Synthesis of 2-Organoselenyl Quinolines via Electro-Oxidative Selenocyclization of Isocyanides

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Organoselenium compounds and quinolines are widely used in drugs materials. Herein, we report an electro-oxidative cyclization between isocyanides diselenides to effectively synthesize 2-organoselenyl a simple undivided cell without transition-metal catalysts or toxic oxidants. Gram-scale synthesis postsynthetic modifications highlighted the practicality of this electrochemical strategy. A series produced with up 82% yield, good functional group tolerance high atom efficiency under room temperature.

Language: Английский

De novo synthesis of 6-6-5 fused-systems through electrochemical decarboxylation and radical domino additions

Green Chemistry, Journal Year: 2024, Volume and Issue: 26(19), P. 10308 - 10313

Published: Jan. 1, 2024

An oxidant and quaternary ammonium salt-free electrosynthesis of 6-6-5 fused systems was developed with excellent atom step economy.

Language: Английский

Regulable selective synthesis of benzofurans and coumarins from aryl propargyl ethers via electrochemical tandem cyclization reaction

Green Chemistry, Journal Year: 2024, Volume and Issue: 26(22), P. 11216 - 11221

Published: Jan. 1, 2024

A divergent protocol for the selective synthesis of benzofuran-2-carboxaldehydes and 3-organoselenyl-2 H -coumarins from propargylic aryl ethers in presence dialkyl(aryl) diselenides under electrochemical reaction conditions was established.

Language: Английский