Public Health, Journal Year: 2024, Volume and Issue: 238, P. 245 - 253
Published: Dec. 18, 2024
Language: Английский
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: March 7, 2024
Abstract Sexual dimorphism has been observed in the incidence and prognosis of colorectal cancer (CRC), with men generally exhibiting a slightly higher than women. Research suggests that this difference may be attributed to variations sex steroid hormone levels gut microbiome. The microbiome CRC shows composition function between sexes, leading concept ‘microgenderome’ ‘sex hormone–gut axis.’ Conventional research indicates estrogens, by promoting more favorable microbiota, reduce risk CRC. Conversely, androgens have direct pro-tumorigenic effect increasing proportion opportunistic pathogens. microbiota also influence expressing specific enzymes or directly affecting gonadal function. However, area remains controversial. This review aims explore differences incidence, phenomenon sexual within microbiome, intricate interplay axis objective is gain better understanding these interactions their potential clinical implications, as well introduce innovative approaches treatment. Graphical
Language: Английский
Citations
19
Advanced Science, Journal Year: 2023, Volume and Issue: 10(25)
Published: July 3, 2023
Abstract Men demonstrate higher incidence and mortality rates of colorectal cancer (CRC) than women. This study aims to explain the potential causes such sexual dimorphism in CRC from perspective sex‐biased gut microbiota metabolites. The results show that tumorigenesis is observed both Apc Min/ + mice azoxymethane (AOM)/dextran sulfate sodium (DSS)‐treated with male have significantly larger more tumors, accompanied by impaired barrier function. Moreover, pseudo‐germ receiving fecal samples or patients severe intestinal damage level inflammation. A significant change composition found increased pathogenic bacteria Akkermansia muciniphila deplets probiotic Parabacteroides goldsteinii sample mice. Sex‐biased metabolites contribute sex through glycerophospholipids metabolism pathway. Sexual mouse models. In conclusion, microbiome CRC. Modulating could be a sex‐targeting therapeutic strategy
Language: Английский
Citations
23
Cell Reports, Journal Year: 2024, Volume and Issue: 43(1), P. 113654 - 113654
Published: Jan. 1, 2024
Deficiency of DNA repair pathways drives the development colorectal cancer. However, role base excision (BER) pathway in cancer initiation remains unclear. This study shows that Nei-like glycosylase 1 (NEIL1) is highly expressed (CRC) tissues and associated with poorer clinical outcomes. Knocking out neil1 mice markedly suppresses tumorigenesis enhances infiltration CD8+ T cells intestinal tumors. Furthermore, NEIL1 directly forms a complex SATB2/c-Myc to enhance transcription COL17A1 subsequently promotes production immunosuppressive cytokines CRC cells. A peptide ApcMin/+ mice, targeting demonstrates synergistic suppressive effect on tumor growth when combined nuclear factor κB (NF-κB) inhibitor. These results suggest NF-κB may represent promising strategy for therapy.
Language: Английский
Citations
13
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14
Published: Jan. 16, 2025
Colorectal cancer (CRC) is a common malignancy with notable recent shifts in its burden distribution. Current data on CRC can guide screening, early detection, and treatment strategies for efficient resource allocation. This study utilized from the latest Global Burden of Diseases, Injuries, Risk Factors (GBD) Study. Initially, series descriptive statistics were performed incident cases, deaths, disability-adjusted life years (DALYs), age-standardized rates (ASRs) CRC. Percentage changes average annual percentage (AAPC) then calculated to understand trends disease burden. Decomposition frontier analyses conducted, finally, Bayesian age-period-cohort (BAPC) model was used predict ASRs up 2040. The GBD 2021 estimates indicate significant increase global DALYs 1990 2021. incidence rate (ASIR) increased (AAPC: 0.2), while mortality (ASMR) -0.72) -0.73) decreased. Males bore higher than females, though similar both sexes. Although developed regions had DALYs, they showed more declines ASRs. analysis revealed that population growth aging primary drivers Frontier as Socio-demographic Index increased, disparity among countries widened, having greater potential reduce these rates. By 2040, BAPC projects ASMR rates, ASIR expected decrease females but males across remains public health issue regional gender differences, necessitating region- population-specific prevention strategies.
