Global, regional, and national burden of early-onset colorectal cancer and projection to 2050: An analysis based on the Global Burden of Disease Study 2021 DOI
Xinyi Li,

Xueyan Xiao,

Zenghong Wu

et al.

Public Health, Journal Year: 2024, Volume and Issue: 238, P. 245 - 253

Published: Dec. 18, 2024

Language: Английский

Early versus Late Onset Colorectal Cancer: Pathological Distinctions and Optimal Screening Age Determination in a Decade-Long Study DOI Creative Commons

Jiawei Song,

Tenghui Han,

Qian Lei

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 4, 2024

Abstract Background and Aim: The incidence of Early-Onset Colorectal Cancer (EOCRC) is increasing. However, the prognosis EOCRC compared to Late-Onset (LOCRC), ideal age for initial colorectal cancer (CRC) screening are not clear. In this study, we identified pathological differences between groups determined optimal CRC patients. Methods: We included 10,172 patients diagnosed with from January 2011 December 2021 in study. Survival were by plotting Kaplan-Meier survival curves conducting landmark analysis. Additionally, diagnostic was analyzed using cumulative curves. Results: Compared LOCRC patients, had a higher proportion defective mismatch repair (dMMR) more advanced TNM staging (P < 0.05). The five-year significantly better than that Laparoscopic surgery improved long-term Proficient (pMMR) favored rate at stages I II same curve showed substantial increase number 40 years. Conclusion: especially among those pMMR, I-II, who undergo laparoscopic surgery. For high-risk groups, starting should be

Language: Английский

Citations

0
Apple polysaccharide improves age-matched cognitive impairment and intestinal aging through microbiota-gut-brain axis DOI Creative Commons
Wenming Zhang,

Yuchun Zhong,

Zhuoya Wang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 13, 2024

Abstract The Apple polysaccharides (AP), extracted from the fruit of apple, has been used to treat multiple pathological diseases. In this study, we evaluated effects AP on cognitive impairment and intestinal aging in naturally mice. As a result, it was found that could improve spatial learning memory mice through Morris water maze experiment. Additionally, intervention can upregulate expression nerve growth factor (BDNF), postsynaptic marker (PSD95), presynaptic (SYP) proteins. Moreover, enhance total antioxidant capacity, reduce level pro-inflammatory cytokine, inhibit activation NF-κB signaling pathway, exerting anti-inflammatory functions. And administration restored mucosal barrier function, reduced apoptosis related also altered gut microbiota At genus level, decreased abundance Helicobacter Bilophila , while increased Lactobacillus Bacteroides . summary, these data demonstrate treatment alleviate impairment, oxidative stress, inflammatory reactions, repair barrier, aging, alter specific microbial characteristics, ultimately improving health elderly.

Language: Английский

Citations

0
结直肠癌肠道微生物群的性二态性 DOI

Zihong Wu,

Ziming Wang,

Jiamei Wang

et al.

Chinese Science Bulletin (Chinese Version), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Citations

0
Global, regional, and national burden of early-onset colorectal cancer and projection to 2050: An analysis based on the Global Burden of Disease Study 2021 DOI
Xinyi Li,

Xueyan Xiao,

Zenghong Wu

et al.

Public Health, Journal Year: 2024, Volume and Issue: 238, P. 245 - 253

Published: Dec. 18, 2024

Language: Английский

Citations

0