Synthesis and luminescence of 3-(pyridine-2-yl)-1,2,4-triazine-based Ir(III) complexes DOI Creative Commons
B. S. M. Al-Ghezi, Igor S. Коvalev,

Maria V. Sangalova

et al.

Chimica Techno Acta, Journal Year: 2024, Volume and Issue: 12(1)

Published: Dec. 18, 2024

A series of novel iridium(III) complexes containing 5-N-(aryl)-amino- or 5-cycloamino-3-(pyridine-2-yl)-1,2,4-triazine ligands was obtained. These exhibited red luminescence in solution as well the solid state. Based on DFT studies it suggested that N(2) atom 1,2,4-triazine core is preferable to N(4) one coordination site Ir(III).

Language: Английский

3-(Pyridin-2-yl)-1,2,4-triazine derivatives as promising ligands for iridium(iii) complexes DOI
B. S. M. Al-Ghezi, Igor S. Коvalev, Dmitry S. Kopchuk

et al.

Russian Chemical Bulletin, Journal Year: 2025, Volume and Issue: 74(2), P. 411 - 417

Published: Feb. 1, 2025

Language: Английский

Citations

0
High-Throughput Enabled Iridium-Catalyzed C–H Borylation Platform for Late-Stage Functionalization DOI Creative Commons
Janis M. Zakis,

Rebeka Anna Līpiņa,

Sharon Bell

et al.

ACS Catalysis, Journal Year: 2025, Volume and Issue: 15(4), P. 3525 - 3534

Published: Feb. 12, 2025

In this work, we present a dedicated, high-throughput reaction optimization platform allowing for the rapid evaluation of regiodivergent C–H borylation protocols while minimizing amount starting material required. The workflow was applied to diverse set fragment-like compounds, pharmaceuticals, and agrochemicals, its practicality demonstrated by successfully isolating 36 derivatives bioactive compounds. Leveraging informer library approach, provide comprehensive, side-by-side comparison catalytic methods, revealing insights into strengths, limitations, versatility each protocol. Surprising reactivity patterns, effectiveness ligand-free borylation, utility previously reported directed catalysts outside their expected substrate scope have been noticed. This study highlights potential dedicated platforms expand practical late-stage functionalization pharmaceutical agrochemical research.

Language: Английский

Citations

0
BBr3-Mediated ortho C–H Borylation of Benzamides DOI
Yixuan Liang,

Chengyu Du,

C. Dong

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

We have developed a BBr3-mediated, metal-free ortho C-H borylation of benzamides, enabling the synthesis wide range ortho-borylated benzamides in moderate to good yields. This transformation offers convenient strategy for accessing functionalized which are valuable intermediates pharmaceuticals, agrochemicals, and fine chemical synthesis.

Language: Английский

Citations

0
Repurposing a supramolecular iridium catalyst via secondary Zn⋯OC weak interactions between the ligand and substrate leads to ortho-selective C(sp2)–H borylation of benzamides with unusual kinetics DOI Creative Commons
Jonathan Trouvé,

Vanessa Delahaye,

Michele Tomasini

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(30), P. 11794 - 11806

Published: Jan. 1, 2024

Supramolecular catalysts based on a zinc-porphyrin molecular recognition site and catalytically active iridium enabled the selective ortho -C–H borylation of benzamides under regime in which C–H activation step is not rate-determining.

Language: Английский

Citations

2
Do we really need ligands in Ir-catalyzed C–H borylation? DOI Creative Commons
Janis M. Zakis,

Simone L. Kuhn,

Joanna Wencel‐Delord

et al.

Published: May 29, 2024

Direct borylation of C–H bonds is a privileged strategy to access versatile building blocks and valuable derivatives complex molecules (late-stage functionalization, metabolite synthesis). This perspective aims provide an overview classification the catalytic systems developed in this fast-growing area research. Unexpected selectivity differences between two established directed-borylation have been discovered using high-throughput experimentation highlighting importance classical control experiments catalysis

Language: Английский

Citations

1
Do we really need ligands in Ir-catalyzed C–H borylation? DOI Creative Commons
Janis M. Zakis,

Simone L. Kuhn,

Joanna Wencel‐Delord

et al.

CHIMIA International Journal for Chemistry, Journal Year: 2024, Volume and Issue: 78(7-8), P. 513 - 517

Published: Aug. 21, 2024

Direct borylation of C–H bonds is a privileged strategy to access versatile building blocks and valuable derivatives complex molecules (late-stage functionalization, metabolite synthesis). This perspective aims provide an overview classification the catalytic systems developed in this fast-growing area research. Unexpected selectivity differences between two established directed-borylation have been discovered using high-throughput experimentation highlighting importance classical control experiments catalysis

Language: Английский

Citations

1
Synthesis and luminescence of 3-(pyridine-2-yl)-1,2,4-triazine-based Ir(III) complexes DOI Creative Commons
B. S. M. Al-Ghezi, Igor S. Коvalev,

Maria V. Sangalova

et al.

Chimica Techno Acta, Journal Year: 2024, Volume and Issue: 12(1)

Published: Dec. 18, 2024

A series of novel iridium(III) complexes containing 5-N-(aryl)-amino- or 5-cycloamino-3-(pyridine-2-yl)-1,2,4-triazine ligands was obtained. These exhibited red luminescence in solution as well the solid state. Based on DFT studies it suggested that N(2) atom 1,2,4-triazine core is preferable to N(4) one coordination site Ir(III).

Language: Английский

Citations

0