Langmuir,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 10, 2025
Understanding
and
controlling
the
surface
properties
of
bioscaffolds
are
crucial
for
regulating
cell
adhesion
proliferation
behaviors.
We
here
focused
on
poly(vinylidene
fluoride)
(PVDF),
in
which
polymer
chains
oriented
through
poling
treatment
to
form
a
polar
β-form
crystal.
The
aggregation
states
uniaxially
stretched
PVDF
films
subjected
were
investigated
based
water
contact
angle
measurements
sum-frequency
generation
spectroscopy.
During
under
sufficiently
strong
electric
field,
dipole
moments
crystals,
inherently
aligned
within
each
crystalline
domain,
become
more
uniformly
across
entire
film.
As
result,
resists
structural
reorganization
even
upon
exposure
water.
This
stable
surface,
maintains
its
despite
environmental
changes,
was
found
promote
proliferation,
as
well
protein
adsorption.
Our
findings
contribute
deeper
understanding
relationship
between
scaffold
surfaces
interactions,
ultimately
advancing
insights
into
Mechanobiology in Medicine,
Journal Year:
2024,
Volume and Issue:
2(3), P. 100079 - 100079
Published: May 16, 2024
Mechanical
stimuli
are
known
to
play
critical
roles
in
mediating
tissue
repair
and
regeneration.
Recently,
this
knowledge
has
led
a
paradigm
shift
toward
proactive
programming
of
biological
functionalities
biomaterials
by
leveraging
mechanics–geometry–biofunction
relationships,
which
beginning
shape
the
newly
emerging
field
mechanobiomaterials.
To
profile
field,
article
aims
elucidate
fundamental
principles
modulating
responses
with
material–tissue
mechanical
interactions,
illustrate
recent
findings
on
relationships
between
material
properties
responses,
discuss
importance
mathematical/physical
models
numerical
simulations
optimizing
geometry,
outline
design
strategies
for
mechanobiomaterials
their
potential
Given
that
is
still
its
infancy,
also
discusses
open
questions
challenges
need
be
addressed.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 1, 2024
The
development
of
next
generation
soft
and
recyclable
materials
prominently
features
dynamic
(reversible)
chemistries
such
as
host-guest,
supramolecular,
covalent.
Dynamic
systems
enable
injectability,
reprocessability,
time-dependent
mechanical
properties.
These
properties
arise
from
the
inherent
relationship
between
rate
equilibrium
constants
(RECs)
molecular
junctions
(cross-links)
resulting
macroscopic
behavior
networks.
However,
few
examples
explicitly
measure
RECs
while
exploring
this
connection
material
properties,
particularly
for
polymeric
hydrogel
systems.
Here
we
use
covalent
imine
formation
to
study
how
single-point
compositional
changes
in
NH
Emergent Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 14, 2025
Abstract
The
combined
use
of
Low
Frequency-Pulsed
Electromagnetic
Field
(LF-PEMF)
and
magnetic
nanoparticles
(MNPs)
represents
an
innovative
approach
for
biomedical
applications
in
recent
years.
Also,
the
surface
properties
MNPs
play
a
crucial
role
understanding
how
they
will
interact
with
biological
systems
determining
their
suitability
intended
applications.
aim
this
study
was
to
evaluate
interactions
different
charges
adipose-derived
mesenchymal
stem
cells
(AD-MSCs)
under
LF-PEMF
stimulation.
Intracellular
localization
vitro
cytotoxicity
surface-modified
were
examined
through
interaction
AD-MSCs.
Calcium
histochemical
analysis
performed
investigate
synergistic
effect
LF-PEMF.
It
determined
that
application
(50
µg/mL)
(1.3
mT,
15
Hz)
did
not
demonstrate
cytotoxic
on
modification
ensured
homogeneous
distribution
within
cells,
cationic
being
predominantly
localized
around
nucleus,
while
anionic
dispersed
cytoplasm.
Furthermore,
exposure
influenced
cell
morphology,
leading
increased
cytoplasmic
extensions,
particularly
interacting
silica-coated
MNPs.
These
results
shed
light
importance
stimulation
pave
way
future
studies.
Graphical
abstract
Langmuir,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 10, 2025
Understanding
and
controlling
the
surface
properties
of
bioscaffolds
are
crucial
for
regulating
cell
adhesion
proliferation
behaviors.
We
here
focused
on
poly(vinylidene
fluoride)
(PVDF),
in
which
polymer
chains
oriented
through
poling
treatment
to
form
a
polar
β-form
crystal.
The
aggregation
states
uniaxially
stretched
PVDF
films
subjected
were
investigated
based
water
contact
angle
measurements
sum-frequency
generation
spectroscopy.
During
under
sufficiently
strong
electric
field,
dipole
moments
crystals,
inherently
aligned
within
each
crystalline
domain,
become
more
uniformly
across
entire
film.
As
result,
resists
structural
reorganization
even
upon
exposure
water.
This
stable
surface,
maintains
its
despite
environmental
changes,
was
found
promote
proliferation,
as
well
protein
adsorption.
Our
findings
contribute
deeper
understanding
relationship
between
scaffold
surfaces
interactions,
ultimately
advancing
insights
into
