Brønsted Acid‐Catalyzed Enantioselective and para‐Selective Addition of Phenols to 1‐Alkynylnaphth‐2‐ols DOI Creative Commons
Anjali Dahiya,

Kalyan Dhara,

Jordan Garo

et al.

Advanced Synthesis & Catalysis, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract A chiral Brønsted acid‐catalyzed synthesis of axially alkenes was developed via an enantioselective and para ‐selective Friedel–Crafts reaction between phenols 1‐alkynylnaphth‐2‐ols. This methodology features efficient hydroarylation with high functional group tolerance, complete ‐selectivity, excellent yields (up to 99%), enantioselectivities 94% ee) in the presence a N ‐triflylphosphoramide catalyst. DFT calculations were performed investigate ‐selectivity results indicate that both kinetics thermodynamics parameters are more favorable compared ortho ‐selectivity.

Language: Английский

Brønsted Acid‐Catalyzed Enantioselective and para‐Selective Addition of Phenols to 1‐Alkynylnaphth‐2‐ols DOI Creative Commons
Anjali Dahiya,

Kalyan Dhara,

Jordan Garo

et al.

Advanced Synthesis & Catalysis, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract A chiral Brønsted acid‐catalyzed synthesis of axially alkenes was developed via an enantioselective and para ‐selective Friedel–Crafts reaction between phenols 1‐alkynylnaphth‐2‐ols. This methodology features efficient hydroarylation with high functional group tolerance, complete ‐selectivity, excellent yields (up to 99%), enantioselectivities 94% ee) in the presence a N ‐triflylphosphoramide catalyst. DFT calculations were performed investigate ‐selectivity results indicate that both kinetics thermodynamics parameters are more favorable compared ortho ‐selectivity.

Language: Английский

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