Nanoscale Advances, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Coordination polymer-based systems, particularly Fe(iii)-based polymers, are attracting increasing interest due to their well-controlled morphology, biocompatibility, and versatile surface functionalization. With five unpaired electrons, Fe(iii) offers a promising safer alternative Gd(iii) for MRI applications. While some studies have investigated low molecular weight chelates MRI, the exploration of nanosystems as T 1 probes remains limited. This study focuses on synthesis Fe(iii)/gallic acid nanoparticles functionalized with polyethylene glycol (PEG) shell, designed enhance second-sphere water interaction improve r relaxivity at clinical magnetic fields. The 1H NMR relaxometric properties these were systematically analyzed function proton Larmor frequencies temperature, performance was compared similar system stabilized by polyvinylpyrrolidone (PVP). We aimed determine frequency dependence in coordination assess impact coating modifications contrast efficacy. knowledge is crucial rational design improved nanoprobes, allowing optimized future

Language: Английский