Mechanisms of drug resistance in nutrient-depleted colorectal cancer cells: insights into lysosomal and mitochondrial drug sequestration DOI Creative Commons
Shingo Kose, Aliye Ezgi Güleç Taşkıran

Biology Open, Journal Year: 2024, Volume and Issue: 13(10)

Published: July 15, 2024

ABSTRACT This Review delves into the mechanisms behind drug resistance in colorectal cancer (CRC), particularly examining role of nutrient depletion and its contribution to multidrug (MDR). The study highlights metabolic adaptations cells as well under low availability, including shifts glycolysis lipid metabolism. It emphasizes significance MDR1 encoded efflux transporter, P-glycoprotein (P-gp/B1), mediating how pathways such HIF1α, AKT, mTOR influence expression P-gp/B1 limited availability. Additionally, explores dual roles autophagy sensitivity conditions. further investigates involvement lysosomes mitochondria, focusing on their sequestration challenges posed by lysosomal entrapment facilitated non-enzymatic processes ABC transporters like P-gp/B1. Finally, underscores importance understanding interplay between sequestration, functions, depletion, gene modulation. suggests innovative strategies, structural modifications nanotechnology, promising approaches overcoming therapy.

Language: Английский

High expression of GPR176 predicts poor prognosis of gastric cancer patients and promotes the proliferation, migration, and invasion of gastric cancer cells DOI Creative Commons
Yu Zhang, Xinliang Gu, Feilong Zhu

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: June 8, 2023

Abstract G-protein-coupled receptors (GPCRs) are the most prominent family of cell surface receptors, which can regulate various biological functions and play an essential role in many diseases. GPR176 is a member GPCRs has been rarely studied cancer. We aim to investigate diagnostic prognostic value gastric cancer (GC) explore its potential mechanism. Through TCGA database real-time quantitative PCR, we found that expression level was significantly increased GC had good diagnosis prognosis GC. Vitro experiments revealed could promote proliferation, migration, invasion cells may be involved regulating multiple tumors immune-related signaling pathways. In addition, associated with immune infiltration affect efficacy patients. summary, high poor prognosis, more robust infiltration, worse immunotherapy patients, suggesting biomarker for cells.

Language: Английский

Citations

3
Identifying key genes related to the peritubular capillary rarefaction in renal interstitial fibrosis by bioinformatics DOI Creative Commons
Yu Zhang, Chuanbing Shi,

Yiqiong Yang

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Nov. 10, 2023

Renal interstitial fibrosis (RIF) is a key feature of progressive chronic kidney disease (CKD), characterized by tubular epithelial cell (TEC) hypoxia and peritubular capillary (PTC) rarefaction. However, the mechanisms underlying these processes remain poorly understood. To address this knowledge gap, we conducted comparative transcriptome analysis hypoxic normoxic HK-2 cells, identifying 572 differentially expressed genes (DEGs). Subsequent Gene Ontology (GO), protein‒protein interaction (PPI) network, hub gene analyses revealed significant enrichment DEGs in HIF-1 signaling pathway based on KEGG analysis. further explore TEC modulation under conditions, performed chromatin immunoprecipitation (ChIP) sequencing targeting HIF-1α, 2915 potentially regulated HIF-1α. By comparing RNA ChIP data, identified 43 overlapping DEGs. performing GO peak annotation with IGV, two candidate molecules, VEGFA BTG1, that are associated angiogenesis whose sequences were reliably bound Our study elucidates molecular RIF, providing valuable insights for potential therapeutic interventions.

Language: Английский

Citations

3
Network pharmacology-based analysis on the key mechanisms of Yiguanjian acting on chronic hepatitis DOI Creative Commons
Xiaodan Jiang, Xinyi Cui, Ruifang Nie

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(9), P. e29977 - e29977

Published: May 1, 2024

Language: Английский

Citations

0
From macroautophagy to mitophagy: Unveiling the hidden role of mitophagy in gastrointestinal disorders DOI Creative Commons

Duo-Lun Gao,

Meng-Ran Lin,

Nan Ge

et al.

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(23), P. 2934 - 2946

Published: June 20, 2024

In this editorial, we comment on an article titled "Morphological and biochemical characteristics associated with autophagy in gastrointestinal diseases", which was published a recent issue of the

Language: Английский

Citations

0
Mechanisms of drug resistance in nutrient-depleted colorectal cancer cells: insights into lysosomal and mitochondrial drug sequestration DOI Creative Commons
Shingo Kose, Aliye Ezgi Güleç Taşkıran

Biology Open, Journal Year: 2024, Volume and Issue: 13(10)

Published: July 15, 2024

ABSTRACT This Review delves into the mechanisms behind drug resistance in colorectal cancer (CRC), particularly examining role of nutrient depletion and its contribution to multidrug (MDR). The study highlights metabolic adaptations cells as well under low availability, including shifts glycolysis lipid metabolism. It emphasizes significance MDR1 encoded efflux transporter, P-glycoprotein (P-gp/B1), mediating how pathways such HIF1α, AKT, mTOR influence expression P-gp/B1 limited availability. Additionally, explores dual roles autophagy sensitivity conditions. further investigates involvement lysosomes mitochondria, focusing on their sequestration challenges posed by lysosomal entrapment facilitated non-enzymatic processes ABC transporters like P-gp/B1. Finally, underscores importance understanding interplay between sequestration, functions, depletion, gene modulation. suggests innovative strategies, structural modifications nanotechnology, promising approaches overcoming therapy.

Language: Английский

Citations

0