Synthesis of a Natural Product-Based 5H-Thiazolo[5′,4′:5,6]pyrido[2,3-b]indole Derivative via Solid-Phase Synthesis DOI

J. Moon,

Shinae Kim,

Shuanghui Hua

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

The solid-phase synthesis method is optimized for building chemical libraries. Furthermore, libraries are essential tools in drug discovery used to identify hit compounds. We constructed a 5H-thiazolo[5',4':5,6]pyrido[2,3-b]indole derivative library using synthesis. indole insertion reaction at the benzylic position Lewis acid and oxidative cyclization iodine were Using solution-phase conditions, comprising total of eight steps was employed build library. In addition, we found an efficient compound route with each synthetic step having yield 62-82%.

Language: Английский

Synthesis of a Natural Product-Based 5H-Thiazolo[5′,4′:5,6]pyrido[2,3-b]indole Derivative via Solid-Phase Synthesis DOI

J. Moon,

Shinae Kim,

Shuanghui Hua

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

The solid-phase synthesis method is optimized for building chemical libraries. Furthermore, libraries are essential tools in drug discovery used to identify hit compounds. We constructed a 5H-thiazolo[5',4':5,6]pyrido[2,3-b]indole derivative library using synthesis. indole insertion reaction at the benzylic position Lewis acid and oxidative cyclization iodine were Using solution-phase conditions, comprising total of eight steps was employed build library. In addition, we found an efficient compound route with each synthetic step having yield 62-82%.

Language: Английский

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