The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 4, 2024
Here
we
report
a
strategy
that
eliminates
the
need
for
photocatalysts
and
external
additives,
which
provides
an
operable
mild
method
halogen
radical-enabled
dearomatization
of
N-arylpropiolamides
under
oxygen
atmosphere
at
room
temperature.
The
is
applicable
to
wide
range
substrates,
extending
beyond
limited
scope
p-methoxyl
N-phenylpropynamides.
Furthermore,
several
functional
synthetic
intermediates
anticancer
bioactive
molecules
were
successfully
derived
from
3-halogenated
azaspiro[4.5]trienones.
Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 25, 2024
Comprehensive
Summary
3,3‐Disubstituted
oxindoles,
forming
the
core
of
extensive
bioactive
natural
products
and
drugs,
attract
tremendous
efforts
to
develop
efficient
methods
for
their
preparation.
Here,
a
photocatalyst‐free
approach
synthesis
3,3‐disubstituted
oxindoles
via
substrate‐photosensitive
strategy
under
visible
light
was
successfully
developed.
Preliminary
mechanistic
studies
illustrated
that
isatin‐derived
imines
can
be
directly
excited
by
generate
strong
oxidant
states,
facilitating
subsequent
single‐electron
transfer
(SET)
processes
with
Hantzsch
esters
afford
corresponding
α‐amino
radical
intermediates.
Thus,
these
radicals
promote
Giese
addition
or
radical/radical
cross‐coupling
reactions
furnish
diverse
functionalized
3‐substituted
3‐aminooxindoles
in
high
yields.
Rapid Communications in Mass Spectrometry,
Journal Year:
2024,
Volume and Issue:
39(4)
Published: Dec. 2, 2024
ABSTRACT
Rationale
These
experiments
were
conducted
to
measure
the
diversity
of
organo‐U
(IV)
and
U
(III)
ions
created
using
multiple‐stage
tandem
MS
collision‐induced
dissociation
halogen‐substituted
VI
O
2
‐phenide
complexes
[UO
(C
6
H
3
FX)]
+
,
X
=
Cl,
Br,
or
I.
Methods
Samples
UO
(O
C‐C
FX)
prepared
by
digesting
with
appropriate
carboxylic
acids
in
deionized
water.
Solutions
for
ESI
diluting
digested
sample
50:50
O/CH
OH.
Precursor
generated
electrospray
ionization
(ESI).
Multiple‐stage
(He
collision
gas)
a
linear
quadrupole
ion
trap
mass
spectrometer
was
used
prepare
species
such
as
[U
IV
FX(C≡CH)]
III
F(C≡CH)]
subsequent
study
ion‐molecule
reactions
adventitious
neutrals
trap.
Results
CID
I,
caused
removal
both
“yl”
oxo
ligands
from
2+
moiety
create
FX]
.
For
FXC≡CH]
FC≡CH]
products,
hydrolysis
generate
FX
(OH)]
F
concomitant
loss
HC≡CH,
observed.
FBr)]
FI)]
reductive
elimination
respective
halogen
radicals
interesting
C
]
Conclusions
The
use
“preparative”
spectrometry
suite
substituted
benzoic
acid
can
be
remove
group
homologous
studies
intrinsic
reactivity.
The
present
review
focuses
on
recent
progress
(2020–2024)
in
the
visible-light-driven
decarboxylative
cyclization
of
various
carboxylic
acid
derivatives
for
constructing
carbo-/heterocycles.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 4, 2024
Here
we
report
a
strategy
that
eliminates
the
need
for
photocatalysts
and
external
additives,
which
provides
an
operable
mild
method
halogen
radical-enabled
dearomatization
of
N-arylpropiolamides
under
oxygen
atmosphere
at
room
temperature.
The
is
applicable
to
wide
range
substrates,
extending
beyond
limited
scope
p-methoxyl
N-phenylpropynamides.
Furthermore,
several
functional
synthetic
intermediates
anticancer
bioactive
molecules
were
successfully
derived
from
3-halogenated
azaspiro[4.5]trienones.
