Beilstein Journal of Nanotechnology,
Journal Year:
2021,
Volume and Issue:
12, P. 1140 - 1150
Published: Oct. 12, 2021
Biomolecules,
such
as
proteins
and
peptides,
can
be
self-assembled.
They
are
widely
distributed,
easy
to
obtain,
biocompatible.
However,
the
self-assembly
of
peptides
has
disadvantages,
difficulty
in
obtaining
high
quantities
materials,
cost,
polydispersity,
purification
limitations.
The
difficulties
using
functional
materials
make
it
more
complicate
arrange
assembled
nanostructures
at
both
microscopic
macroscopic
scales.
Amino
acids,
smallest
constituent
bottom-up
approach,
building
blocks
that
single
amino
acids
advantages
low
synthesis
simple
modeling,
excellent
biocompatibility
biodegradability
vivo.
In
addition,
with
other
components
meet
multiple
scientific
needs.
these
design
attractive
remains
a
challenge
due
simplicity
acids.
Most
review
articles
about
focus
on
large
molecules,
proteins.
preparation
complicated
by
not
yet
been
evaluated.
Therefore,
is
great
significance
systematically
summarize
literature
acid
self-assembly.
This
article
reviews
recent
advances
regarding
self-assembly,
coordination
regulatory
molecule
Small,
Journal Year:
2022,
Volume and Issue:
19(3)
Published: Nov. 28, 2022
Abstract
Functional
nanomaterials
as
nanodrugs
based
on
the
self‐assembly
of
inorganics,
polymers,
and
biomolecules
have
showed
wide
applications
in
biomedicine
tissue
engineering.
Ascribing
to
unique
biological,
chemical,
physical
properties
peptide
molecules,
is
used
an
excellent
precursor
material
for
synthesis
functional
highly
effective
cancer
therapy.
Herein,
recent
progress
design,
synthesis,
regulation,
bioimaging
biotherapy
peptide‐based
summarized.
For
this
aim,
first
molecular
design
controllable
with
0D
3D
structures
are
presented,
then
customization
strategies
presented.
Then,
bioimaging,
chemotherapy,
photothermal
therapy
(PTT),
photodynamic
(PDT)
demonstrated
discussed
detail.
Furthermore,
drugs
preclinical,
clinical
trials,
approved
briefly
described.
Finally,
challenges
potential
solutions
pointed
out
addressing
questions
promising
research
topic.
This
comprehensive
review
can
guide
motif
regulation
facile
nanodrugs,
further
promote
their
practical
diagnostics
diseases.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(5), P. 4813 - 4833
Published: Feb. 20, 2023
High
potency
and
safe
therapies
are
still
required
for
ischemic
stroke,
which
is
a
leading
cause
of
global
death
disability.
Herein,
reactive
oxygen
species
(ROS)-responsive,
transformable,
triple-targeting
dl-3-n-butylphthalide
(NBP)
nanotherapy
was
developed
stroke.
To
this
end,
ROS-responsive
nanovehicle
(OCN)
first
constructed
using
cyclodextrin-derived
material,
showed
considerably
enhanced
cellular
uptake
in
brain
endothelial
cells
due
to
notably
reduced
particle
size,
morphological
transformation,
surface
chemistry
switching
upon
triggering
via
pathological
signals.
Compared
nonresponsive
nanovehicle,
transformable
nanoplatform
OCN
exhibited
significantly
higher
accumulation
mouse
model
thereby
affording
potentiated
therapeutic
effects
the
derived
from
NBP-containing
OCN.
For
decorated
with
stroke-homing
peptide
(SHp),
we
found
increased
transferrin
receptor-mediated
endocytosis,
addition
previously
recognized
targeting
capability
activated
neurons.
Consistently,
engineered
nanoplatform,
i.e.,
SHp-decorated
(SON),
displayed
more
efficient
distribution
injured
mice
showing
considerable
localization
Furthermore,
finally
formulated
(NBP-loaded
SON)
demonstrated
highly
potent
neuroprotective
activity
mice,
outperformed
SHp-deficient
at
5-fold
dose.
