Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 18, 2024
The
avermectins
make
up
a
biologically
relevant
class
of
complex
natural
products
that
continue
to
inspire
the
development
new
strategies
in
chemical
synthesis.
Herein,
we
disclose
concise
synthesis
southern
core
avermectin
aglycon.
key
hydrobenzofuran
was
forged
by
either
reductive
cyclization
or
cycloisomerization,
both
using
cationic
palladium
precatalyst.
This
hydropalladation
strategy
generated
hydrofuran
ring
under
mild
conditions,
enabling
rapid
construction
tetra-substituted
carbon
stereocenter.
A
Pd-catalyzed,
regio-
and
diastereoselective
cascade
reaction
of
biphenyl
amines
with
1,6-enynes
via
non-rollover
cyclometallation
has
been
described
for
the
synthesis
benzoisoindolinone
derivatives.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 9, 2024
We
report
a
radical
cyano-cyclization
of
1,6-enynes
with
isonitriles
via
photochemically
driven
nickel
catalysis,
forging
alkenyl
nitrile-tethered
γ-lactams
under
mild
conditions.
This
reaction
leverages
the
photoexcitation
Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 18, 2024
The
avermectins
make
up
a
biologically
relevant
class
of
complex
natural
products
that
continue
to
inspire
the
development
new
strategies
in
chemical
synthesis.
Herein,
we
disclose
concise
synthesis
southern
core
avermectin
aglycon.
key
hydrobenzofuran
was
forged
by
either
reductive
cyclization
or
cycloisomerization,
both
using
cationic
palladium
precatalyst.
This
hydropalladation
strategy
generated
hydrofuran
ring
under
mild
conditions,
enabling
rapid
construction
tetra-substituted
carbon
stereocenter.
