Small,
Journal Year:
2023,
Volume and Issue:
19(49)
Published: Aug. 27, 2023
Alzheimer's
disease
(AD)
is
a
severe
neurodegenerative
condition
characterized
by
inflammation,
beta-amyloid
(Aβ)
plaques,
and
neurodegeneration,
which
currently
lack
effective
treatments.
Chiral
nanomaterials
have
emerged
as
promising
option
for
treating
disorders
due
to
their
high
biocompatibility,
strong
sustained
release
ability,
specific
enantiomer
selectivity.
The
development
of
stimulus-responsive
chiral
nanomaterial,
UiO-66-NH2
@l-MoS2
QDs@PA-Ni
(MSP-U),
the
treatment
AD
reported.
MSP-U
found
stimulate
neural
stem
cell
(NSCs)
differentiation,
promote
in
situ
hydrogen
(H2
)
production,
clear
Aβ
plaques.
l-MoS2
QDs
modified
with
l-Cysteine
(l-Cys)
effectively
enhance
differentiation
NSCs
into
neurons
through
circularly
polarized
near-infrared
radiation.
Doped-phytic
acid
nickel
(PA-Ni)
improves
activity
scavenging
reactive
oxygen
species
at
lesion
site
via
photocatalytic
H2
production.
Loading
UiO-66
type
metal
oxide
suppresses
electron-hole
recombination
effect,
thereby
achieving
rapid
charge
separation
improving
transport
photogenerated
electrons,
leading
significantly
improved
production
efficiency.
photothermal
effect
also
clears
generated
In
vivo
evaluations
show
that
spatial
cognition
memory,
suggesting
potential
candidate
using
nanomaterials.
Self-sorting
by
supramolecular
assembly
involving
homochiral
building
blocks
is
of
vital
importance
in
life
systems,
which
allows
the
coexistence
multiple
species
an
orthogonal
complex
mixture
to
achieve
respective
biological
functions
simultaneously.
However,
self-sorting
chiral
molecules,
typically
remains
a
challenge
artificial
limiting
function
development
materials.
Herein,
we
report
self-sorted
hydrogel
network
formed
two
l-phenylalanine
derivatives,
LPPF
and
LPFA,
independently
self-assemble
into
nanofibers
with
distinct
helical
orientations
diameters.
Compared
single-component
this
fibrous
exhibits
superior
cell
adhesion
proliferation
capability
due
promoted
fibronectin
adsorption.
Furthermore,
demonstrates
strong
potential
for
promoting
chondrogenic
differentiation,
as
evidenced
up-regulated
expression
cartilage-specific
markers
(SOX9,
ACAN,
COL2)
vitro.
In
mouse
models
osteoarthritis,
+
LPFA
significantly
improves
cartilage
repair,
enhances
subchondral
bone
structure,
reduces
osteophyte
formation.
These
findings
establish
hydrogels
promising
approach
osteoarthritis
treatment,
holds
great
utilization
field
regenerative
medicine.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: March 11, 2025
Helicoid
metal
nanoparticles
with
intrinsic
chirality
have
unveiled
tailorable
properties
and
unlocked
many
chirality-related
applications
across
various
fields.
Nevertheless,
the
existing
strategies
for
enantioselective
synthesis
of
helicoid
been
predominantly
limited
to
gold.
Here,
we
demonstrate
a
robust
versatile
strategy
beyond
gold,
leveraging
chiral
nanoconfinement
provided
by
SiO2
or
nanoshells.
The
enables
decoupling
ligand-directed
crystal
growth
from
induction,
allowing
independent
tuning
these
two
critical
aspects.
As
result,
this
approach
can
not
only
facilitate
replication
shapes
nanoshells
but
also
allow
generation
alternative
shapes.
By
employing
approach,
Pt,
Au@Pt,
Au@Pd,
Au@Ag,
Au@Cu
nanoparticles.
chiroplasmonic
Pt-
Pd-based
discovered,
inversion
Ag-based
via
facet
control
has
documented
theoretically
explained.
enriches
toolbox
creating
supports
their
exploration
in
diverse
applications.
Strategies
were
mainly
authors
present
helicoidal
gold
using
silica
shells.
Small,
Journal Year:
2023,
Volume and Issue:
19(49)
Published: Aug. 27, 2023
Alzheimer's
disease
(AD)
is
a
severe
neurodegenerative
condition
characterized
by
inflammation,
beta-amyloid
(Aβ)
plaques,
and
neurodegeneration,
which
currently
lack
effective
treatments.
Chiral
nanomaterials
have
emerged
as
promising
option
for
treating
disorders
due
to
their
high
biocompatibility,
strong
sustained
release
ability,
specific
enantiomer
selectivity.
The
development
of
stimulus-responsive
chiral
nanomaterial,
UiO-66-NH2
@l-MoS2
QDs@PA-Ni
(MSP-U),
the
treatment
AD
reported.
MSP-U
found
stimulate
neural
stem
cell
(NSCs)
differentiation,
promote
in
situ
hydrogen
(H2
)
production,
clear
Aβ
plaques.
l-MoS2
QDs
modified
with
l-Cysteine
(l-Cys)
effectively
enhance
differentiation
NSCs
into
neurons
through
circularly
polarized
near-infrared
radiation.
Doped-phytic
acid
nickel
(PA-Ni)
improves
activity
scavenging
reactive
oxygen
species
at
lesion
site
via
photocatalytic
H2
production.
Loading
UiO-66
type
metal
oxide
suppresses
electron-hole
recombination
effect,
thereby
achieving
rapid
charge
separation
improving
transport
photogenerated
electrons,
leading
significantly
improved
production
efficiency.
photothermal
effect
also
clears
generated
In
vivo
evaluations
show
that
spatial
cognition
memory,
suggesting
potential
candidate
using
nanomaterials.
