Self‐Assembling Peptide‐Based Hydrogels for Wound Tissue Repair

Advanced Science, Journal Year: 2022, Volume and Issue: 9(10)

Published: Feb. 9, 2022

Wound healing is a long-term, multistage biological process that includes hemostasis, inflammation, proliferation, and tissue remodeling requires intelligent designs to provide comprehensive convenient treatment. The complexity of wounds has led lack adequate wound treatment materials, which must systematically regulate unique microenvironments. Hydrogels have significant advantages in due their ability spatiotemporal control over the process. Self-assembling peptide-based hydrogels are particularly attractive innate biocompatibility biodegradability along with additional including ligand-receptor recognition, stimulus-responsive self-assembly, mimic extracellular matrix. materials self-assemble response physiological environment, resulting functionalized microscopic structures, makes them conducive This review introduces several self-assembling systems various emphasizes recent advances allow for precise during different stages healing. Moreover, development multifunctional can remodel immune microenvironment therapy also been summarized. Overall, this sheds light on future clinical practical applications hydrogels.

Language: Английский

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Naturally sourced hydrogels: emerging fundamental materials for next-generation healthcare sensing

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(9), P. 2992 - 3034

Published: Jan. 1, 2023

The flourishing development of flexible healthcare sensing systems is inseparable from the fundamental materials with application-oriented mechanical and electrical properties. Thanks to continuous inspiration our Mother Nature, hydrogels originating natural biomass are attracting growing attention for their structural functional designs owing unique chemical, physical biological These highly efficient architectural enable them be most promising candidates electronic devices. This comprehensive review focuses on recent advances in naturally sourced constructing multi-functional sensors applications thereof. We first briefly introduce representative polymers, including polysaccharides, proteins, polypeptides, summarize physicochemical design principles fabrication strategies hydrogel based these polymers outlined after material properties required presented. then highlight various techniques devices, illustrate examples wearable or implantable bioelectronics pressure, strain, temperature, biomarker field systems. Finally, concluding remarks challenges prospects hydrogel-based provided. hope that this will provide valuable information next-generation build a bridge between as matter an applied target accelerate new near future.

Language: Английский

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Magnesium‐Encapsulated Injectable Hydrogel and 3D‐Engineered Polycaprolactone Conduit Facilitate Peripheral Nerve Regeneration

Advanced Science, Journal Year: 2022, Volume and Issue: 9(21)

Published: June 2, 2022

Peripheral nerve injury is a challenging orthopedic condition that can be treated by autograft transplantation, gold standard treatment in the current clinical setting. Nevertheless, limited availability of autografts and potential morbidities donors hampers its widespread application. Bioactive scaffold-based tissue engineering promising strategy to promote regeneration. Additionally, magnesium (Mg) ions enhance regeneration; however, an effectively controlled delivery vehicle necessary optimize their vivo therapeutic effects. Herein, bisphosphonate-based injectable hydrogel exhibiting sustained Mg

Language: Английский

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Design the molecule structures to achieve functional advantages of hydrogel wound dressings: Advances and strategies

Composites Part B Engineering, Journal Year: 2022, Volume and Issue: 247, P. 110313 - 110313

Published: Oct. 4, 2022

Language: Английский

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Molecularly Stimuli-Responsive Self-Assembled Peptide Nanoparticles for Targeted Imaging and Therapy

ACS Nano, Journal Year: 2023, Volume and Issue: 17(9), P. 8004 - 8025

Published: April 20, 2023

Self-assembly has emerged as an extensively used method for constructing biomaterials with sizes ranging from nanometers to micrometers. Peptides have been investigated self-assembly. They are widely applied owing their desirable biocompatibility, biodegradability, and tunable architecture. The development of peptide-based nanoparticles often requires complex synthetic processes involving chemical modification supramolecular Stimuli-responsive peptide nanoparticles, also termed "smart" capable conformational changes in response stimuli, a class promising materials. These smart find diverse range biomedical applications, including drug delivery, diagnostics, biosensors. systems include external stimuli (such light, temperature, ultrasound, magnetic fields) internal pH, redox environment, salt concentration, biomarkers), facilitating the generation library self-assembled imaging therapy. Thus, this review, we mainly focus on built by self-assembly strategy systematically discuss mechanisms various stimuli. Furthermore, summarize applications nanomaterials, diagnosis therapy, demonstrate potential medical translation.

