Activation DOI
Wenting Guo, Wenting Wu,

X.‐C. WANG

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

An unprecedented Pd-catalyzed cascade alkyne insertion/Heck/C–H activation reaction of o-iodophenyl alkenyl ethers and diarylacetylenes has been developed. Diversified tetracyclic-fused dihydroindeno[2,1-b]chromenes bearing a quaternary center were constructed in an efficient, straightforward, atom-economic way with good to excellent yields. The protocol features high bonding efficiency, operational simplicity, broad substrate scope, easy scale-up.

Language: Английский

Citations

0