Language: Английский
Citations
1
Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102666 - 102666
Published: Jan. 1, 2025
Language: Английский
Citations
1
Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13
Published: Dec. 12, 2023
Colorectal cancer (CRC) is a common malignancy of the gastrointestinal tract, accounting for second most cause tumors. As one intestinal barriers, gut bacteria form biofilm, participate in work, and living environment cells. Metagenomic next-generation sequencing (mNGS) large number CRC patients has been established, enabling specific microbial signatures to be associated with colorectal adenomato-carcinoma. Gut are involved both benign precursor lesions (polyps), situ growth metastasis CRC. Therefore, term tumorigenic was proposed 2018, such as Escherichia coli , Fusobacterium nucleatum enterotoxigenic Bacteroides fragilis etc. Meanwhile, toxins (such cytolethal distending toxin (CDT), Colibactin (Clb), B. toxin) affect tumor microenvironment promote occurrence immune escape. It important note that there differences different types In this paper, role polyp-cancer transformation effects their secreted on will discussed, thereby further exploring new ideas prevention treatment
Language: Английский
Citations
12
Indus journal of bioscience research., Journal Year: 2025, Volume and Issue: 3(1), P. 245 - 254
Published: Jan. 16, 2025
Maintaining balanced microflora in animals is essential for health, immunity, and productivity, particularly considering the increasing global demand antibiotic-free animal products. This review examines contributions of prebiotics probiotics, separately combination as synbiotics, to gastrointestinal health enhancement performance. consolidates contemporary data regarding these therapies' mechanisms, uses, advantages, highlighting their capacity foster microbial stability, improve nutrient absorption, augment immunological responses across diverse species, including poultry, swine, ruminants, aquaculture. Key themes, effectiveness prebiotic probiotic strains, discrepancies literature concerning doses, combinations, species-specific treatments are examined. The additionally analyzes synergistic effects which enhance advantages chemicals. current research landscape, identifies significant knowledge gaps, provides insights into difficulties potential enhancing microbial-based techniques production systems. results underscore promise probiotics sustainable substitutes antibiotics, welfare while mitigating environmental livestock culminates with recommendations future research, necessity longitudinal investigations, established methodology, investigation innovative microbiological possibilities. It enhances comprehension implementation therapies, providing a basis superior management practices agriculture.
Language: Английский
Citations
0
European Journal of Cancer Prevention, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 18, 2025
Background Colorectal cancer (CRC) poses a significant health burden in Europe, but comprehensive studies on this region are limited. Methods Using data from the Global Burden of Diseases (GBD), Injuries, and Risk Factors Study 2021, we analyzed regional distribution temporal trends CRC early-onset Europe 1990 to 2021. Decomposition analysis was applied quantify contributions population growth, aging, epidemiological changes. The research also evaluated major risk factors associated with CRC. Results found be higher than global average. While age-standardized incidence rate (ASIR) increased, both mortality (ASMR) disability-adjusted life years (ASDR) decreased. Early-onset exhibits similar characteristics patterns change. Males had significantly females. Population aging primary driver increased Europe. factor revealed that low whole grain intake high red meat consumption were contributors elevated ASMR ASDR Additionally, BMI fasting plasma glucose showed an increasing trend. Conclusion overall remains level, ASIR decreasing ASDR. Targeted prevention control strategies should developed based for Older adults men prioritized interventions.
Language: Английский
Citations
0
iMeta, Journal Year: 2024, Volume and Issue: 3(6)
Published: Nov. 6, 2024
First introduced in 2021, MetOrigin has quickly established itself as a powerful web server to distinguish microbial metabolites and identify the bacteria responsible for specific metabolic processes. Building on growing understanding of interplay between microbiome metabolome, response user feedback, undergone significant upgrade version 2.0. This enhanced incorporates three new modules: (1) Quick search module that facilitates rapid identification associated with particular metabolite; (2) Orthology analysis links enzyme genes their corresponding bacteria; (3) Mediation investigates potential causal relationships among bacteria, metabolites, phenotypes, highlighting mediating role metabolites. Additionally, backend database been updated latest data from seven public databases (KEGG, HMDB, BIGG, ChEBI, FoodDB, Drugbank, T3DB), expanded coverage 210,732 each linked its source organism. 2.0 is freely accessible at http://metorigin.met-bioinformatics.cn.
Language: Английский
Citations
3
iMetaOmics., Journal Year: 2025, Volume and Issue: unknown
Published: March 18, 2025
Abstract Inflammatory bowel disease (IBD) is a chronic disorder linked to an increased risk of colorectal cancer (CRC) and characterized by significant dysbiosis in the gut microbiota. The commensal bacterium Parabacteroides goldsteinii ( P. ) has shown potential modulating host metabolism inflammatory responses. In this study, we investigated probiotic properties its mechanism action IBD models, with particular focus on bile acid diet‐microbiota interactions. Fecal samples from patients ulcerative colitis n = 14), Crohn's 22), healthy controls 13) were analyzed assess relative abundance. dextran sulfate sodium (DSS)‐induced azoxymethane (AOM)/DSS‐induced CRC mouse administration significantly attenuated inflammation tumorigenesis, particularly under fiber‐free diet conditions. Metabolomic profiling revealed enrichment secondary acids ‐treated mice, suggesting link between anti‐inflammatory effects. Further mechanistic studies using salt hydrolase inhibitors Tgr5 knockout mice confirmed role regulation mediating therapeutic benefits . Additionally, found that dietary factors influenced colonization metabolic activity , thereby efficacy. This highlights for microbiome‐based therapies tailored specific contexts treatment IBD. Our findings demonstrate can modulate alleviate colitis, making it promising candidate applications management, modulation enhancing potential.
Language: Английский
Citations
0