Language: Английский

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Recent advances in biopolymer-based hydrogels and their potential biomedical applications

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 323, P. 121408 - 121408

Published: Sept. 17, 2023

Language: Английский

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Immunomodulatory Hydrogels: Advanced Regenerative Tools for Diabetic Foot Ulcer

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(10)

Published: Jan. 1, 2023

Abstract Diabetic foot ulcer (DFU) is one of the most common complications diabetes, bringing physical and mental challenges for patients due to lack efficient curative therapy. Despite considerable advances in pharmacological surgical approaches, clinical trials DFU remain disappointing local overactive excessive inflammation. Immunomodulatory hydrogels has significant advantages overcome challenge DFUs Here, recent fabrication regenerative utilization functional altering immune microenvironment are comprehensively reviewed. The pathological features healing processes DFUs, followed by summarizing physicochemical properties essential design immunomodulation briefly introduced. Then, potential immuno‐therapeutic modalities emerging trends used treat via multitherapeutic approaches enhanced efficacy safety discussed. Taken together, linking structural their functions therapy with a particular focus on immunomodulatory stimuli, this review can promote further designing advanced resulting improved diabetic wound repair through translation into setting near future.

Language: Английский

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Perspectives on recent advancements in energy harvesting, sensing and bio-medical applications of piezoelectric gels

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(17), P. 6191 - 6220

Published: Jan. 1, 2023

This review highlights the recent progress in piezoelectric gels (also known as PiezoGels) comprised of polymers, ceramic oxides and supramolecular materials used for energy harvesting, sensing wound dressing.

Language: Английский

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Hydrogel-Functionalized Bandages with Janus Wettability for Efficient Unidirectional Drug Delivery and Wound Care

ACS Nano, Journal Year: 2024, Volume and Issue: 18(4), P. 3468 - 3479

Published: Jan. 16, 2024

Chronic wounds have imposed a severe physical and economic burden on the global healthcare system, which are usually treated by delivery of drugs or bioactive molecules to wound bed through dressings. In this work, we demonstrated hydrogel-functionalized bandage with Janus wettability in bilayer structure achieve unidirectional drug multifunctional care. The patterned porous gradient wetting channels upper layer is responsible for transport from outside (up 90% efficiency) while preventing diffusion unwanted directions (<8%). hydrogel composed chitosan quaternary ammonium salt (HACC), poly(vinyl alcohol) (PVA), poly(acrylic acid) (PAA) at bottom further functionalized such biocompatibility, excellent antibacterial properties, hemostatic ability promote healing. Especially, exhibits mechanical flexibility (∼198% strain), can comply well skin deformation (stretching, bending, twisting) maintain behavior without any leakage. vivo full-thickness model confirms that significantly facilitate epithelialization collagen deposition improve efficiency, thus promoting closure healing (the ratio was 98.10% day 15). Such synergistic strategy care provides more efficient, economical, direct method healing, could be used as potential high-performance dressing clinical application.

Language: Английский

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Biomimetic peptide dynamic hydrogel inspired by humanized defensin nanonets as the wound-healing gel coating

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 470, P. 144266 - 144266

Published: June 20, 2023

Clinical treatment of chronic wounds, particularly those prone to relapse, has been hampered by the regeneration, infection complications, and malignant transformation disordered tissue adhesions. At surface intestinal endothelial, human defensins self-assemble into higher-order nanonets that defend host cells, fight inflammation promote wound healing. Inspired this antimicrobial nanostructured network, we herein attempted construct an nanonet with hemostatic function integrated as dressing. Aiding molecular docking dynamics analysis, designed a nanogel called ACFP, which was constructed spontaneously assembling two RADA16-based hydrogelators one θ-defensin-derived peptide motif. As expected, ACFP possesses properties derived from structure defensin, well ability prevent bleeding effectively injectable biocompatible hydrogel, successfully treated epidermal wounds associated multiple bacterial infections, promoted healing complicated intraperitoneal involving cecum adjacent abdominal walls while preventing adhesion. In addition providing comprehensive therapeutic approach tremendous clinical potential for therapy, may encourage development biomimetic hydrogels functions against wide range diseases.

Language: Английский

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