Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(28)
Published: May 20, 2024
Abstract
The
hyperglycemic
pathophysiological
environment
in
diabetic
wounds
is
a
major
obstacle
that
impedes
the
healing
process.
Glucose‐responsive
wound
materials
are
promising
approach
to
address
this
challenge.
In
study,
complex
coacervate‐based
protocells
introduced
for
healing.
By
employing
microfluidic
chip
with
an
external
mechanical
vibrator,
uniform
coacervate
microdroplets
generated
via
electrostatic
interactions
between
diethylaminoethyl‐dextran
and
double‐stranded
DNA.
spontaneous
assembly
of
phospholipid
membrane
on
droplet
surface
enhances
its
biocompatibility.
Glucose
oxidase
copper
peroxide
nanodots
integrated
into
microdroplets,
enabling
glucose‐responsive
cascade
produces
hydroxyl
radicals
as
antibacterial
agents.
These
features
contribute
efficient
activity
mice.
present
facilitate
intelligent
management,
design
catalytic
coacervates
can
development
various
smart
vehicles
drug
delivery.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(10), P. 11037 - 11052
Published: May 15, 2024
Diabetic
wound
infection
has
always
been
a
huge
threat
to
human's
healthcare,
and
most
of
the
existing
therapies
have
reduced
efficacy,
drug
resistance
toxic
side
effects.
Therefore,
there
is
an
urgent
need
develop
innovative
therapeutic
strategies
for
diabetic
management.
At
present,
intelligence
stimulus-responsive
bioactive
hydrogels
in
healing
received
extensive
attention.
This
mainly
reflected
on-demand
release
active
substances
response
physical,
chemical
or
biological
stimuli.
paper
focuses
on
potential
various
their
applications
healing,
briefly
discusses
factors
slow
preparation
methods
smart
hydrogels.
Finally,
future
development
further
management
wounds
presented.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(28)
Published: May 20, 2024
Abstract
The
hyperglycemic
pathophysiological
environment
in
diabetic
wounds
is
a
major
obstacle
that
impedes
the
healing
process.
Glucose‐responsive
wound
materials
are
promising
approach
to
address
this
challenge.
In
study,
complex
coacervate‐based
protocells
introduced
for
healing.
By
employing
microfluidic
chip
with
an
external
mechanical
vibrator,
uniform
coacervate
microdroplets
generated
via
electrostatic
interactions
between
diethylaminoethyl‐dextran
and
double‐stranded
DNA.
spontaneous
assembly
of
phospholipid
membrane
on
droplet
surface
enhances
its
biocompatibility.
Glucose
oxidase
copper
peroxide
nanodots
integrated
into
microdroplets,
enabling
glucose‐responsive
cascade
produces
hydroxyl
radicals
as
antibacterial
agents.
These
features
contribute
efficient
activity
mice.
present
facilitate
intelligent
management,
design
catalytic
coacervates
can
development
various
smart
vehicles
drug
delivery.
