Divergent Assembly of Functionalized Pyrazolo[1,5‐a]pyridine Derivatives via [3+2] Cyclization of N‐Aminopyridinium Salts with Various Unsaturated Hydrocarbons DOI
Xiang Liu, Shaohong Ma,

Shi Yan

et al.

Chinese Journal of Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Comprehensive Summary Two reaction modes for metal‐free [3 + 2] cyclization of N ‐aminopyridinium derivatives with β ‐alkoxyvinyl trifluoromethylketones have been described through selective C—O or C—O/C—C bond cleavage. This strategy can also be extended to the enaminones and bromoalkynes. A broad range ‐aminopyridinium, ‐aminoquinolinium, ‐aminoisoquinolinium salts are well tolerated, enabling divergent synthesis trifluoroacylated, non‐substituted, acylated, brominated pyrazolo[1,5‐ a ]pyridine (62 examples).

Language: Английский

Five-Component [2 + 2 + 1 + 1] Tandem Benzannulation Leading to Multifunctionalized Aromatic Amines DOI
Hexiang Wang,

Shuting Li,

Xiaoying Wu

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(45), P. 9648 - 9653

Published: Nov. 1, 2024

An unprecedented five-component [2 + 2 1 1] benzannulation strategy for regioselective assembly of densely functionalized aromatic amines from two ynals, malononitriles, and sodium sulfinates is established. The protocol enables the efficient installation five substituents on a benzene ring via formation multiple chemical bonds in single operation, providing various multifunctionalized primary moderate to good yields. Additionally, three-component [3 cycloaddition NH4SCN was also achieved produce 2-amnopyridine derivatives with serving as an ammonia surrogate.

Language: Английский

Citations

2
Recent Advances on the Construction of Functionalized Indolizine and Imidazo[1,2‐a]pyridine Derivatives DOI
Xiang Liu,

Haifeng Fu,

Qi Hu

et al.

The Chemical Record, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

Abstract Indolizines and imidazo[1,2‐ a ]pyridines are commonly found in natural products, synthetic drugs, bioactive molecules. These two types of derivatives possess good antibacterial, antiparasitic, anticancer activities, so on. The functionalization indolizines has always been hot topic organic chemistry research made significant progress. In recent years, our group dedicated to developing diverse methods for the preparation such important compounds. 1) We have developed C−H reactions efficient modification parent ]pyridines. 2) A variety cycloaddition were established construction indolizine ]pyridine from simple raw materials. 3) intriguing deconstruction‐functionalization indolizines, enabling reorganization heterocyclic frameworks. This paper outlines group's latest advancements constructing structurally derivatives. hope that this work will offer valuable insights inspiration ongoing field N‐heterocyclic

Language: Английский

Citations

1
Divergent Assembly of Functionalized Pyrazolo[1,5‐a]pyridine Derivatives via [3+2] Cyclization of N‐Aminopyridinium Salts with Various Unsaturated Hydrocarbons DOI
Xiang Liu, Shaohong Ma,

Shi Yan

et al.

Chinese Journal of Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Comprehensive Summary Two reaction modes for metal‐free [3 + 2] cyclization of N ‐aminopyridinium derivatives with β ‐alkoxyvinyl trifluoromethylketones have been described through selective C—O or C—O/C—C bond cleavage. This strategy can also be extended to the enaminones and bromoalkynes. A broad range ‐aminopyridinium, ‐aminoquinolinium, ‐aminoisoquinolinium salts are well tolerated, enabling divergent synthesis trifluoroacylated, non‐substituted, acylated, brominated pyrazolo[1,5‐ a ]pyridine (62 examples).

Language: Английский

Citations

0