Extracellular matrix: unlocking new avenues in cancer treatment DOI Creative Commons

Jia Lee,

Khuen Yen Ng, Athirah Bakhtiar

et al.

Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: May 27, 2025

Abstract The extracellular matrix (ECM) plays a critical role in cancer progression by influencing tumor growth, invasion, and metastasis. This review explores the emerging therapeutic strategies that target ECM as novel approach treatment. By disrupting structural biochemical interactions within microenvironment, ECM-targeted therapies aim to inhibit overcome resistance. We examine current state of research, focusing on key components such collagen, laminin, fibronectin, periostin, hyaluronic acid, their roles biology. Additionally, we discuss challenges associated with therapies, including drug delivery, specificity, potential side effects, while highlighting recent advancements future directions. underscores ECM-focused enhance efficacy existing treatments contribute more effective therapies.

Language: Английский

Development of an innovative cylindrical carbon nanofiber/gelatin-polycaprolactone hydrogel scaffold for enhanced bone regeneration DOI
Eman Serag, Ahmed Eltawila,

Emad A. Salem

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141250 - 141250

Published: Feb. 1, 2025

Language: Английский

Citations

2
Mechanistic role of stromal cancer-associated fibroblasts in tumorigenesis and brain metastasis: highlighting drug resistance and targeted therapy DOI
Md Rashedunnabi Akanda,

Umme Lubaba,

Md Khalesur Rahman

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155918 - 155918

Published: March 1, 2025

Language: Английский

Citations

1
Multifunctional Light Emitters for Theranostics DOI
Muyideen Olaitan Bamidele, Micheal Bola Bamikale,

Moses Bamidele

et al.

Engineering materials, Journal Year: 2025, Volume and Issue: unknown, P. 297 - 329

Published: Jan. 1, 2025

Language: Английский

Citations

0
Extracellular matrix: unlocking new avenues in cancer treatment DOI Creative Commons

Jia Lee,

Khuen Yen Ng, Athirah Bakhtiar

et al.

Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: May 27, 2025

Abstract The extracellular matrix (ECM) plays a critical role in cancer progression by influencing tumor growth, invasion, and metastasis. This review explores the emerging therapeutic strategies that target ECM as novel approach treatment. By disrupting structural biochemical interactions within microenvironment, ECM-targeted therapies aim to inhibit overcome resistance. We examine current state of research, focusing on key components such collagen, laminin, fibronectin, periostin, hyaluronic acid, their roles biology. Additionally, we discuss challenges associated with therapies, including drug delivery, specificity, potential side effects, while highlighting recent advancements future directions. underscores ECM-focused enhance efficacy existing treatments contribute more effective therapies.

Language: Английский

Citations

0