Mechanistically,
our
bioresponsive,
attenuated
ischemia/reperfusion-induced
permeability
improved
dendritic
remodeling
synaptic
plasticity
neurons
tissue,
promoting
much
better
functional
recovery,
were
achieved
by
efficiently
enhancing
NBP
delivery
neurons/microglial
cells,
normalizing
microenvironment.
Moreover,
preliminary
studies
indicated
that
good
safety
profile.
Consequently,
desirable
efficiency,
spatiotemporally
controlled
drug
release
performance,
high
translational
potential
holds
great
promise
precision
therapy
stroke
other
diseases.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2023,
Volume and Issue:
11
Published: March 2, 2023
Natural
polymers
have
been
widely
used
in
scaffolds
for
tissue
engineering
due
to
their
superior
biocompatibility,
biodegradability,
and
low
cytotoxicity
compared
synthetic
polymers.
Despite
these
advantages,
there
remain
drawbacks
such
as
unsatisfying
mechanical
properties
or
processability,
which
hinder
natural
substitution.
Several
non-covalent
covalent
crosslinking
methods
induced
by
chemicals,
temperatures,
pH,
light
sources
suggested
overcome
limitations.
Among
them,
light-assisted
has
considered
a
promising
strategy
fabricating
microstructures
of
scaffolds.
This
is
the
merits
non-invasiveness,
relatively
high
efficiency
via
penetration,
easily
controllable
parameters,
including
intensity
exposure
time.
review
focuses
on
photo-reactive
moieties
reaction
mechanisms,
are
exploited
along
with
polymer
its
applications.
Journal of Peptide Science,
Journal Year:
2025,
Volume and Issue:
31(3)
Published: Feb. 4, 2025
ABSTRACT
Peptides
binding
overexpressed
breast
and
cervical
cancer
cell
surface
proteins
can
be
isolated
by
phage
display
technology,
their
affinity
to
potential
receptors
assessed
molecular
docking.
We
44
clones
displaying
dodecapeptides
with
high
HeLa
MDA‐MB‐231
(MDA)
cells
repeated
biopanning
of
an
MK13
library
explored
specific
Six
peptides
appeared
repeatedly
during
biopanning:
two
(H5/H21),
four
MDA
(M3/M7/M15/M17).
Peptide
pairs
M3/H5
H1/M17
had
both
lines.
A
systematic
review
identified
Annexin
A2,
EGFR,
CD44,
CD146,
Integrin
alpha
V
as
protein
targets
in
cells,
Vimentin,
Galectin‐1,
Annexins
A1
A5
cells.
Via
virtual
screening,
we
selected
six
the
highest
total
docking
scores:
H1
(−916.32),
H6
(−979.21),
H19
(−1093.24),
M6
(−732.21),
M16
(−745.5),
M19
(−739.64),
that
scores
were
strengthened
type,
interacting
amino
acid
side
chains,
polarity
peptides.
This
approach
facilitates
selection
relevant
could
further
for
active
targeting
diagnosis
treatment.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Nov. 21, 2024
Phase-separating
peptides
(PSPs)
self-assembling
into
coacervate
microdroplets
(CMs)
are
a
promising
class
of
intracellular
delivery
vehicles
that
can
release
macromolecular
modalities
deployed
in
wide
range
therapeutic
treatments.
However,
the
molecular
grammar
governing
uptake
and
kinetics
CMs
remains
elusive.
Here,
we
systematically
manipulate
sequence
PSPs
to
unravel
relationships
between
their
structure,
physical
properties
resulting
CMs,
efficacy.
We
show
few
amino
acid
alterations
sufficient
modulate
viscoelastic
towards
either
gel-like
or
liquid-like
state
as
well
binding
interaction
with
cellular
membranes,
collectively
enabling
tune
cargo
release.
also
demonstrate
optimized
display
excellent
transfection
efficiency
hard-to-transfect
cells
such
primary
fibroblasts
immune
cells.
Our
findings
provide
guidelines
precisely
program
material
PSP
achieve
tunable
depending
on
modality,
broad
implications
for
applications
protein,
gene,
cell
therapies.
peptide
(PSP)
have
emerged
vectors,
but
is
authors
establish
designing
optimizing
CM-based
systems.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 23, 2025
Abstract
The
development
of
autonomous
bioelectronic
devices
capable
dynamically
adapting
to
changing
biological
environments
represents
a
significant
advancement
in
healthcare
and
wearable
technologies.
