Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 9, 2024
A
nickel-catalyzed
intermolecular
three-component
1,1-difunctionalization
of
unactivated
alkenes
with
quinoxaline/naphthoquinone
and
arylboronic
acids
via
organometallic-radical
relay
is
developed.
This
efficient
protocol
provides
a
new
method
to
access
variety
arylalkanes
in
moderate
good
yields
broad
substrate
scope
excellent
functional
group
tolerance.
The
mechanistic
studies
provide
insights
into
the
mechanism
origin
chemo-
regioselectivity
as
well
confirm
generation
functionalized
benzylic
radicals.
Synlett,
Journal Year:
2024,
Volume and Issue:
35(19), P. 2246 - 2250
Published: Aug. 7, 2024
Abstract
A
Fe(OTf)3
and
γ-cyclodextrin-catalyzed
hydroarylation
of
alkenes
with
1-naphthols
or
2-naphthols
is
demonstrated.
This
efficient
general
method
delivers
a
wide
range
benzylic
naphthols
from
readily
available
starting
materials
high
chemo-
regioselectivity
in
up
to
99%
yield,
no
need
for
strong
base
additive.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(45), P. 30733 - 30740
Published: Oct. 29, 2024
Aryl-substituted
aliphatic
amines
are
widely
recognized
as
immensely
valuable
molecules.
Consequently,
the
development
of
practical
strategies
for
construction
these
molecules
becomes
increasingly
urgent
and
critical.
Here,
we
have
successfully
achieved
multifunctionalization
reactions
alkenyl
alcohols
in
a
sequential
relay
process,
which
enables
transformation
patterns
arylamination,
deuterated
methylenated
arylamination
to
easy
access
multifarious
arylalkylamines.
Notably,
novel
functionalization
mode
carbonyl
groups
has
been
developed
facilitate
processes
deuterium
incorporation
methylene
introduction,
thereby
providing
new
means
diverse
transformations
groups.
This
methodology
displays
wide
tolerance
toward
functional
groups,
while
also
exhibiting
good
applicability
across
various
skeletal
structures
alkenols
amines.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 9, 2024
A
nickel-catalyzed
intermolecular
three-component
1,1-difunctionalization
of
unactivated
alkenes
with
quinoxaline/naphthoquinone
and
arylboronic
acids
via
organometallic-radical
relay
is
developed.
This
efficient
protocol
provides
a
new
method
to
access
variety
arylalkanes
in
moderate
good
yields
broad
substrate
scope
excellent
functional
group
tolerance.
The
mechanistic
studies
provide
insights
into
the
mechanism
origin
chemo-
regioselectivity
as
well
confirm
generation
functionalized
benzylic
radicals.
