Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 376, P. 794 - 805
Published: Nov. 1, 2024
Language: Английский
Drug Resistance Updates, Journal Year: 2024, Volume and Issue: 78, P. 101170 - 101170
Published: Nov. 15, 2024
Language: Английский
Citations
18
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: Nov. 21, 2024
Metabolic alterations, a hallmark of cancer, enable tumor cells to adapt their environment by modulating glucose, lipid, and amino acid metabolism, which fuels rapid growth contributes treatment resistance. In primary breast metabolic shifts such as the Warburg effect enhanced lipid synthesis are closely linked chemotherapy failure. Similarly, metastatic lesions often display distinct profiles that not only sustain but also confer resistance targeted therapies immunotherapies. The review emphasizes two major aspects: mechanisms driving in both how unique environments sites further complicate treatment. By targeting vulnerabilities at stages, new strategies could improve efficacy existing provide better outcomes for cancer patients.
Language: Английский
Citations
17
Advanced Science, Journal Year: 2023, Volume and Issue: 10(17)
Published: April 25, 2023
Abstract In this study, it is found that the lncRNA, DNA damage inducible transcript 4 antisense RNA1 (DDIT4‐AS1), highly expressed in triple‐negative breast cancer (TNBC) cell lines and tissues due to H3K27 acetylation promoter region, promotes proliferation, migration, invasion of TNBC cells via activating autophagy. Mechanistically, shown DDIT4‐AS1 induces autophagy by stabilizing DDIT4 mRNA recruiting RNA binding protein AUF1 promoting interaction between AUF1, thereby inhibiting mTOR signaling pathway. Furthermore, silencing enhances sensitivity chemotherapeutic agents such as paclitaxel both vitro vivo. Using a self‐activatable siRNA/drug core–shell nanoparticle system, which effectively deliver siRNA tumor‐bearing mice, significantly enhanced antitumor activity achieved. Importantly, codelivery nanoparticles exert stronger effect on patient‐derived organoids. These findings indicate lncRNA DDIT4‐AS1‐mediated activation progression chemoresistance TNBC, targeting may be exploited new therapeutic approach enhancing efficacy chemotherapy against TNBC.
Language: Английский
Citations
40
Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)
Published: July 5, 2024
Abstract Chemotherapy is currently one of the most effective methods in clinical cancer treatment. However, chemotherapy resistance an important reason for poor efficacy and prognosis, which has become urgent problem to be solved field chemotherapy. Therefore, it very deeply study analyze mechanism its regulatory factors. Long non-coding RNA nuclear paraspeckle assembly transcript 1 (LncRNA NEAT1) been shown closely associated with cancer. NEAT1 induces cell chemotherapeutic drugs by regulating apoptosis, cycle, drug transport metabolism, DNA damage repair, EMT, autophagy, stem characteristics, metabolic reprogramming. This indicates that may target overcome expected a potential biomarker predict effect article summarizes expression characteristics different cancers, discusses role related molecular mechanisms, aiming clarify as new feasibility sensitizers, view providing therapeutic direction overcoming dilemma future.
Language: Английский
Citations
10
Experimental Cell Research, Journal Year: 2025, Volume and Issue: unknown, P. 114531 - 114531
Published: March 1, 2025
Language: Английский
Citations
1
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(6), P. 2447 - 2474
Published: March 18, 2024
The clinical efficacy of current cancer therapies falls short, and there is a pressing demand to integrate new targets with conventional therapies. Autophagy, highly conserved self-degradation process, has received considerable attention as an emerging therapeutic target for cancer. With the rapid development nanomedicine, nanomaterials have been widely utilized in therapy due their unrivaled delivery performance. Hence, considering potential benefits integrating autophagy nanotechnology therapy, we outline latest advances autophagy-based nanotherapeutics. Based on brief background related nanotherapeutics impact tumor progression, feasibility treatment demonstrated. Further, developed modulate are reviewed from perspective cell signaling pathways, including modulation mammalian rapamycin (mTOR) pathway, autophagy-related (ATG) its complex expression, reactive oxygen species (ROS) mitophagy, interference autophagosome-lysosome fusion, inhibition hypoxia-mediated autophagy. In addition, combination which nano-autophagy combined chemotherapy, phototherapy, immunotherapy also described. Finally, prospects challenges efficient envisioned.