Such
systems
draw
inspiration
from
the
precision,
adaptability,
self‐regulation
processes,
requiring
materials
with
intrinsic
versatility
seamless
bio‐integration
ensure
biocompatibility
functionality
over
time.
Silk
fibroin
(SF)
derived
Bombyx
mori
cocoons,
has
emerged
as
an
ideal
biomaterial
unique
combination
biocompatibility,
mechanical
flexibility,
tunable
biodegradability.
Adding
features
into
SF,
including
self‐healing,
shape‐morphing,
controllable
degradation,
enables
dynamic
interactions
living
tissues
while
minimizing
immune
responses
mismatches.
Additionally,
structural
tunability
environmental
sustainability
SF
further
reinforce
its
potential
platform
for
adaptive
implants,
epidermal
electronics,
intelligent
textiles.
This
review
explores
recent
progress
understanding
structure–property
relationships
modification
strategies,
great
integration
advanced
addressing
challenges
related
scalability,
reproducibility,
multifunctionality.
Future
opportunities,
such
AI‐assisted
material
design,
scalable
fabrication
techniques,
incorporation
wireless
personalized
technologies,
are
also
discussed,
positioning
key
bridging
gap
between
artificial
Nano Letters,
Journal Year:
2019,
Volume and Issue:
19(6), P. 3730 - 3736
Published: April 30, 2019
We
demonstrate
the
2-D
anisotropic
formation
of
ultrathin
free-floating
Pt
nanoplates
from
assembly
small
nanocrystals
using
T7
peptide
(Ac-TLTTLTN-CONH2).
As-formed
are
rich
in
grain
boundaries
that
can
promote
their
catalytic
activities.
Furthermore,
we
a
minor
number
Pd
atoms
selectively
deposit
on
and
stabilize
boundaries,
which
leads
to
enhanced
structure
stability.
The
Pd-enhanced
polycrystal
show
great
oxygen
reduction
reaction
activities
with
15.5
times
higher
specific
activity
13.7
mass
than
current
state-of-the-art
commercial
Pt/C
electrocatalysts
as
well
2.5
for
hydrogen
evolution
compared
Pt/C.
Advanced Healthcare Materials,
Journal Year:
2021,
Volume and Issue:
11(2)
Published: Nov. 8, 2021
Tremendous
advances
have
been
made
toward
accurate
recapitulation
of
the
human
intestinal
system
in
vitro
to
understand
its
developmental
process,
and
disease
progression.
However,
current
models
are
often
confined
2D
or
2.5D
microarchitectures,
which
is
difficult
mimic
systemic
level
complexity
native
tissue.
To
overcome
this
problem,
physiologically
relevant
developed
with
a
3D
hollow
tubular
structure
using
bioprinting
strategy.
A
tissue-specific
biomaterial,
colon-derived
decellularized
extracellular
matrix
(Colon
dECM)
it
provides
significant
maturation-guiding
potential
cells.
fabricate
perfusable
model,
simultaneous
printing
process
multiple
materials
through
concentrically
assembled
nozzles
light-activated
Colon
dECM
bioink
employed
by
supplementing
ruthenium/sodium
persulfate
as
photoinitiator.
The
bioprinted
tissue
show
spontaneous
morphogenesis
epithelium
without
any
external
stimuli.
In
consequence,
printed
cells
form
multicellular
aggregates
cysts
then
differentiate
into
several
types
enterocytes,
building
junctional
networks.
This
can
serve
platform
evaluate
effects
drug-induced
toxicity
on
create
coculture
model
commensal
microbes
immune
for
future
therapeutics.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(45), P. 5790 - 5803
Published: Jan. 1, 2024
Large-pore
protein
crystals
(LPCs)
are
an
emerging
class
of
biomaterials.
The
inherent
diversity
proteins
translates
to
a
crystal
lattice
structures,
many
which
display
large
pores
and
solvent
channels.
These
can,
in
turn,
be
functionalized
