Copper-Catalyzed Stereoselective Cyanation/Phosphorylation of Formamides with TMSCN and P(O)–H Bonds DOI
Weifeng Xu,

Liyong Fan,

Zikang Li

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 12, 2025

A novel copper-catalyzed approach for the stereoselective cyanation and phosphorylation of formamides has been developed. This protocol enables direct conversion a broad range agents, including H-phosphonates, H-phosphinates, H-phosphine oxides, into target cyanation/phosphorylation products with good to excellent yields. Notably, when optically active H-phosphinates are employed, transformation exhibits exceptional stereoselectivity. In combination DFT calculation systematic step-by-step control experiments, possible reaction mechanism is proposed.

Language: Английский

Copper-Catalyzed Stereoselective Cyanation/Phosphorylation of Formamides with TMSCN and P(O)–H Bonds DOI
Weifeng Xu,

Liyong Fan,

Zikang Li

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 12, 2025

A novel copper-catalyzed approach for the stereoselective cyanation and phosphorylation of formamides has been developed. This protocol enables direct conversion a broad range agents, including H-phosphonates, H-phosphinates, H-phosphine oxides, into target cyanation/phosphorylation products with good to excellent yields. Notably, when optically active H-phosphinates are employed, transformation exhibits exceptional stereoselectivity. In combination DFT calculation systematic step-by-step control experiments, possible reaction mechanism is proposed.

Language: Английский

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