International Immunopharmacology, Journal Year: 2024, Volume and Issue: 130, P. 111695 - 111695
Published: Feb. 23, 2024
Language: Английский
Obesity, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 4, 2025
Abstract Objective Both alternate‐day fasting (ADF) and calorie restriction (CR) are effective weight loss strategies. However, most individuals find it difficult to adhere CR. Furthermore, CR can induce an excessive of not only fat but also muscle mass. This study aimed compare the effects ADF pair‐feeding (PF) on metabolic pathways underlying obesity in mice with high‐fat diet (HFD)‐induced obesity. Methods Male C57BL/6N Tac ( n = 10 per group) were fed HFD for 8 weeks establish a diet‐induced model. Mice then continued either access food or PF next weeks. We measured body weight, adiposity, plasma biomarkers, molecular mechanisms involving lipolysis autophagy. Results resulted comparable loss. Compared PF, showed significant reduction liver hepatic triglyceride levels. significantly increased ketone levels white adipose tissue lipolysis. tended activate autophagy elongation autophagosome formation, which insignificant. Conclusions These findings indicated that is promising intervention diseases, potentially due its superior efficacy promoting ketogenesis compared PF.
Language: Английский
Citations
0
Poultry Science, Journal Year: 2025, Volume and Issue: 104(4), P. 104941 - 104941
Published: Feb. 22, 2025
Language: Английский
Citations
0
Metabolites, Journal Year: 2025, Volume and Issue: 15(3), P. 150 - 150
Published: Feb. 23, 2025
Metabolic syndrome (MetS) is an association of risk factors that share insulin resistance (IR), exerting a super cumulative effect on the developing cardiometabolic diseases. Lifestyle optimization key element in prevention and non-pharmacological therapy MetS. Certain studies have concluded some dietary patterns could be more beneficial as adjunctive treatment for Fasting mimicking diet (FMD) form periodic fasting which caloric intake restricted 5 days each month. It has been studied its effects not only patients with neoplasia neurodegenerative diseases but also IR metabolism. In this narrative review, FMD MetS were analyzed, focusing impact metabolic components summarizing findings from human studies. demonstrated by reducing BMI waist circumference, preserving lean mass, improving profile. Moreover, individuals higher or greater number appear to derive benefits intervention. However, limitations such high dropout rates, small sample sizes, methodological constraints restrict generalizability current findings. Further large-scale are needed confirm these establish viable strategy managing
Language: Английский
Citations
0
Cell Metabolism, Journal Year: 2025, Volume and Issue: 37(3), P. 561 - 563
Published: March 1, 2025
Language: Английский
Citations
0
Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 866 - 866
Published: March 3, 2025
Breast cancer therapies have dramatically improved survival rates, but their long-term effects, especially on aging survivors, need careful consideration. This review delves into how breast treatments and intersect, focusing the epigenetic changes triggered by chemotherapy, radiation, hormonal treatments, targeted therapies. Treatments can speed up biological altering DNA methylation, histone modifications, chromatin remodeling, affecting gene expression without changing sequence itself. The explains double-edged sword effect of therapy-induced which help fight also accelerate aging. Chemotherapy therapies, in particular, impact methylation promoting chronic inflammation shortening telomeres. These increase age, as seen clocks biomarkers like p21, play roles drug resistance therapeutic decisions. Chronic inflammation, driven higher levels inflammatory cytokines such TNF-α IL-6 well telomere shortening, significantly contributes to characteristics survivors. Non-coding RNAs, including microRNAs long non-coding are crucial regulating pathways altered these treatments. explores new targeting changes, inhibitors, deacetylase microRNA-based reduce effects therapy. Non-drug approaches, dietary lifestyle show promise combating It highlights clinical signs aging-related side heart lung problems, endocrine reproductive issues, reduced quality life. development comprehensive methods CHEMO-RADIAT score predict major cardiovascular events after therapy is discussed. Understanding caused offers valuable insights for creating interventions enhance health span life Continued research fully understand alterations impacts.
Language: Английский
Citations
0
Food & Function, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Diabetic Kidney Disease (DKD) is a common and serious complication of diabetes, particularly Type 2 Diabetes Mellitus (T2DM), which significantly contributes to patient morbidity mortality. The limitations traditional treatments like ACE inhibitors ARBs in managing DKD progression highlight the need for innovative therapeutic strategies. This review examines impact various dietary patterns, such as Mediterranean diet, ketogenic intermittent fasting, DASH vegetarian on management DKD. Evidence suggests these diets can halt DKD, although further research needed confirm their long-term effectiveness safety. Personalized approaches tailored individual needs may enhance outcomes patients.
Language: Английский
Citations
0
IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown
Published: March 19, 2025
Language: Английский
Citations
0
Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)
Published: April 9, 2025
The global prevalence of diabetes is rapidly increasing, significantly raising the risk various cardiovascular diseases. Among these, diabetic cardiomyopathy (DCM) a distinct and critical complication characterized by ventricular hypertrophy impaired myocardial contractility, ultimately progressing to heart failure making it leading cause mortality among patients. Despite advances in pharmacological therapies, effectiveness managing cardiac dysfunction DCM remains challenging. Consequently, exploring additional therapeutic strategies for prevention treatment urgently needed. Beyond approaches, lifestyle modifications, particularly exercise dietary interventions, play fundamental role due their significant benefits This review synthesizes recent advancements field, elucidating underlying mechanisms through which interventions influence pathophysiology. By integrating these strategies, we aim facilitate development personalized regimens that effectively mitigate or prevent progression.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: April 22, 2025
High-intensity interval training (HIIT) and time-restricted feeding (TRF) have shown promise for improving glucose regulation by increasing insulin sensitivity, enhancing uptake, reducing production. Therefore, this study investigates the combined effects of HIIT TRF on AKT/FOXO1/PEPCK signaling pathway in liver tissue type 2 diabetic rats. 42 male Wistar rats (4-5 weeks age) were included study. The animals randomly divided into two groups: (1) Standard diet (SD, non-Diabetic (Non-D, n = 7) (2) High-fat (HFD, 35) 4 weeks. To induce diabetes, 35 mg/kg streptozotocin (STZ) was injected intraperitoneally (IP). Animals with blood levels > 250 mg/dL considered as diabetic. Diabetic 5 groups (n 7): Diabetes-exercise (D-EX), Diabetes-TRF (D-TRF), (3) Diabetes-combined exercise (D-TRF&EX), (4) Diabetes no treatment (D-NT), (5) metformin (D-MET). Interventions (HIIT TRF) performed 10 Rats Non-D group did not receive or TRF. Periodic Acid-Schiff (PAS) staining used to histologically analyze tissue. Levels glucose, resistance (IR), FOXO1 protein, PEPCK, area under curve (AUC) following IPGTT test, significantly decreased compared D-NT (p < 0.05). AKT protein 0.01), glycogen content 0.05), sensitivity 0.001) increased group. Microscopic examination general showed a better arrangement both than Combining may be effective regulation, interventions alone.
Language: Английский
Citations
0
Technology in Cancer Research & Treatment, Journal Year: 2024, Volume and Issue: 23
Published: Jan. 1, 2024
Treatment of triple-negative breast cancer (TNBC) remains challenging. Intermittent fasting (IF) has emerged as a promising approach to improve metabolic health various disorders. Clinical studies indicate IF is essential for TNBC progression. However, the molecular mechanisms underlying remodeling in regulating and progression are still unclear.
Language: Английский
Citations
3