Calcium phosphate-based anti-infective bone cements: recent trends and future perspectives

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 26, 2025

Bone infection remains a challenging condition to fully eradicate due its intricate nature. Traditional treatment strategies, involving long-term and high-dose systemic antibiotic administration, often encounter difficulties in achieving therapeutic drug concentrations locally may lead resistance. cement, serving as local delivery matrix, has emerged an effective anti-infective approach validated clinical settings. Calcium phosphate cements (CPCs) have garnered widespread attention application the management of bone infections their injectable properties, biocompatibility, degradability. The interconnected porous structure calcium particles, not only promotes osteoconductivity osteoinductivity, but also serves ideal carrier for antibacterial agents. Various antimicrobial agents, including polymeric compounds, antibiotics, peptides, inorganic ions (TIIs) (and nanoparticles), graphene, iodine, been integrated into CPC matrices numerous studies aimed at treating diverse applications such defect filling, preparation metal implant surface coatings, coating surfaces. Additionally, defects nonunions resulting from chronic infections, utilization phosphate-calcium sulfate composite multifunctional cement loaded with agents efficiently deal infection, stimulate new formation, attain optimal degradation rate matrix. This review briefly delves various strategies based on prevention while discussing composites development against infections.

Language: Английский

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A nanocatalytic membrane with sono-responsive antibacterial therapy (SRAT) for rapid sterilization and enhanced chronic wound healing

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A novel PN-bioHJ membrane combining black phosphorus and barium titanate on a PLGA platform achieves >99% antibacterial efficiency under ultrasound, with excellent biocompatibility for infected tissue regeneration.

Language: Английский

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Optimizing lipase production by Bacillus subtilis on cheese whey and evaluating its antimicrobial, antibiofilm, anti virulence and biosafety properties

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 1, 2025

Abstract This study optimized lipase production using cheese whey, biofilm inhibition, and antibacterial efficacy of Bacillus subtilis (DSM 1088)derived against Staphylococcus aureus (ATCC 6538). Peak activity, growth rate, inhibitory potential were observed at 48 h 30 °C. Using Plackett-Burman Central Composite Designs (PBD CCD), peptone, agitation speed identified as significant factors, achieving optimal activity 1314 U/mL an zone diameter (IZD) mm S. . Partial purification through ammonium sulfate precipitation dialysis increased partial purified (PPL) by twofold fivefold, respectively. PPL exhibited effective bactericidal properties with a minimum concentration (MIC) minimal (MBC) 1/8 1/16, confirming effect (MIC/MBC ratio ≤ 2). Biofilm inhibition assays demonstrated 95% reduction 80 µg/mL PPL, SEM imaging revealing matrix disruption. Time-kill showed concentration-dependent action, while hemolysin protease activities (25–100%) indicated reduced pathogenicity. Cytotoxicity on normal liver cells IC50 > 300 µg/mL, indicating low toxicity. GC/MS analysis oil waste before degradation predominantly oleic acid 3-hydroxypropyl ester octadecane derivatives, after degradation, it revealed enriched free fatty acids including myristic, palmitic, linoleic, acids, which could enhance antimicrobial efficacy. Molecular docking suggested that inhibits essential bacterial enzymes (folic synthetase, RNA polymerase, DNA gyrase), potentially disrupting synthesis promoting cell death. These findings highlight B. -derived promising bio-agent for combating biofilm-associated, drug-resistant pathogens clinical industrial applications.

Language: Английский

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Bacterial Capture‐Killing Capsules with Remodeling Bone Immune Microenvironment for the Effective Treatment of Osteomyelitis

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Osteomyelitis represents a significant health concern, characterized by bacterial infection that can potentially present considerable challenge to clinical treatment. Current treatment strategies, including prolonged antibiotic regimens and surgical debridement, often fail adequately resolve or support bone regeneration, largely due the pathogen‐induced dysregulation of microenvironment. This study reports multifunctional capsule achieves coordinated capture‐killing immunomodulatory within osseous tissue, effectively resolving dual pathological challenges persistent microenvironment dysregulated regeneration inherent osteomyelitis. The capsules, PC‐O@TOB, are based on Schiff base reaction procyanidins (PC) with amino Lysine6‐osteogenic growth peptide (K6‐OGP) tobramycin (TOB), which allows for efficient loading controllable release K6‐OGP TOB. In vitro in vivo studies demonstrated PC‐O@TOB exhibits functionality: potent bactericidal activity through capture localized delivery, microenvironmental remodeling via ROS scavenging M2 macrophage polarization. effect synergizes capsule's osteogenic angiogenic properties accelerate repair. strategy antibacterial later has opened up new way

Language: Английский

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A three-in-one nanoplatform with photo/chemodynamic activities combined with glutathione depletion for treating bacterial infections

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 651, P. 448 - 463

Published: July 27, 2023

Language: Английский

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