Language: Английский
Citations
8
Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: June 12, 2024
Long non-coding RNAs (lncRNAs) are a sort of transcripts that more than 200 nucleotides in length. In recent years, many studies have revealed the modulatory role lncRNAs cancer. Typically, linked to variety essential events, such as apoptosis, cellular proliferation, and invasion malignant cells. Simultaneously, autophagy, an intracellular degradation mechanism eukaryotic cells, is activated respond multiple stressful circumstances, for example, nutrient scarcity, accumulation abnormal proteins, organelle damage. Autophagy plays both suppressive promoting roles Increasingly, unveiled how dysregulated expression can disrupt autophagic balance, thereby contributing cancer progression. Consequently, exploring interplay between autophagy holds promising implications clinical research. this manuscript, we methodically compiled advances molecular mechanisms briefly summarized lncRNA-mediated axis.
Language: Английский
Citations
6
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(12), P. 5106 - 5131
Published: Nov. 2, 2024
Reactive oxygen species (ROS)-responsive drug delivery systems (DDSs) have garnered significant attention in cancer research because of their potential for precise spatiotemporal release tailored to high ROS levels within tumors. Despite the challenges posed by distribution heterogeneity and endogenous supply constraints, this review highlights strategic alliance ROS-responsive DDSs with photodynamic therapy (PDT), enabling selective leveraging PDT-induced enhanced therapeutic efficacy. This delves into biological importance progression treatment. We elucidate detail operational mechanisms linkers, including thioether, thioketal, selenide, diselencide, telluride aryl boronic acids/esters, as well latest developments nanomedicines that integrate PDT strategies. These insights are intended inspire design innovative nanocarriers PDT.
Language: Английский
Citations
6
Journal of Experimental & Clinical Cancer Research, Journal Year: 2024, Volume and Issue: 43(1)
Published: June 26, 2024
Abstract Background Paclitaxel (PTX) treatment resistance is an important factor leading to poor prognosis in triple-negative breast cancer (TNBC), therefore there urgent need identify new target for combination therapy. Neddylation a post-translational process that introduces ubiquitin-like protein called neural precursor cell expressed developmentally downregulated 8 (NEDD8). Previous studies have found neddylation activated multiple tumors, but its relationship with PTX chemotherapy sensitivity has not been reported. Methods Differences UBC12 and NEDD8 expression levels between PTX-sensitive PTX-insensitive TNBC tissues were validated using public databases immunohistochemistry. The vitro vivo functional experiments used observe the effect of inhibition combined therapy on tumor progression. Co-IP, western blot PCR assays investigate molecular mechanisms. Molecular docking was simulate binding TRIM25. dynamics simulation changes TRIM25 conformation. Results We insensitive PTX, conjugating enzyme are highly expressed. Treatment NEDD8-activating (NAE) inhibitor mln4924 or knockdown significantly increased this increase related UBC12-mediated autophagy activation. Mechanistically, can transfer E3 ubiquitin ligase tripartite motif containing 25 (TRIM25) at K117. simulations indicate modification reduces steric hindrance RING domain, facilitating ubiquitylated substrates. Subsequently, promotes nuclear translocation transcription EB (TFEB) genes by increasing K63-polyubiquitination TFEB, thereby reducing PTX. Conclusions TNBC. Specifically, gene transcriptional activation mediated UBC12/TRIM25/TFEB axis suppression shows synergistic anti-tumor effect.
Language: Английский
Citations
5
ACS Nano, Journal Year: 2024, Volume and Issue: 18(28), P. 18282 - 18298
Published: July 2, 2024
The therapeutic efficacy of oncolytic adenoviruses (OAs) relies on efficient viral transduction and replication. However, the limited expression coxsackie-adenovirus receptors in many tumors, along with intracellular antiviral signaling, poses significant obstacles to OA infection oncolysis. Here, we present sonosensitizer-armed OAs (saOAs) that potentiate antitumor virotherapy through sonodynamic therapy-augmented virus saOAs could not only efficiently infect tumor cells via transferrin receptor-mediated endocytosis but also exhibit enhanced replication oncolysis under ultrasound irradiation. We revealed sonosensitizer loaded viruses induced generation ROS within cells, which triggered JNK-mediated autophagy, ultimately leading In mouse models malignant melanoma, combination therapy elicited a robust immune response, resulting inhibition melanoma growth improved host survival. This work highlights potential enhancing effectiveness provides promising platform for fully exploiting virotherapy.
Language: Английский
Citations
5